Abstract:
BACKGROUND:Chronic renal failure is commonly associated with disturbances in hypothalamic-pituitary-gonadal function. METHODS:The gonadotrophins, prolactin and estradiol or testosterone levels were measured immediately before renal transplantation, at discharge from the transplantation unit (19 +/- 8 days after Tx) and 6 months after transplantation in 21 patients, 7 females and 14 males, age range 21-60 years. RESULTS:The mean prolactin level was high during uremia and decreased rapidly after transplantation, from 441 to 167 mU/l in males and from 1,057 to 521 mU/l in females. Hypergonadotrophism was seen in most uremic patients, with the mean LH and FSH levels of 14.2 and 6.0 U/l in males and 14.7 and 4.0 U/l in females, respectively. A temporary change to hypogonadotrophic hypogonadism took place 2-3 weeks after transplantation and was followed by normalization of the hypothalamic-gonadal function. The levels of circulating sex steroids were suppressed when the patients were discharged from the transplantation unit but returned to the normal range at 6 months. CONCLUSIONS:We conclude that renal transplantation corrects the hyperprolactinemia induced by uremia and is followed by rapid onset of restoration of the hypothalamic-pituitary-gonadal axis.
journal_name
Nephronjournal_title
Nephronauthors
Saha MT,Saha HH,Niskanen LK,Salmela KT,Pasternack AIdoi
10.1159/000064079subject
Has Abstractpub_date
2002-01-01 00:00:00pages
735-7issue
3eissn
1660-8151issn
2235-3186pii
64079journal_volume
92pub_type
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