Abstract:
:Amyloid P component (AP) is a matrix glycoprotein of adult renal glomeruli. To establish whether the deposition of AP in glomeruli is an age-related phenomenon, this study used indirect immunofluorescence (IF) to investigate 34 renal biopsy specimens and 11 renal autopsy specimens. The biopsy specimens were taken from 9 patients (age range from 2 to 38 years) with normal glomerular morphology and from 25 patients (age range from 4 to 56 years) with various renal diseases. All autopsy specimens (age range form 2 months to 28 years) showed normal glomerular morphology. AP was not detected in glomeruli before age 6. By age 14, the IF intensity reached the level of the adult specimens, in which a strong fluorescence was seen along the basement membranes and within the mesangial matrix. In renal diseases, glomerular AP also appeared after age 6, although varying in its location and intensity. In conclusion, our results indicate that the appearance of AP in glomeruli is an age-related phenomenon, the pattern of which varies in renal diseases.
journal_name
Nephronjournal_title
Nephronauthors
Rantala IS,Helin HJ,Mustonen JT,Reunala Tdoi
10.1159/000190315subject
Has Abstractpub_date
1997-01-01 00:00:00pages
399-403issue
4eissn
1660-8151issn
2235-3186journal_volume
77pub_type
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