Time course of serum prolactin and sex hormones following successful renal transplantation.

Abstract:

BACKGROUND:Chronic renal failure is commonly associated with disturbances in hypothalamic-pituitary-gonadal function. METHODS:The gonadotrophins, prolactin and estradiol or testosterone levels were measured immediately before renal transplantation, at discharge from the transplantation unit (19 +/- 8 days after Tx) and 6 months after transplantation in 21 patients, 7 females and 14 males, age range 21-60 years. RESULTS:The mean prolactin level was high during uremia and decreased rapidly after transplantation, from 441 to 167 mU/l in males and from 1,057 to 521 mU/l in females. Hypergonadotrophism was seen in most uremic patients, with the mean LH and FSH levels of 14.2 and 6.0 U/l in males and 14.7 and 4.0 U/l in females, respectively. A temporary change to hypogonadotrophic hypogonadism took place 2-3 weeks after transplantation and was followed by normalization of the hypothalamic-gonadal function. The levels of circulating sex steroids were suppressed when the patients were discharged from the transplantation unit but returned to the normal range at 6 months. CONCLUSIONS:We conclude that renal transplantation corrects the hyperprolactinemia induced by uremia and is followed by rapid onset of restoration of the hypothalamic-pituitary-gonadal axis.

journal_name

Nephron

journal_title

Nephron

authors

Saha MT,Saha HH,Niskanen LK,Salmela KT,Pasternack AI

doi

10.1159/000064079

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

735-7

issue

3

eissn

1660-8151

issn

2235-3186

pii

64079

journal_volume

92

pub_type

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