Altered interleukin-1 production in patients undergoing hemodialysis.

Abstract:

:The capacity of peripheral blood mononuclear cells (PBMC) to undergo spontaneous and induced interleukin-1 (IL-1) production was examined in 10 healthy controls and in 10 patients undergoing intermittent hemodialysis (HD) using cuprophane membranes. Extracellular and cytoplasmic IL-1 activity was assayed by biologic and radioimmunologic methods. Spontaneous extracellular IL-1 activity was low in the patient and the control groups. However, spontaneous cytoplasmic IL-1 activity was greatly increased in the patients. Both assays gave comparable results. In contrast, the IL-1 response to lipopolysaccharide was significantly decreased in PBMC from the patients compared to controls. From these results we conclude that PBMC from HD patients show functional signs of activation, but an impaired response to exogenous stimuli, such as endotoxin.

journal_name

Nephron

journal_title

Nephron

authors

Blumenstein M,Schmidt B,Ward RA,Ziegler-Heitbrock HW,Gurland HJ

doi

10.1159/000185187

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

277-81

issue

4

eissn

1660-8151

issn

2235-3186

journal_volume

50

pub_type

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