Vascular Endothelial Growth Factor-A165b Restores Normal Glomerular Water Permeability in a Diphtheria-Toxin Mouse Model of Glomerular Injury.

abstract：:Cerebral salt-wasting syndrome (CSWS) has been regarded as a misnomer of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). We take the position that CSWS does exist and might be more common than SIADH. Differentiation between groups has been difficult because of overlapping signs, symptoms, and ...

journal_title：Nephron

authors： Maesaka JK,Gupta S,Fishbane S

更新日期：1999-06-01 00:00:00

abstract：:The possible role of altered renal prostaglandin metabolism in the generation of post-obstruction diuresis (POD) was examined in 16 adult male Sprague-Dawley rats. Inhibition of cyclooxygenase by the administration of a combination of two nonsteroidal anti-inflammatory drugs (NSAID), meclofenamate and indomethacin in ...

journal_title：Nephron

authors： Kauker ML,Zawada ET

更新日期：1992-01-01 00:00:00

abstract：:29 patients receiving haemodialysis treatment for chronic renal failure were divided into two groups on the basis of the presence or absence of bone disease as defined by radiology and bone alkaline phosphatase. The group of patient with bone disease showed a significantly greater increase in protein-bound calcium dur...

journal_title：Nephron

authors： Gosling P,Naik RB,Price CP,Sammons HG,Robinson BH

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND/AIMS:Glomerular basement membrane (GBM) thickening and mesangial matrix expansion are characteristic features of diabetic nephropathy. The present study investigates the role of endothelins (ETs) in the pathogenesis of such changes in diabetic nephropathy. METHODS:Diabetic (streptozotocin-induced, 65 mg/kg)...

journal_title：Nephron

authors： Chen S,Evans T,Deng D,Cukiernik M,Chakrabarti S

更新日期：2002-01-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and arginine vasopressin concentrations were measured in 9 patients with pregnancy-induced hypertension. The results were compared to those found in 7 normal pregnant women matched for age, duration of pregnancy, and parity. Plasma ANP levels were significantly higher in the pregnancy-...

journal_title：Nephron

authors： Elias AN,Vaziri ND,Pandian MR,Powers DR,Domurat E

更新日期：1988-01-01 00:00:00

abstract：:The effect of isotonic mannitol and saline in the early phase of mercuric chloride-(HgCl2-)induced acute renal failure (ARF) in the dog was evaluated. During the first 3 h after HgCl2 alone, glomerular filtration rate (GFR) fell from 1.94 +/- 0.14 to 1.04 +/- 0.11 and renal blood flow (RBF) from 13.99 +/- 1.18 to 7.28...

journal_title：Nephron

authors： Vanholder R,Leusen I,Lameire N

更新日期：1984-01-01 00:00:00

abstract：:A 37-year-old female presented with acute onset of glomerulonephritis 10 days following an upper respiratory infection. Serum complement components were depressed and proteinuria exceeded 3.0 g daily. Renal biopsy revealed granular staining of IgG and C3 along the basement membrane as well as small amounts of IgA in a...

journal_title：Nephron

authors： Yoshizawa N,McClung JA,Ohshima S,Takahashi K,Treser G

更新日期：1986-01-01 00:00:00

abstract：:A four-year-old male with steroid refractory nephrotic syndrome was found to have diffuse deposition of alpha 2-macroglobulin (alpha 2M) in the glomeruli which showed diffuse mesangial proliferation and partial hyalinization by light microscopy. Camostat mesylate, a commercially available synthetic proteinase inhibito...

journal_title：Nephron

authors： Asami T,Ohsawa S,Tomisawa S,Hashimoto K,Toyabe S,Sakai K

更新日期：1992-01-01 00:00:00

abstract：:We have previously documented the importance of tumor necrosis factor (TNF) alpha in the pathogenesis of nephrotoxic-serum nephritis in rats. In this study, we evaluated the possible relevance of the well-established cytocidal TNF activity to the mechanism of glomerular injury by assessing sensitivity of rat mesangial...

journal_title：Nephron

authors： Hruby ZW,Cybulsky AV,Lowry RP

更新日期：1990-01-01 00:00:00

abstract：:The role of T cell-mediated immunity in the early phase of nephrotoxic serum nephritis (NTN) was examined by transfer of pan T, CD8-positive, and CD4-positive cells. The disease was induced by transferring rabbit gamma-globulin (RGG)-sensitized T cells to nude (rnu/rnu) rats pretreated with a subnephritogenic dose (a ...

journal_title：Nephron

authors： Kuroda T,Kawasaki K,Oite T,Arakawa M,Shimizu F

更新日期：1994-01-01 00:00:00

abstract：:Platelet-activating factor (PAF) belongs to a new class of lipid chemical inflammatory mediators described as acetyl glyceryl ether phosphorylcholine. Although PAF has been implicated in kidney injury, its role in renal immune injury has not been clearly defined yet. We studied the levels of PAF in the plasma and urin...

journal_title：Nephron

authors： Iatrou C,Moustakas G,Antonopoulou S,Demopoulos CA,Ziroyiannis P

更新日期：1996-01-01 00:00:00

abstract：:The main regulatory hormone for the control of erythropoiesis is erythropoietin (EPO). This glycoprotein has a molecular weight of 34,000 daltons, about 40% of which is represented by carbohydrates. EPO leads to an enhanced mitosis and differentiation of erythroid precursors (colony-forming unit erythroid) in the bone...

journal_title：Nephron

authors： Bauer C,Kurtz A,Eckardt KU,Tannahill L

更新日期：1989-01-01 00:00:00

abstract：:Severe erythrocytosis is associated with increased whole blood viscosity and impaired blood flow. Since a reduced blood flow will cause tissue hypoxia and since tissue hypoxia is associated with increased synthesis of erythropoietin, erythrocytosis per se should cause an increase in the rate of red cell production. Th...

journal_title：Nephron

authors： Erslev AJ,Caro J,Besarab A

更新日期：1985-01-01 00:00:00

abstract：:Medullary sponge kidney was found in association with congenital absence of teeth (anodontia) in 3 siblings of a single family. Anodontia occurs in the rare familial syndrome of ectodermal dysplasia, but its association with a renal (mesodermal) anomaly is not known. The present report lends further support to a possi...

journal_title：Nephron

authors： Khoury Z,Brezis M,Mogle P

更新日期：1988-01-01 00:00:00

abstract：:Circumstantial evidence that pIgA has a key role in glomerular injury of IgAN is now strong. Although the answers to the questions posed in this review are necessarily incomplete, they do indicate that (1) pIgA is a major component of mesangial IgA. (2) circulating pIgA is increased and this pIgA is particularly enhan...

journal_title：Nephron

authors： Harper SJ,Feehally J

更新日期：1993-01-01 00:00:00

abstract：:We conducted a retrospective study with 750 peritoneal dialysis (PD) patients in a Spanish multicenter registry between 1993 and 1999 to analyze comorbidity and mortality in type 1 diabetes (T1D), type 2 diabetes (T2D) and nondiabetic (ND) patients. 163 patients (21.7%) were diabetic--96 T1D (58.8%) and 67 T2D (42.2%)...

journal_title：Nephron

authors： Miguel A,García-Ramón R,Pérez-Contreras J,Gómez-Roldán C,Alvariño J,Escobedo J,García H,Lanuza M,López-Menchero R,Olivares J,Tornero F,Albero D,Levante PD Multicenter group.

更新日期：2002-03-01 00:00:00

abstract：:4 patients on regular dialysis were studied by the echocardiographic method during ultrafiltration and dialysis performed sequentially according to two different protocols. Blood pressure, heart rate, cardiac output, stroke volume, systolic and diastolic dimension of the left ventricle, systolic and diastolic volumes ...

journal_title：Nephron

authors： Cini G,Camici M,Pentimone F,Palla R

更新日期：1982-01-01 00:00:00

abstract：:This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insuffic...

journal_title：Nephron

authors： Dunipace A,Brizendine E,Wilson M,Zhang W,Wilson C,Katz B,Kafrawy A,Stookey G

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIM:The ultrasonic transit time is currently the best method for measuring the blood flow rate in the extracorporeal hemodialysis circuit. The purpose of this study was to analyze the differences between blood flow as indicated by the hemodialysis blood roller pump (prescribed blood flow) and by an ultrasoni...

journal_title：Nephron

authors： Teruel JL,Fernández Lucas M,Marcén R,Rodríguez JR,López Sánchez J,Rivera M,Liaño F,Ortuño J

更新日期：2000-06-01 00:00:00

abstract：:The effects of dietary protein both before and after uranyl-nitrate-induced acute renal failure were investigated. Male Sprague-Dawley rats were maintained on high-protein (60%), normal-protein (20%), low-protein (5%) and no-protein diets for 8 days prior to intravenous administration of uranyl nitrate (10 mg/kg). Imm...

journal_title：Nephron

authors： Andrews PM,Bates SB

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Little is known about the effect of posttransplant opioid use on adherence to immunosuppressant therapy (IST) among adult renal transplant recipients (RTRs). OBJECTIVE:The aim of this study was to examine the relationship between opioid use and IST adherence among adult RTRs during the first year posttran...

journal_title：Nephron

authors： Chisholm-Burns MA,Spivey CA,Potukuchi PK,Streja E,Kalantar-Zadeh K,Kovesdy CP,Molnar MZ

更新日期：2020-01-01 00:00:00

abstract：:Tubular necrosis elicits a process of renal tissue repair characterized by an increase of cell turnover in tubular epithelium. The present study was undertaken to examine the distribution of epidermal growth factor (EGF) and/or of its larger precursor proEGF in the kidney undergoing tubular regeneration. Sprague-Dawle...

journal_title：Nephron

authors： Nonclercq D,Toubeau G,Lambricht P,Heuson-Stiennon JA,Laurent G

更新日期：1991-01-01 00:00:00

abstract：:This study aims to raise the possibility of methylguanidine, a peroxidative product of creatinine, as a measure of the peroxidative state. As a known standard, we measured the inhibitory effect of uremic serum on the NADPH-dependent microsomal lipid peroxidation. This is an established method for evaluating the peroxi...

journal_title：Nephron

authors： Nagase S,Aoyagi K,Hirayama A,Gotoh M,Ueda A,Tomida C,Kikuchi H,Takemura K,Koyama A

更新日期：1996-01-01 00:00:00

abstract：:To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in pla...

journal_title：Nephron

authors： Niwa T,Fujishiro T,Uema K,Tsuzuki T,Tominaga Y,Emoto Y,Miyazaki T,Maeda K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Experimental evidence suggests that hyperosmolality may be a causative factor in the development of both salt-sensitive hypertension and chronic kidney disease (CKD). There are no population-wide studies in young persons to assess the relationships among these factors. OBJECTIVE:To determine the association...

journal_title：Nephron

authors： Chmielewski J,Khalsa DD,Carmody JB

更新日期：2019-01-01 00:00:00

abstract：:Increasing urinary net acid (titratable acid + NH4 - HCO-3) excretion is accompanied by an increased urinary Ca excretion because of reduced renal tubular reabsorption of filtered Ca. The relationships between urinary Ca excretion rates and urinary net acid excretion rates are reviewed for data: (1) among healthy adul...

journal_title：Nephron

authors： Lemann J Jr

更新日期：1999-01-01 00:00:00

abstract：:To avoid the use of aluminium as a phosphate binder, patients on CAPD who were stable were dialysed against a peritoneal dialysis fluid which was magnesium free. A mixture of calcium and magnesium carbonate was used as a phosphate binder over a period in excess of 1 year. Vitamin D analogues were used in the majority....

journal_title：Nephron

authors： Parsons V,Baldwin D,Moniz C,Marsden J,Ball E,Rifkin I

更新日期：1993-01-01 00:00:00

abstract：:The porphyrin status of 38 renal transplant patients was investigated using a sensitive thin-layer chromatographic assay. Abnormalities of porphyrin synthesis observed in patients on hemodialysis were generally reversed on receipt of a transplant with sustained good renal function. Urinary coproporphyrin levels and th...

journal_title：Nephron

authors： Day RS,Eales L

更新日期：1982-01-01 00:00:00

abstract：:The glomerular mesangium is an important site of activity in patients with heroin addiction. We studied the effect of morphine, a metabolite of heroin, on the mesangial immunoglobulin G aggregate uptake in a model of specific mesangial cell injury. Isolated specific mesangial cell injury was developed in Lewis rats by...

journal_title：Nephron

authors： Singhal PC,Pan CQ,Sagar S,Valderrama E,Stahl RA

更新日期：1996-01-01 00:00:00

abstract：:A low-protein, low-phosphorus diet supplemented with essential amino acids and keto analogues was given to 12 rats, starting from the 90th day after subtotal nephrectomy. The purpose was to assess its effect on the residual renal function and on the nutritional status in rats with already established severe renal fail...

journal_title：Nephron

authors： Barsotti G,Moriconi L,Cupisti A,Dani L,Ciardella F,Lupetti S,Giovannetti S

更新日期：1988-01-01 00:00:00