Abstract:
:The role of renal hemodynamic alterations in the curtailment of renal functions was studied in uranyl acetate-induced oliguric (ORF) and nonoliguric (NORF) renal failures of rabbits. 5 days after drug injection, renal functional and morphological changes were most remarkable. A depression of Cin and elevation of serum creatinine concentration were more marked in ORF than in NORF. Renal blood flow was high as compared to controls. Cortical blood flow redistributed to the inner cortex. There was no significant difference in renal blood flow or cortical flow distribution between renal failure models. The findings suggest the minor roles of renal blood flow and cortical flow distribution in maintaining renal failure in these nephrotoxic models. Prominent tubular necrosis was found in ORF but not in NORF. Arterial inulin concentration during retrograde ureteral infusion of 14C-inulin solution was significantly high in ORF as compared to controls and NORF. However, this inulin leakage was too small to explain severely curtailed inulin clearance.
journal_name
Nephronjournal_title
Nephronauthors
Sudo M,Honda N,Hishida A,Nagase Mdoi
10.1159/000181771subject
Has Abstractpub_date
1980-01-01 00:00:00pages
144-50issue
3eissn
1660-8151issn
2235-3186journal_volume
25pub_type
杂志文章相关文献
NEPHRON文献大全abstract::In order to evaluate effects of metabolic acidosis on glucose metabolism in uremia, we studied, by an intravenous glucose tolerance test (IVGTT), 46 patients with severe chronic renal failure divided into three groups according to their blood bicarbonate (BB) values: group A formed by 15 patients without or with light...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187141
更新日期:1993-01-01 00:00:00
abstract::Idiopathic hypercalciuria, though a common cause of nephrolithiasis, has not been recognized to cause hypocalcemia and severe bone disease. We describe an adolescent with idiopathic hypercalciuria who presented initially with severe hypocalcemia and osteoporosis and this was later complicated by recurrent renal calcul...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186878
更新日期:1992-01-01 00:00:00
abstract::During hemodialysis therapy, a large amount of water is removed from the patient's blood in a short time; however, blood pressure remains stable in most patients. As water is removed, the circulating serum proteins become more concentrated, resulting in a marked increase in the driving force which pulls water from the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189320
更新日期:1996-01-01 00:00:00
abstract::Mixed IgM-IgG cryoglobulins were present in the serum of a patient with the nephrotic syndrome, recurrent purpura, chronic active hepatitis and ascites. A renal biopsy demonstrated deposition of IgM, IgG, and complement components C3 and C4 in intracapillary 'coagula' and glomerular capillary walls. No glomerular depo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180591
更新日期:1976-01-01 00:00:00
abstract::The relationship between glycosaminoglycans and beta 2-microglobulin, glycosaminoglycans and N-acetyl-beta-D-glucosaminidase as well as the relationship between the chondroitin sulfate/heparan sulfate ratio and SDS electrophoresis in the urine of subjects from the endemic area of Balkan nephropathy was studied in orde...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187564
更新日期:1993-01-01 00:00:00
abstract::The size distribution pattern of circulating rPRL was studied in intact control (C) rats and in three uremic models, namely urine autoinfusion (UA), bilateral ureteral ligation (BUL), and bilateral nephrectomy (BNx). Plasmas were chromatographed by gel filtration in Sephadex G-100. Rat PRL was measured by RIA. The rPR...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183306
更新日期:1984-01-01 00:00:00
abstract::Tubular necrosis elicits a process of renal tissue repair characterized by an increase of cell turnover in tubular epithelium. The present study was undertaken to examine the distribution of epidermal growth factor (EGF) and/or of its larger precursor proEGF in the kidney undergoing tubular regeneration. Sprague-Dawle...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186253
更新日期:1991-01-01 00:00:00
abstract::Dopexamine hydrochloride is a synthetic dopamine analogue recently developed to improve myocardial and renal performance in patients suffering from low cardiac output states. The present study was designed to assess the pharmacological profile and the anatomical localization of [3H]-dopexamine binding sites within the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187518
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiac surgery-associated severe acute kidney injury (SAKI) is associated with high mortality and poor quality of life. A prognostic score for SAKI may enable prevention of complications. METHODS:This observational study of 2,552 patients undergoing cardiac surgery from January 2006 to December 2011 i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000499345
更新日期:2019-01-01 00:00:00
abstract::An animal model with experimental uremia is an important research tool for the study of the sequence of pathophysiological events taking place in the uremic syndrome. An appreciable number of animal models and methods for the induction of chronic uremia have been published. It is surprising that no such method has bee...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183491
更新日期:1985-01-01 00:00:00
abstract::Recurrent intradialytic hypotension is probably the most severely disabling feature in dialysis patients and the etiology is multifactorial. We assessed the efficacy and safety of midodrine, a selective alpha1-adrenergic pressor agent in 12 patients with recurrent intradialytic hypotension. Symptomatic intradialytic h...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000190288
更新日期:1997-01-01 00:00:00
abstract::Males on long-term dialysis tend to develop more severe forms of acquired cystic disease of the kidney than females. The severity of the disease is unaffected by therapeutic modality, either hemodialysis or CAPD, however, cystic transformation becomes less extensive after successful renal transplantation. The fundamen...
journal_title:Nephron
pub_type: 社论
doi:10.1159/000186434
更新日期:1991-01-01 00:00:00
abstract::The concentration of ionic calcium (Ca2+ in the smooth muscular cells of the resistance vessels is a determining factor of their contraction. It depends on the influx of Ca2+ to the interior of the cells through the calcium channels in the sarcolemma. The effect of a specific Ca2+-channel blocking agent - nifedipine -...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183607
更新日期:1985-01-01 00:00:00
abstract::While the bulk of renal hypertrophy induced by contralateral nephrectomy or a high-protein diet consists of tubular cell growth, there is some evidence suggesting that mesangial cells play a role in this phenomenon. Previous data suggest that this role of mesangial cells is associated with their proliferation. We, the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045668
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Outcomes in patients treated with haemodialysis(HD) are potentially influenced by the delivered dose of dialysis. The UK Renal Association publishes clinical practice guidelines recommendations for dialysis dose. The urea reduction ratio (URR) is a widely used measure of dialysis dose and has been historical...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000370276
更新日期:2015-01-01 00:00:00
abstract::To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in pla...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187399
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Pruritus is one of the most common and disturbing symptoms in hemodialysis (HD) patients. The pathogenesis of pruritus in HD patients is multifactorial; however, a little progress in understanding this pathogenesis has been achieved. OBJECTIVES:To evaluate the frequency and risk factors of pruritus among HD...
journal_title:Nephron
pub_type: 杂志文章,多中心研究
doi:10.1159/000501409
更新日期:2019-01-01 00:00:00
abstract::We found a strain of nonobese, nondiabetic (NON) mice which has spontaneous lipid deposition in glomerular capillary lumina. This strain was developed together with a diabetic strain of nonobese diabetic (NOD) mice for the generation of mouse models of diabetes mellitus. In the NON strain, contrary to the name, impair...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186417
更新日期:1991-01-01 00:00:00
abstract::To probe renal hemodynamic measurements in relation to simultaneous systemic hemodynamic measurements in normal, adult, conscious dogs on a magnesium-deficient diet, 6 experimental animals were given 4 weeks of a magnesium-deficient diet compared to 9 animals whose dietary magnesium was normal. Systemic hemodynamics w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185169
更新日期:1988-01-01 00:00:00
abstract::Circumstantial evidence that pIgA has a key role in glomerular injury of IgAN is now strong. Although the answers to the questions posed in this review are necessarily incomplete, they do indicate that (1) pIgA is a major component of mesangial IgA. (2) circulating pIgA is increased and this pIgA is particularly enhan...
journal_title:Nephron
pub_type: 社论
doi:10.1159/000187509
更新日期:1993-01-01 00:00:00
abstract::We analyzed 10 patients (male:female 9:1, mean age 64.2 years) who developed hepatocellular carcinoma during the observation period of 2 years among 2,164 chronic hemodialysis patients in 23 dialysis centers. Among them, 409 patients were positive for serum anti-HCV antibodies (19%). They were all positive for serum a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189340
更新日期:1996-01-01 00:00:00
abstract::Secondary hyperparathyroidism is common in chronic renal failure and is due to inadequate synthesis of calcitriol, the active metabolite of vitamin D. Intravenous administration of alphacalcidol, a synthetic analogue which is metabolized to calcitriol, was given during 12 weeks to 51 patients on chronic hemodialysis i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186004
更新日期:1990-01-01 00:00:00
abstract::A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064452
更新日期:2002-09-01 00:00:00
abstract::Plasma and urine beta-2-microglobulin (B2m) were measured in 37 renal transplant recipients and 34 healthy subjects. Serum B2m was found to be a more sensitive index of renal function than serum creatinine. Renal transplant recipients had significantly higher urine B2m when compared with normal controls. Normal subjec...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183376
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIMS:De novo expression of CD44 is considered as a marker of parietal epithelial cell (PEC) activation. The aim of our study was to explore CD74 expression, which can form a complex with CD44, in PECs during the progression of focal segmental glomerulosclerosis (FSGS). To clarify the role of CD74 expression ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000448221
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The introduction of automated biopsy devices and the localization of the kidney by ultrasound were aimed at optimizing efficacy and safety of the percutaneous renal biopsy procedure. We evaluated these technological advances in our renal biopsies performed in children. METHODS:We sequentially used the Silve...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045090
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:A constant finding in beta (2)-microglobulin (beta 2m) amyloidosis is an increase in tissue heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PGs) at sites of amyloid deposits. However, the binding characteristics of PGs with beta 2m have not been elucidated yet. METHODS:Using affinity retard...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000049037
更新日期:2002-02-01 00:00:00
abstract::Thymopentine is a synthetic immunomodulator that positively affects T-lymphocyte maturation, reproduction and differentiation. In elderly uremic patients nonresponders to hepatitis B vaccine, the administration of this drug has been shown to improve the response to the new vaccination. ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000186942
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Acid-base disturbances are frequent in critically ill patients. Arterial blood gas (ABG) is the gold standard in the diagnosis of these disturbances, but it is invasive with potential hazards. For patients with a central venous catheter, venous blood gas (VBG) sampling may be an alternative, less-invasive di...
journal_title:Nephron
pub_type: 杂志文章,多中心研究
doi:10.1159/000488501
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Urinary neutrophil gelatinase associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are markers of acute kidney injury. The albuminuria is a well-known abnormality after physical exercise. The aim of this study was to investigate changes in uNGAL and uKIM-1 after intensive exerc...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000481179
更新日期:2018-01-01 00:00:00