Insulin and the kidney.

abstract：:Gastrointestinal infection with verotoxin-producing Escherichia coli (VTEC) has been strongly implicated in the etiology of the hemolytic uremic syndrome (HUS), the leading cause of pediatric acute renal failure. The binding of fluorescein-conjugated VT1 overlaid on to frozen human renal sections has been examined. Se...

journal_title：Nephron

authors： Lingwood CA

更新日期：1994-01-01 00:00:00

abstract：:The concentration changes, during hemodialysis treatment, of 18 characteristic uremia compounds, analyzed by high-pressure liquid chromatography in sera of renal patients were studied. Pre- to postdialysis concentration ratios (dialysis ratio, D) varied from 0.83 to 3.04 for the different solutes. A division into thre...

journal_title：Nephron

authors： Schoots AC,Peeters JA,Gerlag PG

更新日期：1989-01-01 00:00:00

abstract：:25 patients undergoing regular haemodialysis for chronic renal failure underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the intermediate period of everyday activity at home. A low dialysate potassium concentration (1.7 mEq/l) was used. Clinically significant arrhythmias (greater th...

journal_title：Nephron

authors： Kyriakidis M,Voudiclaris S,Kremastinos D,Robinson-Kyriakidis C,Vyssoulis G,Zervakis D,Toutouzas P,Komninos Z,Avgoustakis D

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Scientists use preclinical models of acute kidney injury (AKI) to decipher mechanisms and develop therapy, but translation of therapies to patients remains poor. Models that better resemble patients, including those within clinical care, should be considered. SUMMARY:Mice provide many advantages to the stud...

journal_title：Nephron

authors： Billings FT 4th

更新日期：2019-01-01 00:00:00

abstract：:The study aimed to evaluate the behavior of alpha-glutathione S-transferase (alpha-GST) in the serum of hemodialysis patients with hepatitis C virus (HCV) infection following treatment with high-dose IFN-alpha-2b. Ten patients with detected anti-HCV antibodies and HCV RNA by RT-PCR were selected and treated with high-...

journal_title：Nephron

authors： Boran M,Cetin S

更新日期：1999-01-01 00:00:00

abstract：:8 patients who developed proteinuria whilst receiving penicillamine for rheumatoid arthritis have been studied. Light microscopy of renal biopsy specimens showed evidence of an extramembranous nephropathy in 6 cases, with epimembranous spikes infrequently described previously in association with penicillamine. ...

journal_title：Nephron

authors： Ross JH,McGinty F,Brewer DG

更新日期：1980-01-01 00:00:00

abstract：:Ischemic renal failure was produced in rabbits by occluding the renal arteries for 90 min. Group 1 (n = 8) received radiocontrast media at the time of occlusion, group 2 (n = 8) 24 h after occlusion, and group 3 (n = 8) 3 days after occlusion. Group 4 (n = 12) was subjected to ischemic injury alone, group 5 (n = 4) se...

journal_title：Nephron

authors： Schultz SG,Lavelle KJ,Swain R

更新日期：1982-01-01 00:00:00

abstract：:The purpose of this study was to characterize renal cell carcinoma tissue by the measurement of microacoustic properties. A scanning acoustic microscope system operating in the frequency range of 100-200 MHz was employed and the attenuation constant and sound speed were measured on the two-dimensional distribution. Th...

journal_title：Nephron

authors： Sasaki H,Tanaka M,Saijo Y,Okawai H,Terasawa Y,Nitta S,Suzuki K

更新日期：1996-01-01 00:00:00

abstract：:Oral phosphatidylcholine at 900 mg/day was given to 4 patients with high lymph absorption for 8 weeks. Fluid and solute transfer before and after treatment were compared to 4 similar controls given placebo. None of the patients had overt ultrafiltration problems. After treatment, overnight peritoneal effluent phosphol...

journal_title：Nephron

authors： Chan PC,Tam SC,Robinson JD,Yu L,Ip MS,Chan CY,Cheng IK

更新日期：1991-01-01 00:00:00

abstract：:A 2-year prospective study was done in 45 patients to see whether the FENa test, done at first nephrology consultation visit for acute renal failure, was useful in prognosticating whether patients would recover renal function spontaneously or need dialysis. Of 26 patients who recovered renal function spontaneously, 8 ...

journal_title：Nephron

authors： Pru C,Kjellstrand CM

更新日期：1984-01-01 00:00:00

abstract：:A 58-year-old woman who suffered from a heterozygous Fabry's disease and immune complex crescentic glomerulonephritis (GN) is reviewed. The diagnosis was made on the basis of the pathologic findings and peripheral leukocyte alpha-galactosidase activity. Light microscopy revealed a vacuolization of epithelial cells and...

journal_title：Nephron

authors： Shimazu K,Tomiyoshi Y,Aoki S,Sakemi T,Sugihara H

更新日期：2002-10-01 00:00:00

abstract：:Fifteen patients with advanced renal failure (creatinine clearance less than 25 ml/mn) and with severe albuminuria (greater than 1.5 g/24 h) were put on a low-protein (0.3 g/kg body weight), low-phosphorus (5-7 mg/kg body weight) diet supplemented with essential amino acids and ketoanalogues. During the 6-month follow...

journal_title：Nephron

authors： Aparicio M,Bouchet JL,Gin H,Potaux L,Morel D,de Precigout V,Lifermann F,Gonzalez R

更新日期：1988-01-01 00:00:00

abstract：:We measured levels of platelet-derived microparticles (PMP), which have coagulative activity and are produced by platelet activation or physical stimulation, and CD62P/CD63-positive platelets in patients with diabetes mellitus to determine their clinical significance and effects on complications of diabetes including ...

journal_title：Nephron

authors： Omoto S,Nomura S,Shouzu A,Hayakawa T,Shimizu H,Miyake Y,Yonemoto T,Nishikawa M,Fukuhara S,Inada M

更新日期：1999-01-01 00:00:00

abstract：:The main regulatory hormone for the control of erythropoiesis is erythropoietin (EPO). This glycoprotein has a molecular weight of 34,000 daltons, about 40% of which is represented by carbohydrates. EPO leads to an enhanced mitosis and differentiation of erythroid precursors (colony-forming unit erythroid) in the bone...

journal_title：Nephron

authors： Bauer C,Kurtz A,Eckardt KU,Tannahill L

更新日期：1989-01-01 00:00:00

abstract：AIMS AND METHODS:This study was carried out to clarify whether the urinary excretion of type IV collagen (u-IV collagen) detected by specific radioimmunoassay, can be used as an indicator for the progression of diabetic nephropathy. RESULTS:u-IV collagen was higher in diabetic subjects with microalbuminuria and overt ...

journal_title：Nephron

authors： Watanabe H,Sanada H,Shigetomi S,Katoh T,Watanabe T

更新日期：2000-09-01 00:00:00

abstract：:Radial arterial spasm in uremic patients undergoing construction of internal arteriovenous (AV) dialysis fistulas was investigated transcutaneously using ultrasonic Doppler flowmetry. In 5 of 15 patients, radial arterial blood flow was significantly decreased 5 min after anastomosing the radial cephalic vein with the ...

journal_title：Nephron

authors： Owada A,Saito H,Mochizuki T,Tanaka M,Otsuka M,Yokoyama Y,Fukuda S

更新日期：1993-01-01 00:00:00

abstract：:A 45-year-old male was admitted to the hospital because of polyuria and polydipsia. After admission, proteinuria and hematuria were found. The kidney function deteriorated and necessitated the initiation of chronic hemodialysis. Examination of the bone marrow revealed multiple myeloma and kappa light chains were found...

journal_title：Nephron

authors： Knobler H,Kopolovic J,Kleinman Y,Rubinger D,Silver J,Friedlaender MM,Popovtzer MM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...

journal_title：Nephron

authors： Shikano M,Sobajima H,Yoshikawa H,Toba T,Kushimoto H,Katsumata H,Tomita M,Kawashima S

更新日期：2000-05-01 00:00:00

abstract：:A 62-year-old woman gave clinical manifestation of liver cirrhosis. Urinary protein was false positive, no uremia was found and renal changes were entirely overlooked. Deposition of abundant lipids (globoside and ceramide trihexoside) was found in the kidneys; essentially degenerative changes of the tubular epithelia ...

journal_title：Nephron

authors： Miyasaki K

更新日期：1975-01-01 00:00:00

abstract：:Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, ...

journal_title：Nephron

authors： Perico L,Benigni A,Remuzzi G

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic i...

journal_title：Nephron

authors： DeWolf SE,Shigeoka AA,Scheinok A,Kasimsetty SG,Welch AK,McKay DB

更新日期：2017-01-01 00:00:00

abstract：:The sera of 64 patients with extracapillary glomerulonephritis were investigated by enzyme-linked immunosorbent assay for the presence of antibody to human neutrophil myeloperoxidase (MPO). In all, circulating anti-MPO were found in 30% and antineutrophil cytoplasm antibodies (ANCA) detected by indirect immunofluoresc...

journal_title：Nephron

authors： Nässberger L,Sjöholm AG,Thysell H

更新日期：1990-01-01 00:00:00

abstract：:Renal nerves were stimulated either directly (loop electrodes) or indirectly (bilateral carotid occlusion with maintenance of control blood pressure) in anesthetized dogs to determine the effects on renal blood flow (RBF), glomerular filtration rate (GFR), sodium excretion (UNaV), and intrarenal distribution of blood ...

journal_title：Nephron

authors： Katz MA,Shear L

更新日期：1975-01-01 00:00:00

abstract：:The effect of isotonic mannitol and saline in the early phase of mercuric chloride-(HgCl2-)induced acute renal failure (ARF) in the dog was evaluated. During the first 3 h after HgCl2 alone, glomerular filtration rate (GFR) fell from 1.94 +/- 0.14 to 1.04 +/- 0.11 and renal blood flow (RBF) from 13.99 +/- 1.18 to 7.28...

journal_title：Nephron

authors： Vanholder R,Leusen I,Lameire N

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The prevalence of subclinical atherosclerosis and the main predictors of progression of this condition in patients undergoing peritoneal dialysis (PD) have been insufficiently investigated. OBJECTIVES AND METHOD:Following a prospective, multicenter, observational design, we studied 237 patients who were tre...

journal_title：Nephron

authors： Pérez Fontán M,Borràs Sans M,Bajo Rubio MA,Rodriguez-Carmona A,Betriu A,Valdivielso JM,Fernández E,NEFRONA Study investigators.

更新日期：2017-01-01 00:00:00

abstract：:Nonspecific symptoms are common in dialysis patients but few methods are available to measure their severity and their response to alteration in dialysis therapy. To determine the clinical features and measure the severity of the most important symptoms in end-stage renal disease (ESRD) patients, 97 dialysis patients ...

journal_title：Nephron

authors： Parfrey PS,Vavasour HM,Henry S,Bullock M,Gault MH

更新日期：1988-01-01 00:00:00

abstract：:Serum leptin concentrations in normal humans have been reported to correlate with the body mass index (BMI) as well as with the body fat mass. In this study, we measured serum leptin concentrations in 107 patients on hemodialysis, 30 of whom had diabetes mellitus as the cause, and examined the clinical significance. F...

journal_title：Nephron

authors： Nakazono H,Nagake Y,Ichikawa H,Makino H

更新日期：1998-09-01 00:00:00

abstract：:Increased free-radical production leading to oxidative stress may contribute to the development of cardiovascular complications in haemodialysis patients. The ferroxidase activity of caeruloplasmin forms an important component of antioxidant defences in body fluids. The aim of this study was to assess ferroxidase acti...

journal_title：Nephron

authors： Roxborough HE,Mercer C,McMaster D,Maxwell AP,Young IS

更新日期：2000-03-01 00:00:00

abstract：:An unusual case of progressive systemic sclerosis with rapidly progressing renal failure after a successful delivery is described. The presenting syndrome was malignant hypertension. The blood pressure was refractory to the various therapeutic measures which were instituted, including hemodialysis. The patient, theref...

journal_title：Nephron

authors： Ehrenfeld M,Licht A,Stessman J,Yanko L,Rosenmann E

更新日期：1977-01-01 00:00:00

abstract：:We determined the clinical and immunopathological effects of dilazep hydrochloride (dilazep) on IgA nephropathy of ddY mice. Group I (early-treatment group, n = 10) was orally treated with 300 mg/kg body weight of this drug from 12 weeks of age until 60 weeks of age, and group II (late-treatment group, n = 10) was als...

journal_title：Nephron

authors： Hayashi T,Kaneko S,Thang NT,Shou I,Shirato I,Tomino Y

更新日期：2000-11-01 00:00:00