Abstract:
:The techniques of bonding of anionic antibiotics by treatment with cationic surfactants were applied to continuous ambulatory peritoneal dialysis (CAPD) catheters. The elution of 14C-penicillin from tridodecylmethylammonium chloride (TDMAC) treated silicone elastomer catheters in dialysis solution was biphasic, with 95% dissociated from the catheter by 48 h. Forty percent of the TDMAC left the catheter surface during the initial 2 days. The ability of the surfactant TDMAC to bind antibiotics after incubation in dialysis solution correlated directly with the amount of surfactant remaining. Rats with intraperitoneal dialysis catheters were inoculated with exit site and intraluminal bacterial challenges. Intraperitoneal catheter tips treated with TDMAC-penicillin were rendered more resistant to colonization after exit site and intraluminal bacterial challenges.
journal_name
Nephronjournal_title
Nephronauthors
Trooskin SZ,Donetz AP,Baxter J,Harvey RA,Greco RSdoi
10.1159/000184366subject
Has Abstractpub_date
1987-01-01 00:00:00pages
263-7issue
3eissn
1660-8151issn
2235-3186journal_volume
46pub_type
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