Renal excretion of purine bases. Effects of probenecid, benzbromarone and pyrazinamide.

abstract：:A very simple analytical procedure with dimethylmethylene blue as photometric reagent was applied for the evaluation of glycosaminoglycan (GAG) urinary excretions and concentrations in both sexes, calcium oxalate stone formers, and a control group. The GAG concentrations varied significantly in stone formers (males an...

journal_title：Nephron

authors： Grases F,Llompart I,Conte A,Coll R,March JG

更新日期：1994-01-01 00:00:00

abstract：:The methodology for the collection, extraction, separation and measurement of urinary angiotensin II [the octapeptide, ANG(1-8)] is described. To determine the origin of urinary ANG(1-8), mean arterial pressure, renal hemodynamics and the arterial, renal venous and urinary concentrations of ANG(1-8) were examined prio...

journal_title：Nephron

authors： Reams G,Villarreal D,Wu Z,Bauer JH

更新日期：1994-01-01 00:00:00

abstract：:We report a case of graft intolerance syndrome in which transplant nephrectomy was performed 11 years after kidney transplantation. A 46-year-old man was admitted to our hospital in February 2018 with a mild fever, left lower abdominal pain, and gross hematuria with enlargement of the transplanted kidney. Urinary trac...

journal_title：Nephron

authors： Tomonari M,Kobayashi A,Yamamoto I,Hatanaka S,Kawabe M,Yamakawa T,Katsumata H,Katsuma A,Mafune A,Nakada Y,Koike Y,Miki J,Kimura T,Tanno Y,Yamamoto H,Yokoo T

更新日期：2020-01-01 00:00:00

abstract：:Results from many laboratories, including our own, support the following view of the status of renal blood flow (RBF) in acute renal failure (ARF). During the initiation phase of virtually all forms of experimental ARF, RBF appears to be substantially decreased. The mechanisms for the decrease in RBF vary depending on...

journal_title：Nephron

authors： Hsu CH,Kurtz TW

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline nephropathy in ceftriaxone-associated AKI and explored the related pathophysiology by using a proteomic approach. METHODS:Ceftriaxone was crystallized...

journal_title：Nephron

authors： Chatchen S,Pongsakul N,Srisomsap C,Chiangjong W,Hongeng S,Svasti J,Chutipongtanate S

更新日期：2018-01-01 00:00:00

abstract：:1 day after bilateral ureteral occlusion (BUO), the extracellular fluid (ECF) volume of rats was increased by 2.8 ml/100 g body weight above those values observed after either a sham operation or after 1 day of unilateral ureteral occlusion (UUO). The plasma urea concentration of BUO rats averaged about five times the...

journal_title：Nephron

authors： Sophasan S,Sorrasuchart S

更新日期：1984-01-01 00:00:00

abstract：:Lipoproteins might be involved in the pathogenesis of glomerular damage. Uptake of low-density lipoprotein (LDL) by cultured human glomerular cells has been studied using LDL, labelled with the fluorescent probe 1,1'-dioctadecyl-3,3,3'3'-tetramethyl-indocarbocyanine perchlorate (diI). Cells have been characterised usi...

journal_title：Nephron

authors： Rayner HC,Horsburgh T,Brown SL,Lavender FL,Winder AF,Walls J

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIM:Acute renal failure (ARF) is one of the common problems associated with sepsis or multiple organ dysfunction syndrome (MODS). We have investigated the effects of inhibiting selectin-mediated cell adhesion on lipopolysaccharide-induced ARF in rabbits, using sialyl Lewis X oligosaccharide and PB1.3, an ant...

journal_title：Nephron

authors： Hayashi H,Imanishi N,Ohnishi M,Tojo SJ

更新日期：2001-04-01 00:00:00

abstract：:We have determined the plasma levels of endothelin-1 (ET-1) in patients with end-stage renal disease treated with continuous ambulatory peritoneal dialysis (CAPD). In 10 CAPD patients mean plasma ET levels (7.01 +/- 0.5 pg/ml) were found higher than in normal subjects (3.6 +/- 0.6 pg/ml). Peritoneal clearance of ET-1 ...

journal_title：Nephron

authors： Vlassopoulos D,Deray G,Carayon A,Maistre G,Jacobs C

更新日期：1995-01-01 00:00:00

abstract：:We investigated changes in the levels of mRNA transcripts encoding types I and IV collagen in the kidney following the administration of ciclosporin (CS) in mice. Daily doses of CS increased the levels of mRNAs encoding collagen types I and IV in whole kidneys harvested 4 weeks after treatment. At this time point, nei...

journal_title：Nephron

authors： Wolf G,Neilson EG

更新日期：1992-01-01 00:00:00

abstract：:Diabetic nephropathy is the leading cause of kidney failure. Treatments with drugs that block the renin-angiotensin system have proven beneficial in slowing kidney disease progression among those with diabetes; their benefit is limited and they do not stop disease progression. Despite multiple clinical trials of vario...

journal_title：Nephron

authors： Toto RD

更新日期：2017-01-01 00:00:00

abstract：:Malignant hypertension and high plasma renin activity was found in a 39-year-old woman with an aldosterone-producing adenoma. Only 3 similar cases have been previously reported, and all patients died before or after identification of the adenoma. The present paper documents the first reported case of a successfully ma...

journal_title：Nephron

authors： Ideishi M,Kishikawa K,Kinoshita A,Sasaguri M,Ikeda M,Takebayashi S,Arakawa K

更新日期：1990-01-01 00:00:00

abstract：:Most hypertensive subjects are overweight, and as a consequence have an increased prevalence of hypercholesterolaemia, impaired glucose tolerance, and left ventricular hypertrophy. Reduction of the blood pressure by antihypertensive drugs without control of the obesity leaves these additional risk factors for cardiova...

journal_title：Nephron

authors： Ramsay LE

更新日期：1987-01-01 00:00:00

abstract：:We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. Th...

journal_title：Nephron

authors： Hashim OH,Shuib AS,Chua CT

更新日期：2001-12-01 00:00:00

abstract：:To investigate autonomic mechanisms underlying persistent hypotension in long-term hemodialysis patients, high-frequency (HF, > 0.15 Hz) and low-frequency (LF, 0.04-0.15 Hz) components of heart rate variability and plasma noradrenaline were analyzed in 10 persistently hypotensive hemodialysis patients (group H), 11 no...

journal_title：Nephron

authors： Takahashi H,Matsuo S,Toriyama T,Kawahara H,Hayano J

更新日期：1996-01-01 00:00:00

abstract：:We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated followi...

journal_title：Nephron

authors： Bennett CM,Falkinburg NR,Springberg PD

更新日期：1975-01-01 00:00:00

abstract：:We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in conce...

journal_title：Nephron

authors： Rubin J,Jones Q,Quillen E,Bower JD

更新日期：1983-01-01 00:00:00

abstract：:We describe a pair of 17-year-old identical twin brothers with asymptomatic proteinuria, one of whom showed focal segmental glomerulosclerosis (FSGS) while the other showed immunoglobulin M (IgM) nephropathy. For each twin, audiological examination was normal. There was no family history of renal failure, deafness, or...

journal_title：Nephron

authors： Kim HY,Oh H,Lee YH,Huh W,Kim YG,Kim DJ,Ko YH,Kim MK

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND/AIMS:Genetic cell ablation using the human diphtheria toxin receptor (hDTR) is a new strategy used for analysing cellular function. Diphtheria toxin (DT) is a cytotoxic protein that leaves mouse cells relatively unaffected, but upon binding to hDTR it ultimately leads to cell death. We used a podocyte-specif...

journal_title：Nephron

authors： Stevens M,Neal CR,Salmon AHJ,Bates DO,Harper SJ,Oltean S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...

journal_title：Nephron

authors： Shikano M,Sobajima H,Yoshikawa H,Toba T,Kushimoto H,Katsumata H,Tomita M,Kawashima S

更新日期：2000-05-01 00:00:00

abstract：:Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...

journal_title：Nephron

authors： Puschett JB,Fernandez PC

更新日期：1977-01-01 00:00:00

abstract：:The effects of acute beta 2-type adrenoreceptor activation with intravenous albuterol on plasma and urinary sodium, potassium, calcium, magnesium, phosphate and lithium were investigated in 9 volunteers during acute hydration. When compared with the control infusion with inactive vehicle, beta 2-type adrenoreceptor ac...

journal_title：Nephron

authors： Duss G,Bianchetti MG,Cattaneo FA,Mullis PE,Krämer R,Peheim E,Oetliker OH

更新日期：1993-01-01 00:00:00

abstract：:End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiolog...

journal_title：Nephron

authors： Ó hAinmhire E,Humphreys BD

更新日期：2017-01-01 00:00:00

abstract：:HCV is seen as an emergent problem in Dialysis Units; in fact, the patients of these centers are at high risk for blood-transmitted infections, through coming microepidemies. For this reason and using the same method, we have studied the prevalence of anti-HCV and virus-derived hepatitis in a dialytic population of 10...

journal_title：Nephron

authors： Scotto G,Savastano AM,Forcella M,Tantimonaco G,Amato G,Salatino G,Pappani A,Stella I

更新日期：1992-01-01 00:00:00

abstract：:To eliminate the discomfort caused by surgical methods and the risks involved using the trocar, for 1 year we have been using a new technique for insertion of peritoneal catheters (PC). We devised a steel instrument, vaguely resembling a rhinoscope, composed of two semicones. The handles are connected by a screw to pe...

journal_title：Nephron

authors： Di Paolo N,Manganelli A,Strappaveccia F,De Mia M,Gaggiotti E

更新日期：1985-01-01 00:00:00

abstract：:We have previously documented the importance of tumor necrosis factor (TNF) alpha in the pathogenesis of nephrotoxic-serum nephritis in rats. In this study, we evaluated the possible relevance of the well-established cytocidal TNF activity to the mechanism of glomerular injury by assessing sensitivity of rat mesangial...

journal_title：Nephron

authors： Hruby ZW,Cybulsky AV,Lowry RP

更新日期：1990-01-01 00:00:00

abstract：:In 92 renal transplant recipients, serum or plasma levels of neopterin were significantly elevated during pretransplant uremia, rejection, cyclosporin A induced nephrotoxicity and cytomegalovirus (CMV) infections. In patients with normal serum creatinine (less than 115 mumol/l) 71% had elevated serum neopterin levels....

journal_title：Nephron

authors： Bäckman L,Ringdén O,Björkhem I

更新日期：1987-01-01 00:00:00

abstract：:The assessment of the hypothalamic-pituitary-adrenal axis in patients with chronic renal failure (CRF) on hemodialysis is often hampered by abnormal responses to the standard 1-mg dexamethasone suppression test. Various mechanisms have been proposed to explain this lack of suppressibility. The present study was design...

journal_title：Nephron

authors： Van Herle AJ,Birnbaum JA,Slomowitz LA,Mayes D,Chandler DW,Rosenblit PD,Nissenson A

更新日期：1998-09-01 00:00:00

abstract：:Serum and urinary concentrations of NCl, the non collagenous globular domain of collagen IV, were used as markers for turnover of basement membranes. NCl levels were studied in membranous glomerulonephritis and diabetic nephropathy. Thirteen patients with membranous glomerulonephritis and 8 insulin-dependent diabetic ...

journal_title：Nephron

authors： Torffvit O,Agardh CD,Alm P,Wieslander J

更新日期：1991-01-01 00:00:00

abstract：:Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...

journal_title：Nephron

authors： Sessa A,Battini G,Meroni M,Daidone G,Carnera I,Brambilla PL,Viganò G,Giordano F,Pallotti F,Torri Tarelli L,Calabresi L,Rolleri M,Bertolini S

更新日期：2001-07-01 00:00:00