Mesangial deposition of J chain-linked polymeric IgA in IgA nephropathy.

abstract：:Rat sera, 10-30 h after unilateral nephrectomy (UNI), enhance 3H-thymidine ("3H-Tdr) incorporation into DNA of incubating renal tissue from control rats. Stimulation is even greater when extracts from remaining growing kidneys 20 h after UNI are combined with sera from rats after UNI. UNI extracts, i.e., extracts from...

journal_title：Nephron

authors： Castillo O,Robertson D,Goldin H,Preuss HG

更新日期：1980-01-01 00:00:00

abstract：:Kidney biopsy remains the gold standard for uncovering the pathogenesis of acute and chronic kidney diseases. However, the ability to perform high resolution, quantitative, molecular and cellular interrogation of this precious tissue is still at a developing stage compared to other fields such as oncology. Here, we di...

journal_title：Nephron

authors： Winfree S,Dagher PC,Dunn KW,Eadon MT,Ferkowicz M,Barwinska D,Kelly KJ,Sutton TA,El-Achkar TM

更新日期：2018-01-01 00:00:00

abstract：:Effect of the immunosuppressive agent, ciclosporin (CS), on bovine serum albumin (BSA) nephritis in rats was evaluated. Eight weeks after immunization, 19 male Wistar rats received a daily intravenous dose of BSA (2 mg). Two weeks later, 11 rats received BSA and an oral dose of CS (10 mg/kg), and 8 rats received only ...

journal_title：Nephron

authors： Fujita M,Iida H,Asaka M,Izumino K,Takata M,Sasayama S

更新日期：1991-01-01 00:00:00

abstract：:5 cases of severe acute renal failure caused by ethyl alcohol-induced rhabdomyolysis are reviewed. 4 patients were dialyzed. All patients recovered completely from the renal failure. ...

journal_title：Nephron

authors： Haapanen E,Pellinen TJ,Partanen J

更新日期：1984-01-01 00:00:00

abstract：:To evaluate the patterns of renal images and the diagnostic value as a screening test of the whole-body bone and renal scintigraphy with technetium-99m-methylene diphosphonate (99mTc-MDP) or -pyrophosphate (99mTc-PYP), we performed bone scintigraphy in 6 patients with acute renal failure (ARF) with severe loin pain an...

journal_title：Nephron

authors： Han JS,Kim YG,Kim S,Lee MC,Lee JS,Kim SH

更新日期：1991-01-01 00:00:00

abstract：:Collagenolytic activity of rat kidneys with streptozotocin diabetes was estimated by means of a biological collagenase assay and compared to healthy controls. Collagenolytic activity was found significantly decreased in rat kidneys with diabetes correlating with blood glucose levels (r = -0.82, p less than 0.001). Ele...

journal_title：Nephron

authors： Lubec G,Leban J,Peyroux J,Sternberg M,Pollak A,Latzka U,Coradello H

更新日期：1982-01-01 00:00:00

abstract：:Animal models are essential tools to understand the mechanisms underlying the development and progression of renal disease and to study potential therapeutic approaches. Recently, interventional models suitable to induce acute and chronic kidney disease in the mouse have become a focus of interest due to the wide avai...

journal_title：Nephron

authors： Rabe M,Schaefer F

更新日期：2016-01-01 00:00:00

abstract：:Survival after serum creatinine exceeded 10.0 mg/100 ml was increased if one peritoneal dialysis was performed. After one peritoneal dialysis 'survival' of 62 patients to the present time, death or the next dialysis averaged 119 days; median survival was 28 days. Characteristics of prolonged survivors were persisten...

journal_title：Nephron

authors： Maher JF,Ahearn DJ,Bryan CW,Nolph KD

更新日期：1975-01-01 00:00:00

abstract：:Hemodialysis (HD) prescription is usually based on the periodical measurement of the Kt/V achieved in a midweek dialysis session. The purpose of the study was to assess the duration of each HD session to achieve a target dose of dialysis. This allowed to determine whether a given dialysis session may be considered rep...

journal_title：Nephron

authors： Hernandez-Herrera G,Martin-Malo A,Rodriguez M,Aljama P

更新日期：2001-09-01 00:00:00

abstract：:In order to elucidate the mechanism of peritoneal dialysis fluid inhibition of cell functions, laboratory-prepared fluids were used to investigate the specific influences of low pH and high lactate concentration on neutrophil viability, phagocytosis, respiratory burst activation and leukotriene B4 (LTB4) generation. I...

journal_title：Nephron

authors： Liberek T,Topley N,Jörres A,Petersen MM,Coles GA,Gahl GM,Williams JD

更新日期：1993-01-01 00:00:00

abstract：:The Spanish brush goat (Capra hiricus) was studied as an animal model for the anephric state. This rugged animal has a hardy appetite and offers ready blood access for dialysis and sampling. BUN, plasma creatinine and potassium could be brought to normal values by daily hemodialysis. Continual weight loss, severe anem...

journal_title：Nephron

authors： Bower JD,Holbert RD,Pearson JE,Jones Q,Bengis R,Berndt WO

更新日期：1980-01-01 00:00:00

abstract：:It has been generally accepted that acidosis results in hyperkalemia because of shifts of potassium from the intracellular to the extracellular compartment. There is ample clinical and experimental evidence, however, to support the conclusion that uncomplicated organic acidemias do not produce hyperkalemia. In acidosi...

journal_title：Nephron

authors： Perez GO,Oster JR,Vaamonde CA

更新日期：1981-01-01 00:00:00

abstract：CONTEXT:The widespread use of diuretics, potassium supplements, and medications that block renin angiotensin system puts the chronic kidney disease (CKD) population at high risk for dyskalemia, both hyperkalemia and hypokalemia. The optimal potassium level in a CKD patient is unknown. Subject of review: Two recent stud...

journal_title：Nephron

authors： Tandukar S,Fried LF

更新日期：2018-01-01 00:00:00

abstract：:Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...

journal_title：Nephron

authors： Puschett JB,Fernandez PC

更新日期：1977-01-01 00:00:00

abstract：:The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from ...

journal_title：Nephron

authors： Higgins RM,Bevan DJ,Vaughan RW,Phillips AO,Snowden S,Bewick M,Scoble JE,Hendry BM

更新日期：1996-01-01 00:00:00

abstract：:Classic renal tubular acidosis is characterized by a primary defect in establishment of a large hydrogen ion gradient across the distal renal tubule. Thus the development of hyperchlorenic metabolic acidosis follows. In addition, hypokalemia results from renal potassium wasting secondary hyperaldosteronism from sodium...

journal_title：Nephron

authors： Chan JC

更新日期：1979-01-01 00:00:00

abstract：:A 65-year-old man with sclerosing mesenteritis developed the nephrotic syndrome. Percutaneous renal biopsy revealed classical histologic findings of minimal change nephropathy with a mild interstitial nephritis. Immunomodulation with prednisone led to a rapid and complete remission of the proteinuria but did not alter...

journal_title：Nephron

authors： Vernace MA,Bellucci AG,Mossey RT,Susin M,Mailloux LU,Wilkes BM,Katz S,Eskreis D

更新日期：1996-01-01 00:00:00

abstract：:Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte and glomerulus injury. FSGS can be primary and secondary to other diseases or due to a genetic cause. Strikingly, genetic causes for adult-onset FSGS are often overlooked, likely because identifying patients with genetic forms of FSGS base...

journal_title：Nephron

authors： Snoek R,Nguyen TQ,van der Zwaag B,van Zuilen AD,Kruis HME,van Gils-Verrij LA,Goldschmeding R,Knoers NVAM,Rookmaaker MB,van Eerde AM

更新日期：2019-01-01 00:00:00

abstract：:Renal scarring is considered to be a characteristic of reflux nephropathy. The effects of ulinastatin, a strong inhibitor of polymorphonuclear leukocyte elastase, on renal scarring following direct parenchymal or intravesical ascending infection by Serratia marcescens or Escherichia coli were determined. Four days of ...

journal_title：Nephron

authors： Matsumoto T,Haraoka M,Mizunoe Y,Takahashi K,Kubo S,Sakumoto M,Tanaka M,Kumazawa J

更新日期：1995-01-01 00:00:00

abstract：:Secondary hyperparathyroidism is common in chronic renal failure and is due to inadequate synthesis of calcitriol, the active metabolite of vitamin D. Intravenous administration of alphacalcidol, a synthetic analogue which is metabolized to calcitriol, was given during 12 weeks to 51 patients on chronic hemodialysis i...

journal_title：Nephron

authors： Ljunghall S,Althoff P,Fellström B,Marjanovic B,Nisell J,Weiss L,Wide L

更新日期：1990-01-01 00:00:00

abstract：:Isolated hindquarters of bilaterally nephrectomized and sham-operated rats were perfused in the presence and absence of 14C-labelled serine, respectively. After a perfusion period of 30 min 14C-serine was 4,074 +/- 270 dpm/ml in the perfusion medium of sham-operated animals and decreased to 2,800 +/- 190 dpm/ml in the...

journal_title：Nephron

authors： Djovkar A,Hörl WH,Heidland A

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) is an ideal model for testing remote monitoring (RM). In this study, we evaluated the RM application longitudinally in stable patients undergoing automated PD (APD). METHODS:This was an observational study, comparing outcomes in patients with (current patients) and without (historic...

journal_title：Nephron

authors： Milan Manani S,Rosner MH,Virzì GM,Giuliani A,Berti S,Crepaldi C,Ronco C

更新日期：2019-01-01 00:00:00

abstract：:Renal handling of urate, xanthine and hypoxanthine was studied in a hypouricemic patient who had increased plasma concentrations of xanthine and hypoxanthine. The patient, a 50-year-old man, had been suffering from Parkinson's disease, while neither systemic disorders nor particular renal diseases known to affect plas...

journal_title：Nephron

authors： Kawachi M,Kono N,Kiyokawa H,Mineo I,Nakajima H,Shimizu T,Yorifuji S,Kuwajima M,Tarui S

更新日期：1992-01-01 00:00:00

abstract：:In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals. Using Indian ink as a marker, rupture of the forniceal epithelium regularly followed V-U reflux. Intrapelvic pressure rose to 120 mm Hg during the reflu...

journal_title：Nephron

authors： Morgan M,Asscher AW,Moffat DB

更新日期：1976-01-01 00:00:00

abstract：:In this study, we examined the hypothesis whether exogenous administration of L-lysine in drinking water would reduce nonenzymatic glycation of glomerular basement membrane (GBM) collagen and thus albuminuria in streptozotocin-diabetic rats. The rationale is that the administered lysine would combine with the circulat...

journal_title：Nephron

authors： Jyothirmayi GN,Modak R,Reddi AS

更新日期：2001-02-01 00:00:00

abstract：:As the nephron population diminishes and azotemia develops, each remaining nephron adapts and increases its function by as much as 80%. To determine whether this adaption is permanent or transient, a rat model utilizing one remnant kidney and one normal control kidney was used. In stage one, immediately after ligation...

journal_title：Nephron

authors： Shankel SW,McDaniel J

更新日期：1982-01-01 00:00:00

abstract：:Radial arterial spasm in uremic patients undergoing construction of internal arteriovenous (AV) dialysis fistulas was investigated transcutaneously using ultrasonic Doppler flowmetry. In 5 of 15 patients, radial arterial blood flow was significantly decreased 5 min after anastomosing the radial cephalic vein with the ...

journal_title：Nephron

authors： Owada A,Saito H,Mochizuki T,Tanaka M,Otsuka M,Yokoyama Y,Fukuda S

更新日期：1993-01-01 00:00:00

abstract：:The effect of the length of hemodialysis on the outcome of renal transplant was evaluated in 43 recipients of renal allograft. 22 out of 23 patients (95.7%) dialyzed for longer than one year had an excellent renal function at one year, while only 10 out of 20 patients (50%) dialyzed for less than one year had good ren...

journal_title：Nephron

authors： Rashid A,Sengar DP,Couture RA,Posen GA,Harris JE

更新日期：1975-01-01 00:00:00

abstract：:A 55-year-old white male, with silicosis diagnosed 10 years earlier, presented massive proteinuria with microscopic hematuria, moderate renal failure and distal polyneuropathy. Bilateral renal angiography showed multiple intraparenchymal saccular aneurysms. Renal biopsy disclosed a focal segmental necrotizing glomerul...

journal_title：Nephron

authors： Arnalich F,Lahoz C,Picazo ML,Monereo A,Arribas JR,Martínez Ara J,Vázquez JJ

更新日期：1989-01-01 00:00:00

abstract：:In earlier studies, we have shown that induction of passive Heymann nephritis (PHN) by intrarenal infusion of anti-Fx1A antibodies provokes an immediate fall in renal blood flow (RBF) and glomerular filtration rate (GFR). This was probably mediated via the complement system, as infusion of the F(ab')2 fraction of anti...

journal_title：Nephron

authors： Sekse I,Iversen BM,Daha MR,Ofstad J

更新日期：1992-01-01 00:00:00