Abstract:
:Clearance and in vitro microperfusion studies were performed in rabbits to determine the effect of cisplatin on proximal straight tubule transport of calcium and magnesium. Rabbits were injected with cisplatin (2.5 mg/kg i.p. once weekly) for 3 weeks, whereas control rabbits received normal saline solution which served as a diluent for cisplatin. In 5 rabbits, 24-hour clearance studies were performed with the aid of a metabolic cage. Following cisplatin treatment, fractional excretion of magnesium rose significantly (73.3 +/- 11.5 vs. 111.4 +/- 17.5%). Glomerular filtration rate fell with cisplatin treatment (4.05 +/- 0.76 vs. 2.81 +/- 28 ml/min). There was no difference in fractional excretion of calcium (26.3 +/- 9.5 vs. 22.7 +/- 3.2%). The cortical and juxtamedullary proximal straight tubules were perfused in vitro. Net volume absorption was the same in the control and cisplatin-treated rabbits. However, there was a significant reduction in JCa (cortical 0.57 +/- 0.10 vs. -0.10 +/- 0.12 pmol/min/mm; juxtamedullary 0.96 +/- 0.17 vs. 0.31 +/- 0.37 pmol/min/mm) and JMg (cortical 0.43 +/- 0.08 vs. -0.15 +/- 0.07 pmol/min/mm; juxtamedullary 0.40 +/- 0.27 vs. -0.30 +/- 0.28 pmol/min/mm). In contrast to chronic administration, acute addition of cisplatin into the bath had no effect on JCa and JMg in the cortical and juxtamedullary proximal straight tubules. These data indicate that chronic but not acute cisplatin treatment depresses the transport of calcium and magnesium in the cortical and juxtamedullary nephrons of the proximal straight tubule of the rabbit.
journal_name
Nephronjournal_title
Nephronauthors
Wong NL,Sutton RA,Dirks JHdoi
10.1159/000184988subject
Has Abstractpub_date
1988-01-01 00:00:00pages
62-6issue
1eissn
1660-8151issn
2235-3186journal_volume
49pub_type
杂志文章相关文献
NEPHRON文献大全abstract::The renal biopsies of 15 patients affected by polydipsia syndromes were examined under light and electron microscopes. The authors contend that the observed renal lesions (dilatation of the glomerular loops, tubular hypertrophy and vacuolization, and basal membrane swelling) are the morphologic result of tubular hyper...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180606
更新日期:1976-01-01 00:00:00
abstract::The methodology for the collection, extraction, separation and measurement of urinary angiotensin II [the octapeptide, ANG(1-8)] is described. To determine the origin of urinary ANG(1-8), mean arterial pressure, renal hemodynamics and the arterial, renal venous and urinary concentrations of ANG(1-8) were examined prio...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000188215
更新日期:1994-01-01 00:00:00
abstract::The pharmacokinetics of procainamide in patients on continuous ambulatory peritoneal dialysis have been studied. A mean peak plasma concentration of 3.2 +/- 0.6 microgram/ml was achieved about 2 h after a single 500-mg oral procainamide hydrochloride dose. The procainamide elimination half-life ranged from 6.1 to 15.3...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183984
更新日期:1986-01-01 00:00:00
abstract::A retrospective study of 100 patients followed for 1-4 years after successful renal transplantation was undertaken to assess the amelioration of previously present metabolic bone disease and to determine the risk factors associated with the development of osteonecrosis. 42% of patients showed some evidence of bony abn...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181455
更新日期:1978-01-01 00:00:00
abstract::The assessment of the hypothalamic-pituitary-adrenal axis in patients with chronic renal failure (CRF) on hemodialysis is often hampered by abnormal responses to the standard 1-mg dexamethasone suppression test. Various mechanisms have been proposed to explain this lack of suppressibility. The present study was design...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045132
更新日期:1998-09-01 00:00:00
abstract::The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000189281
更新日期:1996-01-01 00:00:00
abstract::Oral phosphatidylcholine at 900 mg/day was given to 4 patients with high lymph absorption for 8 weeks. Fluid and solute transfer before and after treatment were compared to 4 similar controls given placebo. None of the patients had overt ultrafiltration problems. After treatment, overnight peritoneal effluent phosphol...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000186527
更新日期:1991-01-01 00:00:00
abstract::A new case of acute renal failure after rifampicin is presented, together with a review of the 36 similar cases published up to date in the literature. Evidence is provided that irregularities in drug intake, either as true intermittent treatment or as discontinuation of continuous therapy, play an important role in t...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180596
更新日期:1976-01-01 00:00:00
abstract::We attempted to treat 5 patients on CAPD with fungal peritonitis without removing the catheter. In 1 case, amphotericin B caused a severe chemical peritonitis. The other 4 patients received amphotericin B intravenously and miconazole or flucytosine intraperitoneally. Recovery was obtained in 3 cases without removing t...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183582
更新日期:1985-01-01 00:00:00
abstract::A long-term hemodialysis male patient was known to have systemic iron overload due to regular blood transfusions. As he was suspected to have aluminum overload, he received a single intravenous administration of desferrioxamine (that supported the hypothesis). Four days later, he became highly febrile with no focus of...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185208
更新日期:1988-01-01 00:00:00
abstract::The effect of treatment with 1 alpha-hydroxycholecalciferol (1 alpha-OH-D3) and different diets on uremic arterial disease was studied. Three groups of rabbits with chronic renal failure (CRF) were kept on three diets with a low, medium or high content of calcium and phosphate. Half the rabbits in each group were trea...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183007
更新日期:1983-01-01 00:00:00
abstract::Isolated hindquarters of bilaterally nephrectomized and sham-operated rats were perfused in the presence and absence of 14C-labelled serine, respectively. After a perfusion period of 30 min 14C-serine was 4,074 +/- 270 dpm/ml in the perfusion medium of sham-operated animals and decreased to 2,800 +/- 190 dpm/ml in the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183003
更新日期:1983-01-01 00:00:00
abstract::In an effort to elucidate immunopathogenic of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed of circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181675
更新日期:1979-01-01 00:00:00
abstract::Bone mineral content (BMC) was measured at the lumbar spine region by means of dual photon absorptiometry over a 3-year period in 20 patients on regular hemodialysis (RHD). Baseline mean BMC at the start of the monitoring was significantly decreased to 82.64% of predicted value (p less than 0.05). During a 3-year foll...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185620
更新日期:1989-01-01 00:00:00
abstract::Increased free-radical production leading to oxidative stress may contribute to the development of cardiovascular complications in haemodialysis patients. The ferroxidase activity of caeruloplasmin forms an important component of antioxidant defences in body fluids. The aim of this study was to assess ferroxidase acti...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045579
更新日期:2000-03-01 00:00:00
abstract::The decarboxylation and transamination reactions of glyoxylate, which divert this precursor from oxalate formation, have been investigated. Decarboxylation of glyoxylate is synergistic with 2-oxoglutarate and catalysed by 2-oxoglutarate:glyoxylate carboligase which co-chromatographs with the 2-oxoglutarate dehydrogena...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186350
更新日期:1991-01-01 00:00:00
abstract::Postnephrectomy serum has been proved to enhance proliferation of mesangial cells in culture. Studies in offspring to uninephrectomized (UNx) mothers indicate that it remains active for a long period following UNx. On the other hand, postnephrectomy renal compensatory growth in vivo is known to be completed within a s...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044913
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Little is known about the effect of posttransplant opioid use on adherence to immunosuppressant therapy (IST) among adult renal transplant recipients (RTRs). OBJECTIVE:The aim of this study was to examine the relationship between opioid use and IST adherence among adult RTRs during the first year posttran...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000507257
更新日期:2020-01-01 00:00:00
abstract::A 55-year-old white male, with silicosis diagnosed 10 years earlier, presented massive proteinuria with microscopic hematuria, moderate renal failure and distal polyneuropathy. Bilateral renal angiography showed multiple intraparenchymal saccular aneurysms. Renal biopsy disclosed a focal segmental necrotizing glomerul...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185391
更新日期:1989-01-01 00:00:00
abstract::The parathyroid gland responsiveness to hypocalcemia induced by short-term calcium-free hemodialysis in patients with insulin-dependent diabetes mellitus was investigated in comparison with 10 nondiabetic uremic patients and compared with test results from the autonomic nervous system. Diabetic patients had lower C-te...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183689
更新日期:1986-01-01 00:00:00
abstract::Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a new autosomal form of hypophosphatemic rickets, recently described. This disease is characterized, and differs from other forms of hereditary hypophosphatemic rickets and/or osteomalacia by increased serum levels of 1,25-dihydroxyvitamin D, hypercalci...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187029
更新日期:1992-01-01 00:00:00
abstract::The morphologic basis of proteinuria in experimental chronic serum sickness glomerulonephritis in rabbits was studied by light and electron microscopy using horseradish peroxidase (effective radius 30 A; mol. wt. 40,000) and ferritin (effective radius 60 A; mol. wt. 480,000) as protein tracers. It was found that more ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181260
更新日期:1978-01-01 00:00:00
abstract::Inflammation is broadly recognized as an important factor in the pathogenesis of acute kidney injury (AKI), but pharmacological approaches to alleviate inflammation in AKI have been without success in clinical trials. Neuromodulation by nonpharmacological methods is emerging as a novel therapeutic strategy to treat in...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000477218
更新日期:2017-01-01 00:00:00
abstract::The accumulation in blood plasma and efficiency of hemodialysis of pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronic renal failure (CRF) was investigated. As a reference, the analysis of the above metabolites in the plasma of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187313
更新日期:1993-01-01 00:00:00
abstract::The effect of the length of hemodialysis on the outcome of renal transplant was evaluated in 43 recipients of renal allograft. 22 out of 23 patients (95.7%) dialyzed for longer than one year had an excellent renal function at one year, while only 10 out of 20 patients (50%) dialyzed for less than one year had good ren...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180475
更新日期:1975-01-01 00:00:00
abstract::To probe renal hemodynamic measurements in relation to simultaneous systemic hemodynamic measurements in normal, adult, conscious dogs on a magnesium-deficient diet, 6 experimental animals were given 4 weeks of a magnesium-deficient diet compared to 9 animals whose dietary magnesium was normal. Systemic hemodynamics w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185169
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND/AIMS:The renal prognosis of post-renal acute kidney injury (PoR-AKI) has not been verified so far. The objective of this study was to assess the association of baseline anemia with long-term renal prognosis in patients with PoR-AKI. METHODS:We performed a multicenter retrospective cohort study. Consecutive ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000452810
更新日期:2017-01-01 00:00:00
abstract::The authors report on the presence of anti-HCV antibodies in a uremic chronic (UC) patient population after 6 months and 1 year with regard to certain selective preventive measures. The nonincreased number of HCV-positive subjects among the UC population could lead to the conclusion that the risk of environmental spre...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186941
更新日期:1992-01-01 00:00:00
abstract::Both the plasma determinations of erythropoietic (EPO) and transferrin receptor (TfR) would provide a good characterization of anemia especially when mixed erythron disorders underlie, such as in renal failure. Immunologic assays of EPO and TfR, as well as standard hematologic determinations (hematocrit, reticulocyte ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000188938
更新日期:1996-01-01 00:00:00
abstract::In kidney allografts, focal segmental glomerulosclerosis (FSGS) has been described as recurrent, de novo, or a histological variant of chronic transplant glomerulopathy. We describe a unique case of de novo FSGS in a renal transplant not accompanied by any feature of rejection in a patient who had not been immunosuppr...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045412
更新日期:1999-01-01 00:00:00