Abstract:
:In pharmacologic doses E series prostaglandins attenuate the development of immune complex nephritis. We studied the effect of the dietary prostaglandin precursor linoleic acid on murine apoferritin-induced immune complex glomerulonephritis. High, normal, or low linoleic acid diets were fed to mice for 4 weeks prior to and during the intraperitoneal apoferritin administration. A high linoleic acid diet feeding was associated with less proteinuria, less renal histologic damage, and prevented a rise in serum creatinine. We conclude that linoleic acid has a protective effect on the development of murine apoferritin-induced immune complex nephritis.
journal_name
Nephronjournal_title
Nephronauthors
Kher V,Barcelli U,Weiss M,Pollak VEdoi
10.1159/000183382subject
Has Abstractpub_date
1985-01-01 00:00:00pages
261-6issue
3eissn
1660-8151issn
2235-3186journal_volume
39pub_type
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