Infection-resistant continuous peritoneal dialysis catheters.

Abstract:

:The techniques of bonding of anionic antibiotics by treatment with cationic surfactants were applied to continuous ambulatory peritoneal dialysis (CAPD) catheters. The elution of 14C-penicillin from tridodecylmethylammonium chloride (TDMAC) treated silicone elastomer catheters in dialysis solution was biphasic, with 95% dissociated from the catheter by 48 h. Forty percent of the TDMAC left the catheter surface during the initial 2 days. The ability of the surfactant TDMAC to bind antibiotics after incubation in dialysis solution correlated directly with the amount of surfactant remaining. Rats with intraperitoneal dialysis catheters were inoculated with exit site and intraluminal bacterial challenges. Intraperitoneal catheter tips treated with TDMAC-penicillin were rendered more resistant to colonization after exit site and intraluminal bacterial challenges.

journal_name

Nephron

journal_title

Nephron

authors

Trooskin SZ,Donetz AP,Baxter J,Harvey RA,Greco RS

doi

10.1159/000184366

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

263-7

issue

3

eissn

1660-8151

issn

2235-3186

journal_volume

46

pub_type

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