Effects of dietary linoleic acid enrichment on induction of immune complex nephritis in mice.

Abstract:

:In pharmacologic doses E series prostaglandins attenuate the development of immune complex nephritis. We studied the effect of the dietary prostaglandin precursor linoleic acid on murine apoferritin-induced immune complex glomerulonephritis. High, normal, or low linoleic acid diets were fed to mice for 4 weeks prior to and during the intraperitoneal apoferritin administration. A high linoleic acid diet feeding was associated with less proteinuria, less renal histologic damage, and prevented a rise in serum creatinine. We conclude that linoleic acid has a protective effect on the development of murine apoferritin-induced immune complex nephritis.

journal_name

Nephron

journal_title

Nephron

authors

Kher V,Barcelli U,Weiss M,Pollak VE

doi

10.1159/000183382

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

261-6

issue

3

eissn

1660-8151

issn

2235-3186

journal_volume

39

pub_type

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