Abstract:
:During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7-1.2 mg/100 ml, BUN 53-89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but not significant increase in skin calcium was found. However, a significant decrease in cardiac calcium was found for the uremic animals. Total body calcium as determined by neutron activation analysis was significantly lower in the uremic rat when compared with the age-matched animal. However, when normalized for body weight, the total calcium content in uremic rats did not differ from the controls. Similar findings were observed for the absolute calcium content of the tibia and when normalized for weight. Furthermore, a highly significant linear relationship (r = 0.92, p less than 0.001) was established between absolute levels of total body calcium and tibia calcium which was identical for control and uremic groups.
journal_name
Nephronjournal_title
Nephronauthors
Ellis KJ,Martino A,Yasumura S,Brook D,Cohn SH,Letteri JMdoi
10.1159/000180786subject
Has Abstractpub_date
1977-01-01 00:00:00pages
124-31issue
2eissn
1660-8151issn
2235-3186journal_volume
18pub_type
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