The pathogenic role of immunoglobulin A polymers in immunoglobulin A nephropathy.

abstract：:Tubular necrosis elicits a process of renal tissue repair characterized by an increase of cell turnover in tubular epithelium. The present study was undertaken to examine the distribution of epidermal growth factor (EGF) and/or of its larger precursor proEGF in the kidney undergoing tubular regeneration. Sprague-Dawle...

journal_title：Nephron

authors： Nonclercq D,Toubeau G,Lambricht P,Heuson-Stiennon JA,Laurent G

更新日期：1991-01-01 00:00:00

abstract：:A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...

journal_title：Nephron

authors： Lin CH,Huang JJ,Liu HL,Lee SY,Hsieh RY,Tseng CC

更新日期：2002-09-01 00:00:00

abstract：:The accumulation in blood plasma and efficiency of hemodialysis of pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronic renal failure (CRF) was investigated. As a reference, the analysis of the above metabolites in the plasma of ...

journal_title：Nephron

authors： Daniewska-Michalska D,Motyl T,Gellert R,Kukulska W,Podgurniak M,Opechowska-Pacocha E,Ostrowski K

更新日期：1993-01-01 00:00:00

abstract：:We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. Th...

journal_title：Nephron

authors： Hashim OH,Shuib AS,Chua CT

更新日期：2001-12-01 00:00:00

abstract：:In order to assess the effects of sodium depletion on tubular Na and H2O transport in man, renal clearance studies were performed under control conditions and after sodium depletion in 7 normal subjects. The control diet contained 250 mEq of Na daily. Sodium depletion was induced by placing subjects on a 20-mEq/day na...

journal_title：Nephron

authors： DiScala VA,Stein RM

更新日期：1982-01-01 00:00:00

abstract：:To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in pla...

journal_title：Nephron

authors： Niwa T,Fujishiro T,Uema K,Tsuzuki T,Tominaga Y,Emoto Y,Miyazaki T,Maeda K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a cytokine which plays an important role in the division, proliferation and migration of endothelial cells. In the kidney, VEGF expression is found in glomerular podocytes and in tubular epithelial cells, which may result in acute inflammatory reactions. METHODS:...

journal_title：Nephron

authors： Prakash S,Agrawal S,Kumar S,Prasad N

更新日期：2015-01-01 00:00:00

abstract：:A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...

journal_title：Nephron

authors： Tweeddale MG,Fodor JG

更新日期：1979-01-01 00:00:00

abstract：:A 45-year-old male was admitted to the hospital because of polyuria and polydipsia. After admission, proteinuria and hematuria were found. The kidney function deteriorated and necessitated the initiation of chronic hemodialysis. Examination of the bone marrow revealed multiple myeloma and kappa light chains were found...

journal_title：Nephron

authors： Knobler H,Kopolovic J,Kleinman Y,Rubinger D,Silver J,Friedlaender MM,Popovtzer MM

更新日期：1983-01-01 00:00:00

abstract：:Experiments were conducted which revealed the renal transport mechanism(s) of oxypurines by employing uricosuric agents and pyrazinamide. All specimens being drawn from healthy, normal subjects, the data showed that probenecid increased fractional uric acid, fractional hypoxanthine and fractional xanthine clearance, 3...

journal_title：Nephron

authors： Yamamoto T,Moriwaki Y,Takahashi S,Hada T,Higashino K

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Several studies have provided convincing evidence that in apparently healthy subjects elevated serum levels of plasma C-reactive protein (CRP) are associated with an increased risk of experiencing myocardial infarction and sudden cardiac death. It has been claimed that, in dialytic patients, the hepatic synt...

journal_title：Nephron

authors： Panichi V,Migliori M,De Pietro S,Taccola D,Bianchi AM,Giovannini L,Norpoth M,Metelli MR,Cristofani R,Bertelli AA,Sbragia G,Tetta C,Palla R,Colombo R

更新日期：2002-08-01 00:00:00

abstract：:This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...

journal_title：Nephron

authors： Muto S,Asano Y,Hosoda S,Shionoya S,Miura Y,Urabe A,Takaku F

更新日期：1987-01-01 00:00:00

abstract：:The effects of a high-protein (HP) and low-protein (LP) meal on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and renal vascular resistance (RVR) were examined in conscious dogs. Ingestion of the HP and LP meal produced a temporary increase in systemic hemodynamic parameters due in part to a 'c...

journal_title：Nephron

authors： Zawada ET,Saelens DA,Alavi FK,Lembke JM

更新日期：1994-01-01 00:00:00

abstract：:Recent studies have revealed the potential importance of the extracellular matrix (ECM) in the modulation of mesangial cell (MC) function. Interleukin-6 (IL-6) is produced by MCs and was shown to induce MC proliferation, acting as an autocrine growth factor. Heparin is a known inhibitor of MC proliferation. It was sho...

journal_title：Nephron

authors： Benador NM,Girardin EP

更新日期：1997-01-01 00:00:00

abstract：:Copper (Cu) and zinc (Zn) were measured in urine, serum and tissues from rats with nephrotic syndrome (NS) induced with a single subcutaneous dose of puromycin aminonucleoside (PAN; 15 mg/100 g BW). Control animals were pair-fed. Urine was collected daily, and the rats were sacrificed on day 10. PAN-nephrotic rats had...

journal_title：Nephron

authors： Pedraza-Chaverrí J,Torres-Rodríguez GA,Cruz C,Mainero A,Tapia E,Ibarra-Rubio ME,Silencio JL

更新日期：1994-01-01 00:00:00

abstract：:We investigated the incidence of painless (silent) myocardial ischemia, manifested as S-T segment deviation, by Holter ECG monitoring in patients with chronic renal failure undergoing regular hemodialysis. Forty-five patients underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the int...

journal_title：Nephron

authors： Kremastinos D,Paraskevaidis I,Voudiklari S,Apostolou T,Kyriakides Z,Zirogiannis P,Toutouzas P

更新日期：1992-01-01 00:00:00

abstract：:We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreas...

journal_title：Nephron

authors： Maruyama H,Gejyo F,Hanano M,Arakawa M

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Glomerular hyperfiltration (GH) is a hallmark of renal dysfunction in diabetes and obesity. Recent clinical trials demonstrated that SGLT2 inhibitors are renoprotective, possibly by abating hyperfiltration. The present review considers the current evidence for a cause-to-effect relationship between hyperfilt...

journal_title：Nephron

authors： Chagnac A,Zingerman B,Rozen-Zvi B,Herman-Edelstein M

更新日期：2019-01-01 00:00:00

abstract：:A retrospective analysis of renal vein renin results has been done in 96 patients with renal artery stenosis and hypertension studied in two Italian centers (Sassari and Pisa) with respect to the outcome of either surgery or percutaneous transluminal angioplasty (PTA). In all patients the renal vein renin ratio and th...

journal_title：Nephron

authors： Rappelli A,Glorioso N,Madeddu P,Dessì-Fulgheri P,Leoni C,Fiori C,Manca GB,Sanna G,Arzilli F,Pedrinelli R

更新日期：1986-01-01 00:00:00

abstract：:In the present study, activity of polymorphonuclear leukocyte (PMNL) intracellular antioxidant enzymes, i.e. catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), was assessed in CRF patients on hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) and in healthy controls. The activit...

journal_title：Nephron

authors： Shurtz-Swirski R,Mashiach E,Kristal B,Shkolnik T,Shasha SM

更新日期：1995-01-01 00:00:00

abstract：:In 88 patients with the nephrotic syndrome (NS) we estimated plasma volume (PV) with 131I-albumin (RISA) and calculated blood volume (BV) from PV and whole body hematocrit (Ht). To assess whether this method gives erroneously high values in the NS, the transcapillary escape rate of albumin (TER) and large vessel Ht/wh...

journal_title：Nephron

authors： Geers AB,Koomans HA,Boer P,Dorhout Mees EJ

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The herbal medicine Sairei-to is efficacious in renal diseases where mesangial proliferation is a key event. We examined whether Sairei-to inhibits proliferation of cultured rat mesangial cells and investigated its mechanism of action. METHODS:The effect of Sairei-to on [(3)H]-thymidine incorporation stimul...

journal_title：Nephron

authors： Awazu M,Fujita H,Omori S,Hida M

更新日期：2002-01-01 00:00:00

abstract：:Using a 2-hour 47Ca absorption test, significant depression of active calcium absorption was demonstrated in 48 vitamin D untreated haemodialysis patients. This malabsorption of calcium could be corrected by the daily oral administration of 1--2 microgram of 1alphaOHD3 and 1--1.5 microgram of 1,25(OH)2D3. 5 microgram ...

journal_title：Nephron

authors： Pierides AM,Aljama P,Kerr DN,Scott M,Norman AW

更新日期：1978-01-01 00:00:00

abstract：INTRODUCTION:Control of hyperphosphatemia in patients on dialysis remains a major challenge. OBJECTIVE:This study evaluated predictors of serum phosphorus (sP) control among dialysis patients treated with noncalcium, oral phosphate binder therapy in a phase 3 clinical trial. METHODS:Post hoc analyses were performed u...

journal_title：Nephron

authors： Covic AC,Sprague SM,Rastogi A,Ketteler M,Walpen S,Perrin A,Floege J

更新日期：2020-01-01 00:00:00

abstract：:Serum and urinary concentrations of NCl, the non collagenous globular domain of collagen IV, were used as markers for turnover of basement membranes. NCl levels were studied in membranous glomerulonephritis and diabetic nephropathy. Thirteen patients with membranous glomerulonephritis and 8 insulin-dependent diabetic ...

journal_title：Nephron

authors： Torffvit O,Agardh CD,Alm P,Wieslander J

更新日期：1991-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) is elevated in patients with chronic renal failure (CRF) and was suggested to be one of the factors responsible for the anemic syndrome of these patients because it raises the osmotic fragility of the red blood cells (RBC). In the present study, the youngest and oldest RBC were separated from...

journal_title：Nephron

authors： Malachi T,Bogin E,Gafter U,Levi J

更新日期：1986-01-01 00:00:00

abstract：:The effect of intravenous 1 alpha(OH)D3 on circulating intact parathyroid hormone (PTH) and COOH-terminal immunoreactive PTH was examined in 21 patients on chronic hemodialysis. The patients were treated for 3 months with increasing doses of 1 alpha(OH)D3 under careful control of serum Ca2+. 1 alpha(OH)D3 was given in...

journal_title：Nephron

authors： Brandi L,Daugaard H,Tvedegaard E,Storm T,Olgaard K

更新日期：1989-01-01 00:00:00

abstract：:A preparation for performance of renal clearances in the conscious dog is described. The important aspect of the technique is the use of a Pavlov sling and a specially designed restraining apparatus. Of most importance is the use of a 7 French Swan-Ganz balloon-tipped catheter for urinary bladder catheterization. The ...

journal_title：Nephron

authors： Garner D,Laks MM

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Pruritus is one of the most common and disturbing symptoms in hemodialysis (HD) patients. The pathogenesis of pruritus in HD patients is multifactorial; however, a little progress in understanding this pathogenesis has been achieved. OBJECTIVES:To evaluate the frequency and risk factors of pruritus among HD...

journal_title：Nephron

authors： Abdelsalam M,Tawfik M,Reda EM,Eldeeb AA,Abdelwahab A,Zaki ME,Abdelkader Sobh M

更新日期：2019-01-01 00:00:00

abstract：:Cytomegalovirus is the most important viral infection in kidney transplants, but rarely affects the allograft after the sixth month posttransplantation. We present a patient who developed renal failure eighteen months posttransplant; a kidney biopsy showed cytomegalovirus inclusions, acute tubular necrosis and mild in...

journal_title：Nephron

authors： Trimarchi H,Jordan R,Iotti A,Forrester M,Iotti R,Freixas E,Martínez J,Schropp J,Pereyra H,Efrón E

更新日期：2002-10-01 00:00:00