Antioxidant enzymes activity in polymorphonuclear leukocytes in chronic renal failure.

Abstract:

:In the present study, activity of polymorphonuclear leukocyte (PMNL) intracellular antioxidant enzymes, i.e. catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), was assessed in CRF patients on hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) and in healthy controls. The activity of SOD and GPX was reduced in HD and in CAPD (SOD: by 34.2 and 42%, respectively, and GPX 66 vs. 42%, respectively, taking the activity in normal controls as 100%). Catalase activity, on the other hand, was significantly augmented (298 and 175%, respectively) as compared to the healthy controls. This impairment in antioxidant enzymes activity, involved in the respiratory burst and phagocytosis, may contribute to the understanding of the reduced bactericidal ability of PMNL activity found in these patients.

journal_name

Nephron

journal_title

Nephron

authors

Shurtz-Swirski R,Mashiach E,Kristal B,Shkolnik T,Shasha SM

doi

10.1159/000188708

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

176-9

issue

2

eissn

1660-8151

issn

2235-3186

journal_volume

71

pub_type

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