Abstract:
:The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the incidence of acute tubular necrosis between splenectomized and nonsplenectomized patients who received cadaveric grafts or kidneys from living related donors. In those patients in the cadaveric group who had acute tubular necrosis, the duration of need for dialysis was significantly less (p less than 0.05) in the splenectomized group (means = 8.9 days) when compared to the non-splenectomized group (means = 13.2 days). Animal experiments indicate that sustained prostaglandin release may be responsible for the decreased incidence and amelioration of acute tubular necrosis in splenectomized animals. Our study suggests that conclusions made in dogs about the influence of splenectomy on acute tubular necrosis may be applied to humans. Prostaglandin infusion may be a worthwhile method to abolish or ameliorate human acute tubular necrosis.
journal_name
Nephronjournal_title
Nephronauthors
Pru CE,Fryd DS,Kjellstrand CMdoi
10.1159/000183150subject
Has Abstractpub_date
1984-01-01 00:00:00pages
187-90issue
3eissn
1660-8151issn
2235-3186journal_volume
36pub_type
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