Distribution of calcium in the rat due to chronic renal failure.

Abstract:

:During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7-1.2 mg/100 ml, BUN 53-89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but not significant increase in skin calcium was found. However, a significant decrease in cardiac calcium was found for the uremic animals. Total body calcium as determined by neutron activation analysis was significantly lower in the uremic rat when compared with the age-matched animal. However, when normalized for body weight, the total calcium content in uremic rats did not differ from the controls. Similar findings were observed for the absolute calcium content of the tibia and when normalized for weight. Furthermore, a highly significant linear relationship (r = 0.92, p less than 0.001) was established between absolute levels of total body calcium and tibia calcium which was identical for control and uremic groups.

journal_name

Nephron

journal_title

Nephron

authors

Ellis KJ,Martino A,Yasumura S,Brook D,Cohn SH,Letteri JM

doi

10.1159/000180786

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

124-31

issue

2

eissn

1660-8151

issn

2235-3186

journal_volume

18

pub_type

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