Abstract:
:Hypercalciuria and nephrocalcinosis are not uncommon in patients with Wilson's disease but have only once been reported as the presenting sign. We diagnosed Wilson's disease in a 17-year-old male patient 6 years after his first episode of gross hematuria and 2 years after detection of hypercalciuria and nephrocalcinosis. Therapy with penicillamine resulted only in a moderate reduction of urinary calcium excretion but oxalate excretion increased.
journal_name
Nephronjournal_title
Nephronauthors
Hoppe B,Neuhaus T,Superti-Furga A,Forster I,Leumann Edoi
10.1159/000187530subject
Has Abstractpub_date
1993-01-01 00:00:00pages
460-2issue
3eissn
1660-8151issn
2235-3186journal_volume
65pub_type
杂志文章相关文献
NEPHRON文献大全abstract::We present data on the costs and impact of chronic renal failure, the primary renal diseases leading to end-stage renal disease in children, and review the adaptive responses and the pathophysiology and complications of uremia in experimental animals and in man. A treatment strategy is summarized. ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000045157
更新日期:1998-10-01 00:00:00
abstract::The high blood flow rate/gram of kidney tissue supplies mainly the renal cortex. The net effect of the interaction of the renin-angiotensin system, the kallikrein-kinin system and prostaglandins is to autoregulate renal blood flow within a narrow range. Drugs and neurogenic factors also influence renal hemodynamics. T...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182057
更新日期:1981-01-01 00:00:00
abstract::This study was undertaken to test the hypothesis that ischemia prior to transplantation causes tubular damage without clinical evidence of graft dysfunction. The urinary excretion of fructose-1,6-bisphosphatase (EC 3.1.3.11, FBPase), a cytosolic enzyme located exclusively in the proximal tubules, and the lysosomal enz...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000190248
更新日期:1997-01-01 00:00:00
abstract::The sera of 64 patients with extracapillary glomerulonephritis were investigated by enzyme-linked immunosorbent assay for the presence of antibody to human neutrophil myeloperoxidase (MPO). In all, circulating anti-MPO were found in 30% and antineutrophil cytoplasm antibodies (ANCA) detected by indirect immunofluoresc...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186124
更新日期:1990-01-01 00:00:00
abstract::Anderson-Fabry disease (AFd) is a rare X-linked disorder characterized by deficiency of alpha-galactosidase A that leads to systemic accumulation of neutral glycosphingolipids, predominantly globotriaosylceramide (Gb3), in body fluids and visceral tissues, including the kidney. End-stage renal failure is a common mani...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000058419
更新日期:2002-06-01 00:00:00
abstract::The porphyrin status of 38 renal transplant patients was investigated using a sensitive thin-layer chromatographic assay. Abnormalities of porphyrin synthesis observed in patients on hemodialysis were generally reversed on receipt of a transplant with sustained good renal function. Urinary coproporphyrin levels and th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182426
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of treatment for renal anemia in patients with chronic kidney disease (CKD). This meta-analysis was designed to evaluate their efficacy and safety. METHOD:Eight databases were searched for randomized controlled trials (RCTs). ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000508812
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The epithelial-mesenchymal transition (EMT) is a crucial event in the development of renal interstitial fibrosis (RIF). A growing body of evidence indicates that β-catenin plays an important role in various types of fibrosis. Although members of the microRNA (miRNA)-200 family have been suggested to suppress...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000479168
更新日期:2017-01-01 00:00:00
abstract::In 2014 57.5% of HD patients and 62.7% of PD patients achieved the audit measure for phosphate. 29.0% of HD and 30.3% of PD patients had a serum phosphate above the audit standard range. 79.1% of HD and 79.7% of PD patients had adjusted calcium between 2.2–2.5 mmol/L. 57.4% of HD and 65.0% of PD patients had a serum P...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000444823
更新日期:2016-01-01 00:00:00
abstract::An 'epidemic' of aseptic peritonitis occurred in our peritoneal dialysis unit, affecting 5 of 20 patients. Acute and convalescent viral titers were normal in all 5. The peritoneal fluid of the affected patients was not tested for endotoxin, but endotoxin was found in subsequent dialysis fluids from two machines in the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181728
更新日期:1979-01-01 00:00:00
abstract::The study aimed to evaluate the behavior of alpha-glutathione S-transferase (alpha-GST) in the serum of hemodialysis patients with hepatitis C virus (HCV) infection following treatment with high-dose IFN-alpha-2b. Ten patients with detected anti-HCV antibodies and HCV RNA by RT-PCR were selected and treated with high-...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045363
更新日期:1999-01-01 00:00:00
abstract::The urinary transforming growth factor beta (TGF-beta) excretion was measured in 33 patients including 10 with systemic lupus erythematosus (SLE), 8 with focal glomerular sclerosis (FGS), 9 with IgA nephropathy (IgAN), and 6 with membranous nephropathy (MN), and in 7 healthy subjects by enzyme-linked immunosorbent ass...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187852
更新日期:1994-01-01 00:00:00
abstract:CONTEXT:The widespread use of diuretics, potassium supplements, and medications that block renin angiotensin system puts the chronic kidney disease (CKD) population at high risk for dyskalemia, both hyperkalemia and hypokalemia. The optimal potassium level in a CKD patient is unknown. Subject of review: Two recent stud...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000490008
更新日期:2018-01-01 00:00:00
abstract::The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000189281
更新日期:1996-01-01 00:00:00
abstract::To clarify whether the changes of parathyroid size have any correlations with the long-term prognosis of calcitriol pulse therapy, we examined the time course of serum levels of parathyroid hormone (PTH) and size of parathyroid glands in 14 chronic dialysis patients during and after the oral calcitriol pulse therapy. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188261
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND/AIM:Interleukin (IL)-17 is a newly discovered cytokine that is secreted by activated memory CD4+ T cells and modulated the early stage of immune response. To elucidate the pathophysiology of minimal-change nephrotic syndrome (MCNS), we focused on IL-17, which is one of the key factors in regulating an inflam...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000058399
更新日期:2002-06-01 00:00:00
abstract::Cadmium-induced renal effects were followed (1989) in 16 workers previously exposed to cadmium, who had been shown 5 years earlier to have had tubular damage; all but 1 worker had persistent tubular damage (beta 2-microglobulin > 60 micrograms/mmol creatinine). The mean glomerular filtration rate (GFR) decreased from ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187282
更新日期:1993-01-01 00:00:00
abstract::Experiments were conducted which revealed the renal transport mechanism(s) of oxypurines by employing uricosuric agents and pyrazinamide. All specimens being drawn from healthy, normal subjects, the data showed that probenecid increased fractional uric acid, fractional hypoxanthine and fractional xanthine clearance, 3...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184888
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline nephropathy in ceftriaxone-associated AKI and explored the related pathophysiology by using a proteomic approach. METHODS:Ceftriaxone was crystallized...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000486324
更新日期:2018-01-01 00:00:00
abstract::The serum levels of 25-hydroxycholecalciferol, 24,25-dihydroxycholecalciferol, and 1,25-dihydroxycholecalciferol were measured simultaneously in three groups of adults with different renal function: normal (n = 24), glomerular filtration rate (GFR) greater than 70 ml/min; moderately decreased (n = 15), GFR 5-35 ml/min...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183383
更新日期:1985-01-01 00:00:00
abstract::329 patients were evaluated from 1978 to 1990. 40 new cases of non-A non-B hepatitis were observed, all regarding patients on hemodialysis. Since the beginning of 1989, we introduced measures to limit the diffusion of the virus: reduction to a minimum of blood transfusions and a new disinfection protocol for monitors,...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186929
更新日期:1992-01-01 00:00:00
abstract::Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000507305
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIM:The ultrasonic transit time is currently the best method for measuring the blood flow rate in the extracorporeal hemodialysis circuit. The purpose of this study was to analyze the differences between blood flow as indicated by the hemodialysis blood roller pump (prescribed blood flow) and by an ultrasoni...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045647
更新日期:2000-06-01 00:00:00
abstract::A 4-year-old girl, who had been in perfect health, presented with the acute onset of renal failure and abdominal mass. Investigations revealed a solitary left kidney which on histology had the typical features of xanthogranulomatous pyelonephritis. The child had no previous history suggestive of chronic renal disease ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181387
更新日期:1978-01-01 00:00:00
abstract::To clarify the in vivo involvement of cellular adhesion molecules and cytokines in human glomerulonephritis, we have investigated the glomerular and interstitial expression of intercellular adhesion molecule 1 (ICAM-1) in 69 kidney biopsy specimens by immunohistochemical methods and its correlation with serum bioactiv...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000190225
更新日期:1997-01-01 00:00:00
abstract::Joseph Andreas Jacobus Plenck was born in 1735 in Vienna where he studied surgery with Johan Christian Retter. At age 35 he was appointed Professor of Surgery and Obstetrics by Maria Theresia. Subsequently he became professor and life long secretary of the Medical Military Academy know as the Josephinum where he worke...
journal_title:Nephron
pub_type: 传,历史文章,杂志文章
doi:10.1159/000064450
更新日期:2002-09-01 00:00:00
abstract::We studied the effects of mid-term enalapril administration on protein-load-induced renal responses in 10 patients with early chronic renal failure (serum creatinine 2.70 +/- 1.0 mg/dl). The oral protein load was performed twice, before and after a 10-day therapy with enalapril. Glomerular filtration rate (125I-iothal...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185624
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often difficult to treat. However, the factors influencing cyst infection are still unknown. Therefore, we investigated clinical factors related to the duration of hospitalization and death d...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000493806
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000371448
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Scientists use preclinical models of acute kidney injury (AKI) to decipher mechanisms and develop therapy, but translation of therapies to patients remains poor. Models that better resemble patients, including those within clinical care, should be considered. SUMMARY:Mice provide many advantages to the stud...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000501559
更新日期:2019-01-01 00:00:00