Abstract:
:Familial lecithin-cholesterol acyltransferase deficiency is a hereditary disorder of lipid metabolism. Lipid material is deposited in the kidneys, the glomerular capillary basement membrane is irregularly thickened, detachment and even loss of endothelial cells are seen in the glomeruli. Proteinuria was present in 8 out of 9 cases studied, usually it has not been detected before the age of 15-20. After 15-30 years with symptomless proteinuria, terminal renal failure has developed in 6 of the patients. Possible pathogenetic mechanisms of the renal damage is discussed; a large-molecular-weight low-density lipoprotein is suggested to be an important factor.
journal_name
Nephronjournal_title
Nephronauthors
Myhre E,Gjone E,Flatmark A,Hovig Tdoi
10.1159/000180835subject
Has Abstractpub_date
1977-01-01 00:00:00pages
239-48issue
4eissn
1660-8151issn
2235-3186journal_volume
18pub_type
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