Abstract:
:In 92 renal transplant recipients, serum or plasma levels of neopterin were significantly elevated during pretransplant uremia, rejection, cyclosporin A induced nephrotoxicity and cytomegalovirus (CMV) infections. In patients with normal serum creatinine (less than 115 mumol/l) 71% had elevated serum neopterin levels. None of 19 cyclosporin A treated patients with stable renal function had a normal level of neopterin compared to 50% for patients treated with azathioprine (p less than 0.05). Due to the dependency on renal function the serum levels of neopterin could not distinguish between rejection and cyclosporin A induced nephrotoxicity. Marked increases in neopterin levels were seen during infections and especially during CMV infection. Determination of neopterin levels may be helpful in the diagnosis of CMV infection.
journal_name
Nephronjournal_title
Nephronauthors
Bäckman L,Ringdén O,Björkhem Idoi
10.1159/000184375subject
Has Abstractpub_date
1987-01-01 00:00:00pages
319-22issue
3eissn
1660-8151issn
2235-3186journal_volume
46pub_type
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