Agreement between the classical urea kinetic model and direct dialysis quantification: importance of urea rebound.

Abstract:

:From a review of the literature regarding kinetic models used for assessing the adequacy of hemodialysis, no definite conclusions can be drawn as to whether the classical urea kinetic model (UKM) or modified direct dialysis quantification (mDDQ) is more reliable. We compared mDDQ with classical UKM and with a modified UKM that employs an equilibrated urea value. From the theoretical viewpoint, no substantial conflict is found between the two models as regards the dialysis dose, if urea rebound is considered. From the practical viewpoint, in our opinion direct quantification lends itself better for experimental purposes whereas for routine Kt/V evaluation UKM is easier and accurate enough, provided that rebound is taken into account.

journal_name

Nephron

journal_title

Nephron

authors

Bosticardo GM,Alloatti S

doi

10.1159/000189473

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

674-9

issue

4

eissn

1660-8151

issn

2235-3186

journal_volume

74

pub_type

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