Increases in levels of collagen types I and IV messenger ribonucleic acid in murine kidneys after treatment with ciclosporin.

abstract：:Effect of the immunosuppressive agent, ciclosporin (CS), on bovine serum albumin (BSA) nephritis in rats was evaluated. Eight weeks after immunization, 19 male Wistar rats received a daily intravenous dose of BSA (2 mg). Two weeks later, 11 rats received BSA and an oral dose of CS (10 mg/kg), and 8 rats received only ...

journal_title：Nephron

authors： Fujita M,Iida H,Asaka M,Izumino K,Takata M,Sasayama S

更新日期：1991-01-01 00:00:00

abstract：:A 5-year-old Japanese boy showed nephritis similar to, but distinct from, that in Alport syndrome. Nephrotic syndrome without hematuria was noticed at age 2, although renal biopsy at age 4 revealed widespread irregular thickening of the glomerular basement membrane with splitting of the lamina densa on electron micros...

journal_title：Nephron

authors： Kawakami H,Murakami T,Murano I,Ushijima T,Taguchi T,Hattori S,Kajii T

更新日期：1990-01-01 00:00:00

abstract：:Several underlying metabolic abnormalities may be present in patients with recurrent calcium calculus disease (RCCD). The aim of this study was to determine the prevalence of deficiencies of 2 well-known potent inhibitors of crystal formation and growth, citrate and pyrophosphate, in the various metabolic subgroups an...

journal_title：Nephron

authors： Laminski NA,Meyers AM,Sonnekus MI,Smyth AE

更新日期：1990-01-01 00:00:00

abstract：:Idiopathic hypercalciuria, though a common cause of nephrolithiasis, has not been recognized to cause hypocalcemia and severe bone disease. We describe an adolescent with idiopathic hypercalciuria who presented initially with severe hypocalcemia and osteoporosis and this was later complicated by recurrent renal calcul...

journal_title：Nephron

authors： Wong CK,Pun KK,Tam SC,Tsui EY,Kung AW,Lam KS,Wang CC

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:Fatigue is a common symptom in patients receiving hemodialysis (HD) and is generally associated with anemia. However, it can be difficult to resolve, even when anemia has been treated using erythropoiesis-stimulating agents and iron replacement therapy. In the present study, we examined the associations...

journal_title：Nephron

authors： Yamasaki A,Yoda K,Koyama H,Yamada S,Tsujimoto Y,Okuno S,Okada S,Inaba M

更新日期：2016-01-01 00:00:00

abstract：:Pyomyositis, an endemic disease of tropical origin, is increasingly reported in temperate zones, especially in patients with diabetes mellitus and in the immunocompromised. A 28-year-old renal transplant recipient presented with perforating skin lesions (Kyrle's disease), thigh pain, and swelling associated with fever...

journal_title：Nephron

authors： Habte-Gabr E,Zayas JA,Rosenbaum RW

更新日期：1996-01-01 00:00:00

abstract：:Sprague-Dawley rats given gentamicin from 10 to 70 mg/kg/day for 9 days showed a linear decrease in glomerular filtration rate with increasing dose, paralleled by histologic changes of acute tubular necrosis and cast formation only at the higher doses. Nephrotoxicity was correlated with the peak, rather than trough, s...

journal_title：Nephron

authors： Sugarman A,Brown RS,Silva P,Rosen S

更新日期：1983-01-01 00:00:00

abstract：:Hyaluronic acid (HA) is a ubiquitous component of extracellular matrix. After tissue injury, HA appears in greater abundance during the inflammatory response and the phase of clearance of cell and matrix debris, before collagen production and matrix degradation. The aim of this study was to examine whether normal rat ...

journal_title：Nephron

authors： Pedagogos E,Hewitson TD,Nicholls KM,Becker GJ

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND/AIMS:Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly women. Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old women. ...

journal_title：Nephron

authors： Malmgren L,McGuigan FE,Berglundh S,Westman K,Christensson A,Åkesson K

更新日期：2015-01-01 00:00:00

abstract：:Losses in thyroxine-binding globulin (TBG) in peritoneal dialysate and thyroid function were evaluated in patients undergoing continuous ambulatory peritoneal dialysis (CAPD), in comparison to patients on hemodialysis (HD) without TBG loss in the dialysate. The TBG concentration in the peritoneal dialysate was 0.26 +/...

journal_title：Nephron

authors： Inaba M,Nishizawa Y,Nishitani H,Miki T,Onishi Y,Mizutani Y,Yamakawa M,Morii H

更新日期：1986-01-01 00:00:00

abstract：:Mizoribine has been shown to possess an immunosuppressive action that inhibits the proliferation of lymphocytes selectively by interfering with inosine monophosphate dehydrogenase. Recent studies have demonstrated that mizoribine improves renal tubulointerstitial fibrosis in the rat model of unilateral ureteral obstru...

journal_title：Nephron

authors： Sato N,Shiraiwa K,Kai K,Watanabe A,Ogawa S,Kobayashi Y,Yamagishi-Imai H,Utsunomiya Y,Mitarai T

更新日期：2001-10-01 00:00:00

abstract：:A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...

journal_title：Nephron

authors： Chan MK

更新日期：1990-01-01 00:00:00

abstract：:While the bulk of renal hypertrophy induced by contralateral nephrectomy or a high-protein diet consists of tubular cell growth, there is some evidence suggesting that mesangial cells play a role in this phenomenon. Previous data suggest that this role of mesangial cells is associated with their proliferation. We, the...

journal_title：Nephron

authors： Weissgarten J,Modai D,Berman S,Cohn M,Galperin E,Averbukh Z

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...

journal_title：Nephron

authors： Kirwan CJ,Blunden MJ,Dobbie H,James A,Nedungadi A,Prowle JR

更新日期：2015-01-01 00:00:00

abstract：:In an effort to elucidate immunopathogenic of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed of circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by in...

journal_title：Nephron

authors： Zager RA,Couser WG,Andrews BS,Bolton WK,Pohl MA

更新日期：1979-01-01 00:00:00

abstract：:Postnephrectomy serum has been proved to enhance proliferation of mesangial cells in culture. Studies in offspring to uninephrectomized (UNx) mothers indicate that it remains active for a long period following UNx. On the other hand, postnephrectomy renal compensatory growth in vivo is known to be completed within a s...

journal_title：Nephron

authors： Weissgarten J,Modai D,Cohn M,Berman S,Averbukh Z

更新日期：1998-01-01 00:00:00

abstract：:In this study we investigated the interactions between volume changes (body weight), plasma atrial natriuretic peptide (pANP) and ambulatory blood pressure (BP) in 10 patients with end-stage renal disease undergoing regular hemodialysis (HD) treatment three times weekly. Most patients retained their diurnal BP variati...

journal_title：Nephron

authors： Ojanen S,Pietilä K,Pasternack A

更新日期：1996-01-01 00:00:00

abstract：:Plasma immunoreactive atrial natriuretic factor (ANF) levels, their chromatographic profiles (high-performance liquid chromatography; HPLC) and changes during sequential ultrafiltration (UF; 1 litre/h) and biochemical correction without fluid removal (BC; 3 h) were studied in 8 end-stage chronic renal failure patients...

journal_title：Nephron

authors： Tonolo G,McMillan M,Richards AM,Montorsi P,Polonia J,Soro A,Troffa C,Glorioso N

更新日期：1990-01-01 00:00:00

abstract：:Diseases affecting both the lung and the kidney have grave prognosis and serious diagnostic and therapeutic consequences. Here, 3 cases of pulmonary-renal syndrome caused by antiphospholipid syndrome are reported. The patients presented with dyspnea, renal insufficiency, pulmonary infiltrates on chest X-ray and areas ...

journal_title：Nephron

authors： Henning BF,Gröne HJ,Tepel M,Büchner N,Kirchner J,Zidek W

更新日期：2002-07-01 00:00:00

abstract：:In vitro formation of prostaglandins (PG) E2, F2 alpha, 6-keto-F1 alpha, and thromboxane B2 (TxB2) by glomeruli from rats with reduced renal mass (RRM) were evaluated by radioimmunoassay. Four weeks following ablation of renal mass, PGE2, PGF2 alpha, and TxB2 production by glomeruli from RRM rats was significantly gre...

journal_title：Nephron

authors： Stahl RA,Kudelka S,Paravicini M,Schollmeyer P

更新日期：1986-01-01 00:00:00

abstract：:We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated followi...

journal_title：Nephron

authors： Bennett CM,Falkinburg NR,Springberg PD

更新日期：1975-01-01 00:00:00

abstract：:Cardiovascular disease remains the major cause of mortality in hemodialysis patients. Abnormal oxidative stress and impaired antioxidant defense may contribute to accelerated atherogenesis associated with uremia. As oxidative modification of lipids appears to be a prerequisite for the development of atherosclerotic le...

journal_title：Nephron

authors： Lim PS,Chan EC,Lu TC,Yu YL,Kuo SY,Wang TH,Wei YH

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:A high prevalence of cardiovascular diseases (CVDs) and infections in patients with chronic kidney disease (CKD) arises partly due to a high inflammatory state and aberrations in immune cells function. Following in vitro stimulation of leukocytes with different T-cell mitogens, we observed a lower level of i...

journal_title：Nephron

authors： Mansouri L,Nopp A,Jacobson SH,Hylander B,Lundahl J

更新日期：2017-01-01 00:00:00

abstract：:Serum and urinary concentrations of NCl, the non collagenous globular domain of collagen IV, were used as markers for turnover of basement membranes. NCl levels were studied in membranous glomerulonephritis and diabetic nephropathy. Thirteen patients with membranous glomerulonephritis and 8 insulin-dependent diabetic ...

journal_title：Nephron

authors： Torffvit O,Agardh CD,Alm P,Wieslander J

更新日期：1991-01-01 00:00:00

abstract：:A long-term hemodialysis male patient was known to have systemic iron overload due to regular blood transfusions. As he was suspected to have aluminum overload, he received a single intravenous administration of desferrioxamine (that supported the hypothesis). Four days later, he became highly febrile with no focus of...

journal_title：Nephron

authors： Hoen B,Renoult E,Jonon B,Kessler M

更新日期：1988-01-01 00:00:00

abstract：:Serum apolipoproteins A (Apo-A) and B (Apo-B) and lecithin: cholesterol acyl transferase (LCAT) activities and 24-hour urinary cholesterol levels were estimated in 25 nephrotic children before and during steroid treatment with 4 weeks of daily prednisolone followed by another 4 weeks of alternate-day prednisolone. The...

journal_title：Nephron

authors： Nayak SS,Bhaskaranand N,Kamath KS,Baliga M,Venkatesh A,Aroor AR

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIM:Acute renal failure (ARF) is one of the common problems associated with sepsis or multiple organ dysfunction syndrome (MODS). We have investigated the effects of inhibiting selectin-mediated cell adhesion on lipopolysaccharide-induced ARF in rabbits, using sialyl Lewis X oligosaccharide and PB1.3, an ant...

journal_title：Nephron

authors： Hayashi H,Imanishi N,Ohnishi M,Tojo SJ

更新日期：2001-04-01 00:00:00

abstract：:To clarify the in vivo involvement of cellular adhesion molecules and cytokines in human glomerulonephritis, we have investigated the glomerular and interstitial expression of intercellular adhesion molecule 1 (ICAM-1) in 69 kidney biopsy specimens by immunohistochemical methods and its correlation with serum bioactiv...

journal_title：Nephron

authors： Yokoyama H,Takaeda M,Wada T,Ohta S,Hisada Y,Segawa C,Furuichi K,Kobayashi K

更新日期：1997-01-01 00:00:00

abstract：:Cardiovascular disease is the major complication and cause of mortality in the dialysis population, accounting for about 40% of deaths. Oxidative stress has been strongly implicated in the pathogenesis of these events. As patients in end-stage renal disease (ESRD) are in a state of elevated free radical activity, the ...

journal_title：Nephron

authors： Wang NP,Lim PS,Chen TT,Thien LM,Wang TH,Hsu WM

更新日期：2002-12-01 00:00:00

abstract：AIM:Most transplant centres use SV40 large T antigen (TAg) staining for the diagnosis and assessment of BK polyomavirus-associated nephropathy (BKPyVAN). This study was performed to evaluate the significance of capsid protein VP1 expression in BKPyVAN. METHODS:We performed immunohistochemical staining using anti-SV40 ...

journal_title：Nephron

authors： Masutani K,Matsukuma Y,Tsuchimoto A,Okabe Y,Doi A,Kaku K,Nakamura M,Nakano T,Tsuruya K,Kitazono T

更新日期：2020-01-01 00:00:00