Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade.

Abstract:

:Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, particularly those in dialysis and with kidney transplants.

journal_name

Nephron

journal_title

Nephron

authors

Perico L,Benigni A,Remuzzi G

doi

10.1159/000507305

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

213-221

issue

5

eissn

1660-8151

issn

2235-3186

pii

000507305

journal_volume

144

pub_type

杂志文章,评审

相关文献

NEPHRON文献大全
  • Effect of phosphatidylcholine on ultrafiltration in patients on continuous ambulatory peritoneal dialysis.

    abstract::Oral phosphatidylcholine at 900 mg/day was given to 4 patients with high lymph absorption for 8 weeks. Fluid and solute transfer before and after treatment were compared to 4 similar controls given placebo. None of the patients had overt ultrafiltration problems. After treatment, overnight peritoneal effluent phosphol...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000186527

    authors: Chan PC,Tam SC,Robinson JD,Yu L,Ip MS,Chan CY,Cheng IK

    更新日期:1991-01-01 00:00:00

  • Serum erythropoietin levels in the immediate kidney-posttransplant period.

    abstract::Following successful kidney transplantation, renal anemia is gradually corrected during the first 3-4 months. Serum erythropoietin (EPO) levels are increased after the first postoperative day following grafting. In this study, the serum EPO levels in the early posttransplant phase were investigated in 8 living-donor a...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186701

    authors: Goch J,Birgegård G,Wikström B,Tufveson G,Danielson BG

    更新日期:1992-01-01 00:00:00

  • Perimembranous-type renal amyloidosis: a peculiar form of AL amyloidosis.

    abstract::Six cases of perimembranous-type renal amyloidosis were reported. This type of renal amyloidosis was characterized by amyloid deposition predominantly involving the epithelial aspect of the glomerular capillary wall. Florid spicular arrangement was another representative feature. This type of amyloid deposition was fo...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185697

    authors: Shiiki H,Shimokama T,Yoshikawa Y,Onoyama K,Morimatsu M,Watanabe T

    更新日期:1989-01-01 00:00:00

  • Serum glycoprotein: glycosyl transferase activity in patients with renal disease.

    abstract::Glycoprotein: galactosyl and glycoprotein: sialic acid transferase activities were measured in the serum of patients with minimal lesion nephrotic syndrome, acute renal failure, and chronic renal insufficiency of varying severity. The activity of galactosyl transferase was elevated in all patients but one. Sialic acid...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000180711

    authors: Kirschbaum BB

    更新日期:1976-01-01 00:00:00

  • Hemodialysis-associated neutropenia and hypoxemia: the effect of dialyzer membrane materials.

    abstract::The fall in white blood cells (WBC) and arterial oxygen pressure that occurs during hemodialysis was investigated as a function of different dialysis membranes and different sterilization methods. 8 chronic hemodialysis patients were studied and each was dialyzed with three different membranes: cellulosic hollow fiber...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182728

    authors: Hakim RM,Lowrie EG

    更新日期:1982-01-01 00:00:00

  • Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.

    abstract::The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with end-stage renal disease (ESRD). In this study, we examined the allelic frequency and genotype distribution of the MTHFR gene in 151 Chinese ESRD ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045922

    authors: Lim PS,Hung WR,Wei YH

    更新日期:2001-03-01 00:00:00

  • Up-Regulation of CD74 Expression in Parietal Epithelial Cells in a Mouse Model of Focal Segmental Glomerulosclerosis.

    abstract:BACKGROUND/AIMS:De novo expression of CD44 is considered as a marker of parietal epithelial cell (PEC) activation. The aim of our study was to explore CD74 expression, which can form a complex with CD44, in PECs during the progression of focal segmental glomerulosclerosis (FSGS). To clarify the role of CD74 expression ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000448221

    authors: Yamazaki T,Sasaki S,Okamoto T,Sato Y,Hayashi A,Ariga T

    更新日期:2016-01-01 00:00:00

  • Proliferative glomerulonephritis in monoclonal gammopathy.

    abstract::A 62-year-old white male suffering from plasmacytosis with monoclonal gammopathy developed gastrointestinal bleeding, microscopic hematuria, proteinuria and progressive azotemia. A renal biopsy demonstrated capillary wall thickening, mesangial hyperplasia, crescent formation and subepithelial humps. Serum immunoglobul...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180902

    authors: Dhar SK,Smith EC,Fresco R

    更新日期:1977-01-01 00:00:00

  • Low molecular weight heparin in hemodialysis patients with a bleeding tendency.

    abstract::Efficacy and safety of a low-molecular-weight heparin (LMWH) were studied in 33 stable maintenance hemodialysis patients who had a bleeding tendency on unfractionated heparin. The optimal dose of LMWH for each patient was titrated before the study; the mean total LMWH dosage was 1,152 +/- 574 IU. No major bleeding or ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000045840

    authors: Leu JG,Chiang SS,Lin SM,Pai JK,Jiang WW

    更新日期:2000-12-01 00:00:00

  • Kidney and calcitonin.

    abstract::Calcitonin, whatever its origin, produces a decrease in the renal tubular reabsorption of sodium, phosphate and calcium in man and in the rat. Renal receptors for calcitonin have been demonstrated in the membranes of rat tubular cells using 125I salmon calcitonin as a tracer. Hormone-receptor interaction initiates the...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000180515

    authors: Ardaillou R

    更新日期:1975-01-01 00:00:00

  • The fibronectin production is increased by thrombospondin via activation of TGF-beta in cultured human mesangial cells.

    abstract::Thrombospondin (TSP) is a multifunctional glycoprotein that is synthesized by a variety of cells including mesangial cells (MCs). To clarify the effect of TSP on the pathogenesis of diabetic nephropathy, we studied the effect of glucose concentrations on TSP synthesis in cultured human MCs. Thereafter, the effects of ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044989

    authors: Tada H,Isogai S

    更新日期:1998-01-01 00:00:00

  • Prevalence of hyperoxaluria in idiopathic calcium oxalate kidney stone disease.

    abstract::Urinary excretion of oxalate, calcium and urate has been investigated in 88 patients affected by idiopathic calcium oxalate stone disease and in 20 normal subjects. Of these ions, only oxalate was found significantly higher in stone formers. Defining hyperoxaluria as urinary oxalate excretion greater than 2 SD above n...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183037

    authors: Baggio B,Gambaro G,Favaro S,Borsatti A

    更新日期:1983-01-01 00:00:00

  • Renal transplantation in diabetes mellitus. Influence of preexisting vascular disease on outcome.

    abstract::We reviewed the recommendations and outcomes for all patients with diabetes mellitus and end-stage renal disease referred to the Medical Center Hospital of Vermont from 1971 through December 1983. During this period, we recommended transplantation in 53 of 73 patients evaluated. Thirty-two transplants were performed i...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183693

    authors: Rimmer JM,Sussman M,Foster R,Gennari FJ

    更新日期:1986-01-01 00:00:00

  • Evaluation of iron status in patients on chronic hemodialysis: relative usefulness of bone marrow hemosiderin, serum ferritin, transferrin saturation, mean corpuscular volume and red cell protoporphyrin.

    abstract::The diagnostic usefulness of bone marrow hemosiderin, serum ferritin, transferrin saturation, mean corpuscular volume (MCV) and red cell protoporphyrin (EPP) in the evaluation of iron status in patients on chronic hemodialysis was studied in 39 subjects. The correlation between serum ferritin and the number of transfu...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183074

    authors: Moreb J,Popovtzer MM,Friedlaender MM,Konijn AM,Hershko C

    更新日期:1983-01-01 00:00:00

  • Relationship between urinary calcium and net acid excretion as determined by dietary protein and potassium: a review.

    abstract::Increasing urinary net acid (titratable acid + NH4 - HCO-3) excretion is accompanied by an increased urinary Ca excretion because of reduced renal tubular reabsorption of filtered Ca. The relationships between urinary Ca excretion rates and urinary net acid excretion rates are reviewed for data: (1) among healthy adul...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000046294

    authors: Lemann J Jr

    更新日期:1999-01-01 00:00:00

  • Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis.

    abstract::Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean +/...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186154

    authors: Goldman M,Vandenabeele P,Moulart J,Amraoui Z,Abramowicz D,Nortier J,Vanherweghem JL,Fiers W

    更新日期:1990-01-01 00:00:00

  • Prolactin plasma levels and its size heterogeneity in acutely uremic rats.

    abstract::The size distribution pattern of circulating rPRL was studied in intact control (C) rats and in three uremic models, namely urine autoinfusion (UA), bilateral ureteral ligation (BUL), and bilateral nephrectomy (BNx). Plasmas were chromatographed by gel filtration in Sephadex G-100. Rat PRL was measured by RIA. The rPR...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183306

    authors: Martin-Oar JE,Cachofeiro MV,Rodriguez-Puyol D,Hernando L,López-Novoa JM

    更新日期:1984-01-01 00:00:00

  • Failure of verapamil to protect from ischaemic renal damage.

    abstract::To reassess the reported protective effects of verapamil in renal ischaemia, we perfused the left kidney of uninephrectomized female Wistar rats with verapamil (0.1 and 1.0 mg/kg) immediately prior to clamping the renal artery for 60 min. When compared to controls, both doses of verapamil failed to afford protection w...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186279

    authors: Bock HA,Brunner FP,Torhorst J,Thiel G

    更新日期:1991-01-01 00:00:00

  • Meshwork structures in bovine glomerular and tubular basement membrane as revealed by ultra-high-resolution scanning electron microscopy.

    abstract::We examined the ultrastructure of the bovine glomerular basement membrane (GBM) and tubular basement membrane (TBM) using ultra-high-resolution scanning electron microscopy after conductive staining without metal coating. Purified basement membranes (BMs) were obtained by sonication and acellular BMs by detergent trea...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187800

    authors: Yamasaki Y,Makino H,Ota Z

    更新日期:1994-01-01 00:00:00

  • Porphyrins in renal transplantation.

    abstract::The porphyrin status of 38 renal transplant patients was investigated using a sensitive thin-layer chromatographic assay. Abnormalities of porphyrin synthesis observed in patients on hemodialysis were generally reversed on receipt of a transplant with sustained good renal function. Urinary coproporphyrin levels and th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182426

    authors: Day RS,Eales L

    更新日期:1982-01-01 00:00:00

  • Kidney disease and silicosis.

    abstract:AIM:To determine the prevalence of kidney disease in a cohort of individuals with silicosis. METHODS:Review of medical records and questionnaires from patients reported to a state surveillance system for silicosis. Reporting of individuals with silicosis is required by state law. All individuals with silicosis reporte...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045624

    authors: Rosenman KD,Moore-Fuller M,Reilly MJ

    更新日期:2000-05-01 00:00:00

  • Acute and chronic effects of captopril on bicyclo-PGEm, the stable bicyclic end product of prostaglandin E2 in essential hypertension.

    abstract::Hemodynamic and hormonal actions of acute (50 mg) and chronic (150 mg/day) captopril were tested in 10 patients with essential hypertension. Under short-term conditions blood pressure was reduced, heart rate and plasma adrenaline did not change, plasma angiotensin II and plasma aldosterone decreased. Plasma renin acti...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183910

    authors: Stanek B,Silberbauer K

    更新日期:1986-01-01 00:00:00

  • Effects of imidazole-2-hydroxibenzoate on glycosaminoglycan and albumin urinary excretion in type 1 diabetic patients.

    abstract::The effect of imidazole-2-hydroxibenzoate on urinary excretion rates of glycosaminoglycans and albumin in 22 insulin-dependent diabetics with albumin excretion rates under 300 mg/day was evaluated in a 165-day double blind crossover study. Unlike placebo, the drug reduced glycosaminoglycan and albumin excretion rates ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000185115

    authors: Baggio B,Briani G,Cicerello E,Gambaro G,Giorato C,Iori E,Lavagnini T,Crepaldi G

    更新日期:1988-01-01 00:00:00

  • Bradykinin induces a calcium-store- dependent calcium influx in mouse mesangial cells.

    abstract::Bradykinin (BK) elicits extracellular-dependent [Ca2+](i) elevations in mouse mesangial cells (MMC) that are not blocked by verapamil, nifedipine, L-nicardipine, NiCl(2), or LaCl(3). The aim of the present study was to evaluate the mechanisms involved in calcium influx induced by BK in MMC. [Ca2+](i) was analyzed thro...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000058409

    authors: Campos AH,Calixto JB,Schor N

    更新日期:2002-06-01 00:00:00

  • Changes in plasma atrial natriuretic factor during sequential fluid removal and biochemical correction in end-stage chronic renal failure patients.

    abstract::Plasma immunoreactive atrial natriuretic factor (ANF) levels, their chromatographic profiles (high-performance liquid chromatography; HPLC) and changes during sequential ultrafiltration (UF; 1 litre/h) and biochemical correction without fluid removal (BC; 3 h) were studied in 8 end-stage chronic renal failure patients...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000185919

    authors: Tonolo G,McMillan M,Richards AM,Montorsi P,Polonia J,Soro A,Troffa C,Glorioso N

    更新日期:1990-01-01 00:00:00

  • Circulating immune complexes during various forms of renal allograft rejection episodes.

    abstract::Previous reports on the nephritogenic and immunological enhancing capacity of posttransplant circulating immune complexes (CICs) are conflicting and have been confined to the study of acute rejection episode (AR). This study was undertaken to assess the nephritogenicity of CICs in patients undergoing accelerated acute...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182633

    authors: Jordan SC,Sakai R,Ettenger RB,Fine RN

    更新日期:1982-01-01 00:00:00

  • Immune response to Haemophilus influenzae type B vaccination in renal transplant recipients with well-functioning allografts.

    abstract:BACKGROUND:Haemophilus influenzae infection is a mild and self-limited disease in the healthy population. However, it may show an aggressive course in the immunocompromised state which underlines the importance of vaccination against this agent. On the other hand, posttranplant immunosuppression may impair immune respo...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000045246

    authors: Sever MS,Yildiz A,Eraksoy H,Badur S,Yüksel-Onel D,Görçin B,Türk S,Erkoç R

    更新日期:1999-01-01 00:00:00

  • Glycogen synthesis from serine in isolated perfused hindquarters of acutely uraemic rats.

    abstract::Isolated hindquarters of bilaterally nephrectomized and sham-operated rats were perfused in the presence and absence of 14C-labelled serine, respectively. After a perfusion period of 30 min 14C-serine was 4,074 +/- 270 dpm/ml in the perfusion medium of sham-operated animals and decreased to 2,800 +/- 190 dpm/ml in the...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183003

    authors: Djovkar A,Hörl WH,Heidland A

    更新日期:1983-01-01 00:00:00

  • Nephrocalcinosis in Amelogenesis Imperfecta Caused by the FAM20A Mutation.

    abstract:BACKGROUND/AIMS:Enamel-renal syndrome is characterized by nephrocalcinosis, enamel defects, gingival hyperplasia and eruption failures. It has been recently identified that recessive mutations in the FAM20A gene result in amelogenesis imperfecta (AI)-gingival fibromatosis. The aim of this research to determine whether ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000486607

    authors: Koruyucu M,Seymen F,Gencay G,Gencay K,Tuna EB,Shin TJ,Hyun HK,Kim YJ,Kim JW

    更新日期:2018-01-01 00:00:00

  • Peritoneal dialysis fluid inhibition of polymorphonuclear leukocyte respiratory burst activation is related to the lowering of intracellular pH.

    abstract::In order to elucidate the mechanism of peritoneal dialysis fluid inhibition of cell functions, laboratory-prepared fluids were used to investigate the specific influences of low pH and high lactate concentration on neutrophil viability, phagocytosis, respiratory burst activation and leukotriene B4 (LTB4) generation. I...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187485

    authors: Liberek T,Topley N,Jörres A,Petersen MM,Coles GA,Gahl GM,Williams JD

    更新日期:1993-01-01 00:00:00