Abstract:
:The pharmacokinetics of procainamide in patients on continuous ambulatory peritoneal dialysis have been studied. A mean peak plasma concentration of 3.2 +/- 0.6 microgram/ml was achieved about 2 h after a single 500-mg oral procainamide hydrochloride dose. The procainamide elimination half-life ranged from 6.1 to 15.3 h. Apparent oral clearance, 183.7 +/- 63.2 ml/min, was less than half that observed in healthy adults suggesting markedly reduced dosage requirements. Continuous ambulatory dialysis patients exhibit similar procainamide pharmacokinetic parameters as do end stage renal disease patients, most notably a prolonged elimination half-life and reduced oral clearance.
journal_name
Nephronjournal_title
Nephronauthors
Raehl CL,Moorthy AV,Beirne GJdoi
10.1159/000183984subject
Has Abstractpub_date
1986-01-01 00:00:00pages
191-4issue
3eissn
1660-8151issn
2235-3186journal_volume
44pub_type
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