Abstract:
:We determined the clinical and immunopathological effects of dilazep hydrochloride (dilazep) on IgA nephropathy of ddY mice. Group I (early-treatment group, n = 10) was orally treated with 300 mg/kg body weight of this drug from 12 weeks of age until 60 weeks of age, and group II (late-treatment group, n = 10) was also treated with the same dosage of this drug from 20 weeks of age until 60 weeks of age. Group III (control group, n = 10) received drinking water. On immunofluorescence, distribution and intensity of IgA and C3 depositions in glomeruli of group I and group II animals were significantly decreased as compared with those in group III. The expression of fibronectin, laminin, or type IV collagen in glomeruli was basically similar in the three groups treated with or without dilazep. On light microscopy, the expansion of glomerular mesangial areas and the average number of intraglomerular cells were markedly decreased as compared with those in group III. The levels of urinary protein excretion in groups I and II were significantly lower than those in group III (p < 0.01 and p < 0.05). These findings suggest that treatment with dilazep might improve the clinical and immunopathological findings in IgA nephropathy of ddY mice.
journal_name
Nephronjournal_title
Nephronauthors
Hayashi T,Kaneko S,Thang NT,Shou I,Shirato I,Tomino Ydoi
10.1159/000045788subject
Has Abstractpub_date
2000-11-01 00:00:00pages
327-32issue
3eissn
1660-8151issn
2235-3186pii
45788journal_volume
86pub_type
杂志文章相关文献
NEPHRON文献大全abstract::In the present study, activity of polymorphonuclear leukocyte (PMNL) intracellular antioxidant enzymes, i.e. catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX), was assessed in CRF patients on hemodialysis (HD), or continuous ambulatory peritoneal dialysis (CAPD) and in healthy controls. The activit...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188708
更新日期:1995-01-01 00:00:00
abstract::The number of mast cells in the skin was evaluated in 25 patients with end-stage renal failure on different treatment modality (conservative, hemodialysis and peritoneal dialysis). According to the presence of pruritus, uremic patients were divided into two groups: group A, 13 patients with diffuse pruritus, and group...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186826
更新日期:1992-01-01 00:00:00
abstract::A 5-year-old Chinese girl had had absence seizures and received sodium valproate (VPA) treatment which provided good control. Six months later, she developed interstitial nephritis with proteinuria and microhematuria. Renal biopsy revealed interstitial nephritis with granular deposition of immunoglobulin G (IgG) and C...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184867
更新日期:1988-01-01 00:00:00
abstract::Serum ferritin level has been shown by many investigators to be a good indicator of bone marrow iron stores in normal subjects. Although this correlation may hold in some pathological situations, it is lost in others. In leukemia a dissociation has been observed between serum ferritin levels and bone marrow iron store...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186241
更新日期:1991-01-01 00:00:00
abstract::8 patients who developed proteinuria whilst receiving penicillamine for rheumatoid arthritis have been studied. Light microscopy of renal biopsy specimens showed evidence of an extramembranous nephropathy in 6 cases, with epimembranous spikes infrequently described previously in association with penicillamine. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181984
更新日期:1980-01-01 00:00:00
abstract::Tissue fluid and plasma oncotic pressure levels were measured in an unselected group of 13 patients presenting with congestive heart failure. Patients had a mean serum albumin of 3.6 g/dl +/- (SD) 0.35; serum oncotic pressure was 22.23 +/- 1.8 mm Hg; tissue fluid (lower leg) oncotic pressure was 0.985 +/- 0.34 mm Hg. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185804
更新日期:1990-01-01 00:00:00
abstract::Human immunodeficiency virus (HIV) infection has been associated with several renal disorders. Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) were also described in several patients with overt AIDS. We describe a patient who presented with HUS and only subsequent investigation to find the caus...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000188916
更新日期:1996-01-01 00:00:00
abstract::In order to elucidate the mechanism of peritoneal dialysis fluid inhibition of cell functions, laboratory-prepared fluids were used to investigate the specific influences of low pH and high lactate concentration on neutrophil viability, phagocytosis, respiratory burst activation and leukotriene B4 (LTB4) generation. I...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187485
更新日期:1993-01-01 00:00:00
abstract::The biochemistry and function of vanadate and its possible role in health as well as in disease remains one of the most fascinating stories in biology. This review has surveyed the pertinent literature regarding its effect in the normal kidney and other tissues. While inhibition of the Na(+)-K+ ATPase enzyme was the f...
journal_title:Nephron
pub_type: 社论,评审
doi:10.1159/000187913
更新日期:1994-01-01 00:00:00
abstract::Most hypertensive subjects are overweight, and as a consequence have an increased prevalence of hypercholesterolaemia, impaired glucose tolerance, and left ventricular hypertrophy. Reduction of the blood pressure by antihypertensive drugs without control of the obesity leaves these additional risk factors for cardiova...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184543
更新日期:1987-01-01 00:00:00
abstract::Renin substrate concentrations and the release of renin in response to the rapid removal of 15 ml/kg weight blood or subcutaneous administration of 500 microgram/kg body weight isoproterenol were measured in control rats and animals recovering from prior myohemoglobinuric acute renal failure (recovery rats). Blood for...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181429
更新日期:1978-01-01 00:00:00
abstract::We describe a case of nephrotic syndrome (idiopathic membranous glomerulonephropathy) with high serum HDL cholesterol (91 mg/100 ml) which increased to 240 mg/100 ml following steroid therapy. The increase in HDL was mainly a result of increased HDL2 and increased plasma apolipoprotein A-I. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183556
更新日期:1985-01-01 00:00:00
abstract::Medullary sponge kidney was found in association with congenital absence of teeth (anodontia) in 3 siblings of a single family. Anodontia occurs in the rare familial syndrome of ectodermal dysplasia, but its association with a renal (mesodermal) anomaly is not known. The present report lends further support to a possi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184918
更新日期:1988-01-01 00:00:00
abstract::Clearance and in vitro microperfusion studies were performed in rabbits to determine the effect of cisplatin on proximal straight tubule transport of calcium and magnesium. Rabbits were injected with cisplatin (2.5 mg/kg i.p. once weekly) for 3 weeks, whereas control rabbits received normal saline solution which serve...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184988
更新日期:1988-01-01 00:00:00
abstract::Recent studies have revealed the potential importance of the extracellular matrix (ECM) in the modulation of mesangial cell (MC) function. Interleukin-6 (IL-6) is produced by MCs and was shown to induce MC proliferation, acting as an autocrine growth factor. Heparin is a known inhibitor of MC proliferation. It was sho...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000190276
更新日期:1997-01-01 00:00:00
abstract::The accumulation in blood plasma and efficiency of hemodialysis of pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronic renal failure (CRF) was investigated. As a reference, the analysis of the above metabolites in the plasma of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187313
更新日期:1993-01-01 00:00:00
abstract::Conjugated diene fatty acids (CDFA) were evaluated by second derivative spectrophotometry in the plasma and adipose tissue of 42 chronic renal failure (CFR) patients in conservative treatment, 40 patients treated by hemodialysis (HD) with cuprophane, cellulose acetate or hemophan, 29 treated by hemodiafiltration (HDF)...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187520
更新日期:1993-01-01 00:00:00
abstract::Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046001
更新日期:2001-07-01 00:00:00
abstract::We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreas...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187835
更新日期:1994-01-01 00:00:00
abstract::During hemodialysis therapy, a large amount of water is removed from the patient's blood in a short time; however, blood pressure remains stable in most patients. As water is removed, the circulating serum proteins become more concentrated, resulting in a marked increase in the driving force which pulls water from the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189320
更新日期:1996-01-01 00:00:00
abstract::Cerebral salt-wasting syndrome (CSWS) has been regarded as a misnomer of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). We take the position that CSWS does exist and might be more common than SIADH. Differentiation between groups has been difficult because of overlapping signs, symptoms, and ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000045384
更新日期:1999-06-01 00:00:00
abstract::Increasing urinary net acid (titratable acid + NH4 - HCO-3) excretion is accompanied by an increased urinary Ca excretion because of reduced renal tubular reabsorption of filtered Ca. The relationships between urinary Ca excretion rates and urinary net acid excretion rates are reviewed for data: (1) among healthy adul...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000046294
更新日期:1999-01-01 00:00:00
abstract::Platelet activation is commonly monitored with a battery of monoclonal antibodies against different platelet epitopes with controversial results. The transient expression of platelet markers and their role mediating interactions with other cells could easily explain these discrepancies. The present study has evaluated...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045167
更新日期:1998-10-01 00:00:00
abstract::A case of inferior vena caval compression by hepatic cysts as a complication of adult polycystic kidney disease is presented and its management is discussed. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185816
更新日期:1990-01-01 00:00:00
abstract::We studied the expression of Mac-1 on granulocytes (flow cytometry) from 9 patients (27 examinations) during hemodialysis with cuprophane membranes (CuM). Samples were drawn before dialysis and from the arterial and venous lines at 5, 15 and 180 min. Granulocytopenia was most pronounced after 15 min of treatment. Mac-...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186865
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Experimental evidence suggests that hyperosmolality may be a causative factor in the development of both salt-sensitive hypertension and chronic kidney disease (CKD). There are no population-wide studies in young persons to assess the relationships among these factors. OBJECTIVE:To determine the association...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000497780
更新日期:2019-01-01 00:00:00
abstract::The feasibility of room temperature incubation of Microstix-3 specimens to detect urinary tract infection was studied. This procedure, if successful, would allow home monitoring of patients and eliminate the need for an incubator. Four Microstix-3 strips were dipped into each of 1,241 urine specimens and incubated at ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182640
更新日期:1982-01-01 00:00:00
abstract::The investigation of a sample of 99 women on maintenance hemodialysis has shown the presence of sexual disturbances to a great extent: the rate of sexual intercourse and the ability to reach orgasm were significantly lower than in age-matched control women. 80% declared a reduction in their sexual desire and the frequ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183243
更新日期:1984-01-01 00:00:00
abstract::Two observers, unaware of each other's findings and of the diagnosis, examined red cells in the urine of 109 patients by phase-contrast microscopy. All specimens were examined uncentrifuged by inverted microscopy, and 48 of the 109 were also examined under a light microscope after centrifugation. We were unable to con...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000184011
更新日期:1986-01-01 00:00:00
abstract::The clinical profile of a patient with a 15 years' evolution of acne conglobata developing systemic amyloidosis with severe renal involvement is described, and the possible influence of suppurative skin foci surgical excision on the rapid progression to terminal renal failure is discussed. This etiological cause of se...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186227
更新日期:1991-01-01 00:00:00