Abstract:
:In the present study, activity of polymorphonuclear leukocyte (PMNL) intracellular antioxidant enzymes, i.e. catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), was assessed in CRF patients on hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) and in healthy controls. The activity of SOD and GPX was reduced in HD and in CAPD (SOD: by 34.2 and 42%, respectively, and GPX 66 vs. 42%, respectively, taking the activity in normal controls as 100%). Catalase activity, on the other hand, was significantly augmented (298 and 175%, respectively) as compared to the healthy controls. This impairment in antioxidant enzymes activity, involved in the respiratory burst and phagocytosis, may contribute to the understanding of the reduced bactericidal ability of PMNL activity found in these patients.
journal_name
Nephronjournal_title
Nephronauthors
Shurtz-Swirski R,Mashiach E,Kristal B,Shkolnik T,Shasha SMdoi
10.1159/000188708subject
Has Abstractpub_date
1995-01-01 00:00:00pages
176-9issue
2eissn
1660-8151issn
2235-3186journal_volume
71pub_type
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