Abstract:
:We have previously documented the importance of tumor necrosis factor (TNF) alpha in the pathogenesis of nephrotoxic-serum nephritis in rats. In this study, we evaluated the possible relevance of the well-established cytocidal TNF activity to the mechanism of glomerular injury by assessing sensitivity of rat mesangial and epithelial cell populations to recombinant murine TNF alpha (rMuTNF). Radiolabelled confluent mesangial cell cultures that were incubated with rMuTNF released significantly more 3H-thymidine than control monolayers (maximum specific release was 11.4 +/- 4.9% at 1,000 pg/ml of rMuTNF). rMuTNF was, however, approximately 1,000-fold less cytolytic in mesangial cells than in the lymphotoxin-sensitive L929 cell line. Conversely, glomerular epithelial cells were not affected by exposure to rMuTNF under the same conditions. These results suggest that the cytolytic effect of TNF may contribute to glomerular injury in nephrotoxic-serum nephritis.
journal_name
Nephronjournal_title
Nephronauthors
Hruby ZW,Cybulsky AV,Lowry RPdoi
10.1159/000186185subject
Has Abstractpub_date
1990-01-01 00:00:00pages
410-3issue
4eissn
1660-8151issn
2235-3186journal_volume
56pub_type
杂志文章相关文献
NEPHRON文献大全abstract::The cytoprotective effect of ulinastatin was studied in LLC-PK1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release of lactate dehydrogenase and a decrease in the amount of remaining protein. In the cell injury models treated with ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000190195
更新日期:1997-01-01 00:00:00
abstract::Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000507305
更新日期:2020-01-01 00:00:00
abstract:CONTEXT:Soluble urokinase-type plasminogen activator -(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945-953] it has been found that there is a link between suPAR and renal disease in several gui...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000490118
更新日期:2018-01-01 00:00:00
abstract::A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064452
更新日期:2002-09-01 00:00:00
abstract::Hypertension secondary to renal transplantation was studied in our experimental model in the rat. In this model an intravenous injection of donor strain blood into recipients of allogeneic donor kidneys prior to transplantation was used to prolong the allograft survival. A reduced renal function associated with the hy...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183428
更新日期:1985-01-01 00:00:00
abstract::A preparation for performance of renal clearances in the conscious dog is described. The important aspect of the technique is the use of a Pavlov sling and a specially designed restraining apparatus. Of most importance is the use of a 7 French Swan-Ganz balloon-tipped catheter for urinary bladder catheterization. The ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180595
更新日期:1976-01-01 00:00:00
abstract::The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000189281
更新日期:1996-01-01 00:00:00
abstract:AIM:To clarify the role of leukocyte subsets in the development of glomerulosclerosis (GS) and interstitial lesions which may contribute to the prognosis of membranous nephropathy (MN), we investigated infiltrating cells in both glomeruli and interstitium in biopsy specimens. METHODS:Forty-one cases of MN were divided...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045213
更新日期:1998-12-01 00:00:00
abstract::Human peritoneal mesothelial cells lie on a basement membrane-like material consisting of fibronectin (FN), type I collagen (CI), type III collagen (CIII) and laminin (LA). To understand how these extracellular matrix (ECM) proteins affect mesothelial cell behavior, we investigated their effect on the adhesion and pro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189530
更新日期:1997-01-01 00:00:00
abstract::It has been generally accepted that acidosis results in hyperkalemia because of shifts of potassium from the intracellular to the extracellular compartment. There is ample clinical and experimental evidence, however, to support the conclusion that uncomplicated organic acidemias do not produce hyperkalemia. In acidosi...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000182061
更新日期:1981-01-01 00:00:00
abstract::We present data on the costs and impact of chronic renal failure, the primary renal diseases leading to end-stage renal disease in children, and review the adaptive responses and the pathophysiology and complications of uremia in experimental animals and in man. A treatment strategy is summarized. ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000045157
更新日期:1998-10-01 00:00:00
abstract:AIMS AND METHODS:This study was carried out to clarify whether the urinary excretion of type IV collagen (u-IV collagen) detected by specific radioimmunoassay, can be used as an indicator for the progression of diabetic nephropathy. RESULTS:u-IV collagen was higher in diabetic subjects with microalbuminuria and overt ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045709
更新日期:2000-09-01 00:00:00
abstract::The methodology for the collection, extraction, separation and measurement of urinary angiotensin II [the octapeptide, ANG(1-8)] is described. To determine the origin of urinary ANG(1-8), mean arterial pressure, renal hemodynamics and the arterial, renal venous and urinary concentrations of ANG(1-8) were examined prio...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000188215
更新日期:1994-01-01 00:00:00
abstract::The role of renal hemodynamic alterations in the curtailment of renal functions was studied in uranyl acetate-induced oliguric (ORF) and nonoliguric (NORF) renal failures of rabbits. 5 days after drug injection, renal functional and morphological changes were most remarkable. A depression of Cin and elevation of serum...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181771
更新日期:1980-01-01 00:00:00
abstract::The clinical profile of a patient with a 15 years' evolution of acne conglobata developing systemic amyloidosis with severe renal involvement is described, and the possible influence of suppurative skin foci surgical excision on the rapid progression to terminal renal failure is discussed. This etiological cause of se...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186227
更新日期:1991-01-01 00:00:00
abstract::Diabetic nephropathy (DN), a distinct manifestation of diabetic kidney disease, affects approximately 30% of patients with diabetes. While most attention has been focused on glomerular changes related to DN, there is growing evidence that tubulopathy is a key feature in the pathogenesis of this disease. The renal prox...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000494512
更新日期:2019-01-01 00:00:00
abstract::As the nephron population diminishes and azotemia develops, each remaining nephron adapts and increases its function by as much as 80%. To determine whether this adaption is permanent or transient, a rat model utilizing one remnant kidney and one normal control kidney was used. In stage one, immediately after ligation...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182879
更新日期:1982-01-01 00:00:00
abstract::During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7-1.2 mg/100 ml, BUN 53-89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but no...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180786
更新日期:1977-01-01 00:00:00
abstract::Familial lecithin-cholesterol acyltransferase deficiency is a hereditary disorder of lipid metabolism. Lipid material is deposited in the kidneys, the glomerular capillary basement membrane is irregularly thickened, detachment and even loss of endothelial cells are seen in the glomeruli. Proteinuria was present in 8 o...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180835
更新日期:1977-01-01 00:00:00
abstract::Cardiovascular disease is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Epidemiological and clinical studies have shown that this is most frequently related to damage of large conduit arteries. Macrovascular disease develops rapidly in uremic patients and is responsible for ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000045557
更新日期:2000-02-01 00:00:00
abstract::The specific lipid alterations in plasma and four different tissues, as well as the activities of plasma lecithin-cholesterol acyltransferase (LCAT) and tissue lipolytic enzymes were determined in experimental nephrotic and control rats. In nephrotic rats, the cholesterol level in the heart was significantly increased...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187323
更新日期:1993-01-01 00:00:00
abstract::To eliminate the discomfort caused by surgical methods and the risks involved using the trocar, for 1 year we have been using a new technique for insertion of peritoneal catheters (PC). We devised a steel instrument, vaguely resembling a rhinoscope, composed of two semicones. The handles are connected by a screw to pe...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183526
更新日期:1985-01-01 00:00:00
abstract::8 patients who developed proteinuria whilst receiving penicillamine for rheumatoid arthritis have been studied. Light microscopy of renal biopsy specimens showed evidence of an extramembranous nephropathy in 6 cases, with epimembranous spikes infrequently described previously in association with penicillamine. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181984
更新日期:1980-01-01 00:00:00
abstract::Most hypertensive subjects are overweight, and as a consequence have an increased prevalence of hypercholesterolaemia, impaired glucose tolerance, and left ventricular hypertrophy. Reduction of the blood pressure by antihypertensive drugs without control of the obesity leaves these additional risk factors for cardiova...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184543
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Alterations to the procurement biopsy are one of the main reasons that kidneys are not suitable for transplant and are discarded. The literature on procurement and reperfusion biopsy is inconsistent and heterogeneous. The objective of this study is to describe the correlation of the different histological ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000513120
更新日期:2021-01-28 00:00:00
abstract::In a 21-year-old Caucasian women with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of cap...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187071
更新日期:1992-01-01 00:00:00
abstract::Plasma concentrations of norepinephrine (NE) appear to reflect sympathetic nervous system (SNS) tone. Plasma NE increases substantially when the SNS is stressed by acute postural change or physical exercise. Standing up from the recumbent position elevates NE by about 90% in healthy normotensive and hypertensive subje...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181614
更新日期:1979-01-01 00:00:00
abstract::Creatinine clearance has been repeatedly measured in three groups of chronic uremics. In the first control group (31 cases), following a conventional low-protein diet, creatinine clearance declined linearly with time. In the second group (12 cases), following very low nitrogen diet supplemented with essential amino ac...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182036
更新日期:1981-01-01 00:00:00
abstract::Copper (Cu) and zinc (Zn) were measured in urine, serum and tissues from rats with nephrotic syndrome (NS) induced with a single subcutaneous dose of puromycin aminonucleoside (PAN; 15 mg/100 g BW). Control animals were pair-fed. Urine was collected daily, and the rats were sacrificed on day 10. PAN-nephrotic rats had...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187772
更新日期:1994-01-01 00:00:00
abstract::The Spanish brush goat (Capra hiricus) was studied as an animal model for the anephric state. This rugged animal has a hardy appetite and offers ready blood access for dialysis and sampling. BUN, plasma creatinine and potassium could be brought to normal values by daily hemodialysis. Continual weight loss, severe anem...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181750
更新日期:1980-01-01 00:00:00