Association of Erythropoietin Resistance with Fatigue in Hemodialysis Patients: A Cross-Sectional Study.

Abstract:

BACKGROUND/AIMS:Fatigue is a common symptom in patients receiving hemodialysis (HD) and is generally associated with anemia. However, it can be difficult to resolve, even when anemia has been treated using erythropoiesis-stimulating agents and iron replacement therapy. In the present study, we examined the associations of anemia, the erythropoietin resistance index (ERI) and iron deficiency with fatigue during HD. METHODS:In this cross-sectional study, fatigue score was calculated on the basis of questionnaire responses in HD patients. Participants were divided into 3 groups according to their hemoglobin (Hb) levels (low, normal and high). Iron deficiency was assessed as a transferrin saturation (TSAT) of <20%. RESULTS:We included 571 HD patients (men/women 368/203; mean age 62.2 ± 10.8 years). Among the 3 groups, fatigue scores increased significantly with decreasing Hb levels. HD patients with low Hb levels (<90 g/l) had significantly higher fatigue scores than those with higher Hb levels (≥120 g/l). In the multiple regression analysis, we showed that a high ERI (β = 0.208) and a low TSAT (β = -0.155), but not the Hb level, were significantly associated with increased fatigue score. Moreover, this was independent of age, gender and modifiable confounders linked to anemia. Even after restricting patients to those without iron deficiency (TSAT ≥20%), the ERI (β = 0.258) retained a significant and independent association with the fatigue score. CONCLUSION:Iron deficiency and a high ERI despite iron sufficiency may cause fatigue in HD patients.

journal_name

Nephron

journal_title

Nephron

authors

Yamasaki A,Yoda K,Koyama H,Yamada S,Tsujimoto Y,Okuno S,Okada S,Inaba M

doi

10.1159/000448108

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

95-102

issue

2

eissn

1660-8151

issn

2235-3186

pii

000448108

journal_volume

134

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Acute renal failure associated with Yersinia pseudotuberculosis infection.

    abstract::Since 1987, we have experienced 11 children with acute renal failure (ARF) associated with Yersinia pseudotuberculosis (YP) infection. The illness began with the sudden onset of high fever, skin rash and gastrointestinal symptoms. Later in the course, periungual desquamation developed, mimicking Kawasaki disease. Elev...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188611

    authors: Cheong HI,Choi EH,Ha IS,Lee HJ,Choi Y

    更新日期:1995-01-01 00:00:00

  • Rapid radioimmunoassay for diagnosing acute tubular necrosis.

    abstract::A previously described method for recovering a proximal renal tubular epitheal antigen (HRTE-1) from normal human kidney was modified by using ion-exchange and immunoaffinity chromatography in order to create easily reproducible conditions for antigen isolation. Radioiodinated HRTE-1 was then used to establish a 3-hou...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181942

    authors: Zager RA,Rubin NT,Ebert T,Maslov N

    更新日期:1980-01-01 00:00:00

  • Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis.

    abstract::Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean +/...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186154

    authors: Goldman M,Vandenabeele P,Moulart J,Amraoui Z,Abramowicz D,Nortier J,Vanherweghem JL,Fiers W

    更新日期:1990-01-01 00:00:00

  • Hypercalciuria and nephrocalcinosis, a feature of Wilson's disease.

    abstract::Hypercalciuria and nephrocalcinosis are not uncommon in patients with Wilson's disease but have only once been reported as the presenting sign. We diagnosed Wilson's disease in a 17-year-old male patient 6 years after his first episode of gross hematuria and 2 years after detection of hypercalciuria and nephrocalcinos...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187530

    authors: Hoppe B,Neuhaus T,Superti-Furga A,Forster I,Leumann E

    更新日期:1993-01-01 00:00:00

  • A new kindred with hereditary hypophosphatemic rickets with hypercalciuria: implications for correct diagnosis and treatment.

    abstract::Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a new autosomal form of hypophosphatemic rickets, recently described. This disease is characterized, and differs from other forms of hereditary hypophosphatemic rickets and/or osteomalacia by increased serum levels of 1,25-dihydroxyvitamin D, hypercalci...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187029

    authors: Tieder M,Arie R,Bab I,Maor J,Liberman UA

    更新日期:1992-01-01 00:00:00

  • UK Renal Registry 18th Annual Report: Chapter 9 Biochemical Variables amongst UK Adult Dialysis Patients in 2014: National and Centre-specific Analyses.

    abstract::In 2014 57.5% of HD patients and 62.7% of PD patients achieved the audit measure for phosphate. 29.0% of HD and 30.3% of PD patients had a serum phosphate above the audit standard range. 79.1% of HD and 79.7% of PD patients had adjusted calcium between 2.2–2.5 mmol/L. 57.4% of HD and 65.0% of PD patients had a serum P...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000444823

    authors: Nicholas J,Evans R,Shaw C,Dawnay A

    更新日期:2016-01-01 00:00:00

  • Consequences of Glomerular Hyperfiltration: The Role of Physical Forces in the Pathogenesis of Chronic Kidney Disease in Diabetes and Obesity.

    abstract:BACKGROUND:Glomerular hyperfiltration (GH) is a hallmark of renal dysfunction in diabetes and obesity. Recent clinical trials demonstrated that SGLT2 inhibitors are renoprotective, possibly by abating hyperfiltration. The present review considers the current evidence for a cause-to-effect relationship between hyperfilt...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000499486

    authors: Chagnac A,Zingerman B,Rozen-Zvi B,Herman-Edelstein M

    更新日期:2019-01-01 00:00:00

  • Urinary fibrinogen and fibrin fragments in children with renal disease.

    abstract::Fibrinogen fragments (X, Y, D and E) and fibrin fragments (D-dimer and E) were examined in the urine of 52 patients with various types of renal diseases. One or more of the fibrinogen fragments were detectable in all the urine specimens. D-Dimer together with fibrinogen fragments was found in 38 of the 52 patients. Th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182833

    authors: Yoshioka K,Iseki T,Akano N,Uraoka Y,Miyata H,Maki S

    更新日期:1982-01-01 00:00:00

  • Elevated serum levels of 3-deoxyglucosone, a potent protein-cross-linking intermediate of the Maillard reaction, in uremic patients.

    abstract::3-Deoxyglucosone (3-DG) has been identified as an intermediate of the Maillard reaction in vitro. We measured serum 3-DG levels using gas chromatography/mass spectrometry and found a marked elevation in serum 3-DG levels in uremic patients compared with healthy subjects. The uremic patients with diabetes showed signif...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188516

    authors: Niwa T,Takeda N,Miyazaki T,Yoshizumi H,Tatematsu A,Maeda K,Ohara M,Tomiyama S,Niimura K

    更新日期:1995-01-01 00:00:00

  • Systemic factors and renal hemodynamic effects of high-protein meal versus low-protein meal in conscious dogs.

    abstract::The effects of a high-protein (HP) and low-protein (LP) meal on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and renal vascular resistance (RVR) were examined in conscious dogs. Ingestion of the HP and LP meal produced a temporary increase in systemic hemodynamic parameters due in part to a 'c...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188228

    authors: Zawada ET,Saelens DA,Alavi FK,Lembke JM

    更新日期:1994-01-01 00:00:00

  • Anemia and Long-Term Renal Prognosis in Patients with Post-Renal Acute Kidney Injury of Nonmalignant Cause.

    abstract:BACKGROUND/AIMS:The renal prognosis of post-renal acute kidney injury (PoR-AKI) has not been verified so far. The objective of this study was to assess the association of baseline anemia with long-term renal prognosis in patients with PoR-AKI. METHODS:We performed a multicenter retrospective cohort study. Consecutive ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000452810

    authors: Sasaki S,Kawarazaki H,Hasegawa T,Shima H,Naganuma T,Shibagaki Y

    更新日期:2017-01-01 00:00:00

  • Uremic pericardial effusion. Treatment by catheter drainage and local nonabsorbable steroid administration.

    abstract::Pericardial drainage via percutaneous catheter placement and local nonabsorbable steroid instillation was employed as definitive therapy for uremic patients who had intractable pericardial effusions. Twelve patients are reported. Prior daily dialysis, and in one case systemic steroids, were not curative. 11 of 12 case...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180622

    authors: Buselmeier TJ,Simmons RL,Najarian JS,Mauer SM,Matas AJ,Kjellstrand CM

    更新日期:1976-01-01 00:00:00

  • Role of fibronectin in immune glomerulonephritis.

    abstract::There is already a considerable amount of evidence suggesting that fibronectin (Fn) plays an important role in the pathogenic process in some forms of glomerulonephritis (GN). It has been postulated that Fn may participate in the progression or regression of glomerular diseases. The Fn is presented in the kidney as a ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187249

    authors: Altunkova I,Minkova V,Belovezhdov N

    更新日期:1993-01-01 00:00:00

  • Concomitant presence of three different glomerular diseases in the same patient. Report of a case and review of the literature.

    abstract::A 51-year-old man with diabetes mellitus and the nephrotic syndrome on renal biopsy was found to have diabetic glomerulosclerosis, amyloidosis and membranous glomerulopathy. The presence of three distinct glomerular diseases in the same patient is unique. Possible factors involved in their pathogenesis are discussed a...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000183026

    authors: Bertani T,Olesnicky L,Abu-Regiaba S,Glasberg S,Pirani CL

    更新日期:1983-01-01 00:00:00

  • A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism.

    abstract::A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism, presenting severe hyponatremia, is described. A 57-year-old man complaining of nausea, vomiting and fatigability was admitted to our hospital because of hyponatremia (114 mEq/I). The low levels of serum cortisol and urinary 17-OHCS suggested gluc...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189056

    authors: Okada K,Takahashi S

    更新日期:1996-01-01 00:00:00

  • Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients?

    abstract::Pruritus is a common symptom among patients undergoing long-term hemodialysis. However, its etiology remains unclear. In an attempt to clarify its cause we tried to correlate pruritus and its intensity with several serological variables in 94 hemodialysis patients. Our results show that higher serum aluminum concentra...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189499

    authors: Friga V,Linos A,Linos DA

    更新日期:1997-01-01 00:00:00

  • Failure of sodium restriction to abolish exaggerated natriuresis in poststreptococcal glomerulonephritis.

    abstract::Exaggerated natriuresis in response to hypertonic saline infusion occurs with great regularity in patients with documented previous attacks of poststreptococcal glomerulonephritis. Five patients were studied before and after 1 week of dietary sodium restriction in order to examine the possibility that increased extrac...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180852

    authors: Schacht RG,Steele JM Jr,Lowenstein J,Baldwin DS

    更新日期:1977-01-01 00:00:00

  • Mitochondrial granulation in the proximal renal tubule in uremia.

    abstract::Mitochondria contain electron-dense particles, partly composed of an amorphous form of calcium phosphate. We have used electron microscopy from percutaneous renal biopsy material to analyze mitochondrial granulation in the proximal renal tubule of nonuremic and uremic children. Based on a technique of cutting mitochon...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181739

    authors: Whitney JO,Goodman JR,Piel CF

    更新日期:1979-01-01 00:00:00

  • Measures of tubular function in normoalbuminuric insulin-dependent diabetic patients and their relationship with sodium lithium countertransport activity.

    abstract::The aim of this study was to assess the relationship between markers of tubular function, markers of glycaemic control and erythrocyte sodium-lithium countertransport activity (SLC) in 40 normotensive, normoalbuminuric insulin-dependent diabetic (IDDM) subjects and 11 normal control subjects. Nine IDDM subjects had SL...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000189149

    authors: Catalano C,Winocour PH,Parlongo S,Gibb I,Gillespie S,Alberti KG

    更新日期:1996-01-01 00:00:00

  • Urinary kallikrein in normal pregnancy, pregnancy with hypertension, and toxemia.

    abstract::The 24-hour urinary excretion of kallikrein (K) and prostaglandin E2 (PGE2), which reflects their intrarenal synthesis, was measured in 7 normal women (NW), 10 women with essential hypertension (EH), 26 normal pregnant women (NP), 12 women with hypertension in pregnancy (HP), and 4 women with toxemia. All pregnant wom...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183426

    authors: Kovatz S,Arber I,Korzets Z,Rathaus M,Ben Aderet N,Bernheim J

    更新日期:1985-01-01 00:00:00

  • Familial medullary sponge kidney in association with congenital absence of teeth (anodontia).

    abstract::Medullary sponge kidney was found in association with congenital absence of teeth (anodontia) in 3 siblings of a single family. Anodontia occurs in the rare familial syndrome of ectodermal dysplasia, but its association with a renal (mesodermal) anomaly is not known. The present report lends further support to a possi...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184918

    authors: Khoury Z,Brezis M,Mogle P

    更新日期:1988-01-01 00:00:00

  • Elevated serum uric acid. A cardiovascular risk factor?

    abstract::A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181660

    authors: Tweeddale MG,Fodor JG

    更新日期:1979-01-01 00:00:00

  • Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload. Role of gastric acid secretion.

    abstract::In normal subjects, the gastric ionisation of calcium and phosphate seems to be a prerequisite for their intestinal absorption. We investigated the behavior of the plasma calcium and phosphate profile in 30 patients on regular dialysis treatment in the 6 h following a meal containing 1 g of calcium and 2 g of phosphat...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064290

    authors: Graziani G,Badalamenti S,Como G,Gallieni M,Finazzi S,Angelini C,Brancaccio D,Ponticelli C

    更新日期:2002-07-01 00:00:00

  • Canine renal and systemic hemodynamic measurements after 4 weeks of a magnesium deficient diet.

    abstract::To probe renal hemodynamic measurements in relation to simultaneous systemic hemodynamic measurements in normal, adult, conscious dogs on a magnesium-deficient diet, 6 experimental animals were given 4 weeks of a magnesium-deficient diet compared to 9 animals whose dietary magnesium was normal. Systemic hemodynamics w...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185169

    authors: Zawada ET Jr,TerWee JA,McClung DE

    更新日期:1988-01-01 00:00:00

  • Inflammatory cytokines and lipopolysaccharide induce Fas-mediated apoptosis in renal tubular cells.

    abstract:BACKGROUND/AIMS:Increased susceptibility of the kidney to acute renal failure (ARF) in the setting of sepsis even in the absence of systemic hypotension is well known. In the hypothesis that the proinflammatory cytokines and lipopolysaccharide (LPS) in gram-negative sepsis can directly cause renal tubular cell apoptosi...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064280

    authors: Jo SK,Cha DR,Cho WY,Kim HK,Chang KH,Yun SY,Won NH

    更新日期:2002-07-01 00:00:00

  • Effect of hemodialysis on serum concentrations of HPLC-analyzed accumulating solutes in uremia.

    abstract::The concentration changes, during hemodialysis treatment, of 18 characteristic uremia compounds, analyzed by high-pressure liquid chromatography in sera of renal patients were studied. Pre- to postdialysis concentration ratios (dialysis ratio, D) varied from 0.83 to 3.04 for the different solutes. A division into thre...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185746

    authors: Schoots AC,Peeters JA,Gerlag PG

    更新日期:1989-01-01 00:00:00

  • Acute effect of passive Heymann nephritis on renal blood flow and glomerular filtration rate in the rat: role of the anaphylatoxin C5a and the alpha-adrenergic nervous system.

    abstract::In earlier studies, we have shown that induction of passive Heymann nephritis (PHN) by intrarenal infusion of anti-Fx1A antibodies provokes an immediate fall in renal blood flow (RBF) and glomerular filtration rate (GFR). This was probably mediated via the complement system, as infusion of the F(ab')2 fraction of anti...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186808

    authors: Sekse I,Iversen BM,Daha MR,Ofstad J

    更新日期:1992-01-01 00:00:00

  • HDL cholesterol and TaqIB cholesteryl ester transfer protein gene polymorphism in renal transplant recipients.

    abstract::Decreased serum levels of high-density lipoprotein cholesterol (HDL-C) are a well-known risk factor for coronary heart disease (CHD) in the general population and have been suggested as one of the best predictor of CHD after renal transplantation. However, very heterogeneous HDL-C levels have been reported in renal tr...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045608

    authors: Radeau T,Vohl MC,Houde I,Lachance JG,Noël R,Després JP,Douville P,Bergeron J

    更新日期:2000-04-01 00:00:00

  • Transforming growth factor-beta1 may be involved in shunt obstruction in patients on chronic hemodialysis.

    abstract::Obstructed shunt vessels were studied immunohistochemically to clarify the mechanism of shunt obstruction in hemodialysis patients. The subjects were 12 hemodialysis patients with shunt obstruction, and 8 patients newly started on hemodialysis were used as the controls. Cryosections of shunt tissue were prepared and s...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000045256

    authors: Taniguchi Y,Yorioka N,Yamashita K,Masaki T,Yamakido M

    更新日期:1999-01-01 00:00:00

  • Characteristics of Patients Who Achieve Serum Phosphorus Control on Sucroferric Oxyhydroxide or Sevelamer Carbonate: A post hoc Analysis of a Phase 3 Study.

    abstract:INTRODUCTION:Control of hyperphosphatemia in patients on dialysis remains a major challenge. OBJECTIVE:This study evaluated predictors of serum phosphorus (sP) control among dialysis patients treated with noncalcium, oral phosphate binder therapy in a phase 3 clinical trial. METHODS:Post hoc analyses were performed u...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000507258

    authors: Covic AC,Sprague SM,Rastogi A,Ketteler M,Walpen S,Perrin A,Floege J

    更新日期:2020-01-01 00:00:00