Procainamide pharmacokinetics in patients on continuous ambulatory peritoneal dialysis.

Abstract:

:The pharmacokinetics of procainamide in patients on continuous ambulatory peritoneal dialysis have been studied. A mean peak plasma concentration of 3.2 +/- 0.6 microgram/ml was achieved about 2 h after a single 500-mg oral procainamide hydrochloride dose. The procainamide elimination half-life ranged from 6.1 to 15.3 h. Apparent oral clearance, 183.7 +/- 63.2 ml/min, was less than half that observed in healthy adults suggesting markedly reduced dosage requirements. Continuous ambulatory dialysis patients exhibit similar procainamide pharmacokinetic parameters as do end stage renal disease patients, most notably a prolonged elimination half-life and reduced oral clearance.

journal_name

Nephron

journal_title

Nephron

authors

Raehl CL,Moorthy AV,Beirne GJ

doi

10.1159/000183984

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

191-4

issue

3

eissn

1660-8151

issn

2235-3186

journal_volume

44

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Hypocomplementemic type II membranoproliferative glomerulonephritis in a male patient with familial lecithin-cholesterol acyltransferase deficiency due to two different allelic mutations.

    abstract::Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000046001

    authors: Sessa A,Battini G,Meroni M,Daidone G,Carnera I,Brambilla PL,Viganò G,Giordano F,Pallotti F,Torri Tarelli L,Calabresi L,Rolleri M,Bertolini S

    更新日期:2001-07-01 00:00:00

  • Is Chronic Kidney Disease Progression Influenced by the Type of Renin-Angiotensin-System Blocker Used?

    abstract:INTRODUCTION:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) reduce proteinuria and slow renal disease progression more effectively than other therapies in patients with chronic kidney disease (CKD). However, differences regarding efficacy and safety between these therapies rem...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000500925

    authors: Silvariño R,Rios P,Baldovinos G,Chichet MA,Perg N,Sola L,Saona G,De Souza N,Lamadrid V,Gadola L

    更新日期:2019-01-01 00:00:00

  • Prevalence of hyperoxaluria in idiopathic calcium oxalate kidney stone disease.

    abstract::Urinary excretion of oxalate, calcium and urate has been investigated in 88 patients affected by idiopathic calcium oxalate stone disease and in 20 normal subjects. Of these ions, only oxalate was found significantly higher in stone formers. Defining hyperoxaluria as urinary oxalate excretion greater than 2 SD above n...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183037

    authors: Baggio B,Gambaro G,Favaro S,Borsatti A

    更新日期:1983-01-01 00:00:00

  • Hyperreninemia and secondary hyperaldosteronism in a patient with pheochromocytoma and von Hippel-Lindau disease.

    abstract::In a 21-year-old Caucasian women with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of cap...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187071

    authors: Lenz T,Thiede HM,Nussberger J,Atlas SA,Distler A,Schulte KL

    更新日期:1992-01-01 00:00:00

  • Cytotoxicity of commercial peritoneal dialysis solutions towards peritoneal cells of chronically uremic mice.

    abstract::A gradual loss of cell viability was observed during in vitro incubation of peritoneal cells from chronically uremic mice in commercial peritoneal dialysis solutions. The magnitude of this cytotoxicity toward peritoneal cells harvested from uremic mice and controls was comparable. Resident peritoneal cells were always...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183855

    authors: Gallimore B,Gagnon RF,Stevenson MM

    更新日期:1986-01-01 00:00:00

  • Association of class II antigens of HLA with primary glomerulopathies.

    abstract::HLA antigens of Japanese patients with primary glomerulopathies were determined, and the frequency of each HLA antigen was compared with that of Japanese normal controls. IgA nephropathy with HLA-DR4, idiopathic membraneous glomerulopathy with DR2, lipoid nephrosis with DRw53 and poststreptococcal glomerulonephritis w...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184089

    authors: Naito S,Kohara M,Arakawa K

    更新日期:1987-01-01 00:00:00

  • Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients?

    abstract::Pruritus is a common symptom among patients undergoing long-term hemodialysis. However, its etiology remains unclear. In an attempt to clarify its cause we tried to correlate pruritus and its intensity with several serological variables in 94 hemodialysis patients. Our results show that higher serum aluminum concentra...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189499

    authors: Friga V,Linos A,Linos DA

    更新日期:1997-01-01 00:00:00

  • Competition between low- and high-molecular-weight proteins for renal tubular uptake.

    abstract::To explain the occurrence of tubular and glomerular proteinuria in patients with primarily tubular or glomerular dysfunction, it is usually assumed that the mechanisms responsible for the renal tubular transport of small and large proteins are different. The present in vivo study does not support this hypothesis since...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184090

    authors: Bernard A,Viau C,Ouled A,Lauwerys R

    更新日期:1987-01-01 00:00:00

  • HCV infections in dialysis patients.

    abstract::HCV is seen as an emergent problem in Dialysis Units; in fact, the patients of these centers are at high risk for blood-transmitted infections, through coming microepidemies. For this reason and using the same method, we have studied the prevalence of anti-HCV and virus-derived hepatitis in a dialytic population of 10...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186922

    authors: Scotto G,Savastano AM,Forcella M,Tantimonaco G,Amato G,Salatino G,Pappani A,Stella I

    更新日期:1992-01-01 00:00:00

  • Urine osmolarity predicts the body weight-reduction response to tolvaptan in chronic kidney disease patients: a retrospective, observational study.

    abstract:BACKGROUND/AIMS:Tolvaptan, a vasopressin V2 receptor antagonist, promotes the excretion of electrolyte-free water. Patients with heart failure or liver cirrhosis, whose urine osmolarity is high due to increased vasopressin, show a good response to tolvaptan; however, it remains dubious whether tolvaptan is also effecti...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000381859

    authors: Iwatani H,Kawabata H,Sakaguchi Y,Yamamoto R,Hamano T,Rakugi H,Isaka Y

    更新日期:2015-01-01 00:00:00

  • Guidelines for Classification of Acute Kidney Diseases and Disorders.

    abstract::Recent efforts have standardized definitions and classification systems for acute kidney injury (AKI) and chronic kidney disease (CKD). These efforts have enhanced communication, recognition, and awareness of acute and CKDs and stimulated research on both disorders. However, abnormalities of kidney function and struct...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000441425

    authors: Barry R,James MT

    更新日期:2015-01-01 00:00:00

  • Clinicopathological study of patients with mesangial isolated C3d deposition in various glomerular diseases.

    abstract::The clinicopathological findings of isolated mesangial C3d deposition in the absence of other complement components or immunoglobulins are summarized. 55 out of 242 individual human renal biopsies examined by immunoperoxidase microscopy had isolated C3d deposition. This group consisted of 12 patients with chronic glom...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184339

    authors: Doi T,Kanatsu K,Suehiro F,Nagai H,Yoshida H,Hamashima Y

    更新日期:1987-01-01 00:00:00

  • Parathyroidectomy in chronic renal failure.

    abstract::Parathyroidectomy was carried out in 26 patients over a 14-year period. Excellent results were obtained in patients with severe hyperparathyroidism. Vascular calcification, hypercalcaemia and pruritus did not justify surgery unless associated with unequivocal hyperparathyroidism. 13 patients required intravenous calci...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182921

    authors: Dawborn JK,Brown DJ,Douglas MC,Eddey HH,Heale WF,Thomas DP,Xipell JM

    更新日期:1983-01-01 00:00:00

  • Clinical features and severity of nonspecific symptoms in dialysis patients.

    abstract::Nonspecific symptoms are common in dialysis patients but few methods are available to measure their severity and their response to alteration in dialysis therapy. To determine the clinical features and measure the severity of the most important symptoms in end-stage renal disease (ESRD) patients, 97 dialysis patients ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185141

    authors: Parfrey PS,Vavasour HM,Henry S,Bullock M,Gault MH

    更新日期:1988-01-01 00:00:00

  • HDL cholesterol and TaqIB cholesteryl ester transfer protein gene polymorphism in renal transplant recipients.

    abstract::Decreased serum levels of high-density lipoprotein cholesterol (HDL-C) are a well-known risk factor for coronary heart disease (CHD) in the general population and have been suggested as one of the best predictor of CHD after renal transplantation. However, very heterogeneous HDL-C levels have been reported in renal tr...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045608

    authors: Radeau T,Vohl MC,Houde I,Lachance JG,Noël R,Després JP,Douville P,Bergeron J

    更新日期:2000-04-01 00:00:00

  • Increased urinary excretion of interleukin-17 in nephrotic patients.

    abstract:BACKGROUND/AIM:Interleukin (IL)-17 is a newly discovered cytokine that is secreted by activated memory CD4+ T cells and modulated the early stage of immune response. To elucidate the pathophysiology of minimal-change nephrotic syndrome (MCNS), we focused on IL-17, which is one of the key factors in regulating an inflam...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000058399

    authors: Matsumoto K,Kanmatsuse K

    更新日期:2002-06-01 00:00:00

  • Influence of long-term amelioration of anemia and blood pressure control on left ventricular hypertrophy in hemodialyzed patients.

    abstract::The course of left ventricular hypertrophy was investigated in anemic hemodialysis patients treated with recombinant human erythropoietin (r-huEPO). 12 patients, aged 60.8 +/- 9.9 years (mean +/- SD) were treated for 18.8 +/- 2.7 months. Left ventricular size was estimated by echocardiography performed before treatmen...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186829

    authors: Zehnder C,Zuber M,Sulzer M,Meyer B,Straumann E,Jenzer HR,Blumberg A

    更新日期:1992-01-01 00:00:00

  • Characteristic matrix and tubular basement membrane abnormalities in the CBA/Ca-kdkd mouse model of hereditary tubulointerstitial disease.

    abstract::CBA/CaH-kdkd mice develop hereditary tubulointerstitial disease with mononuclear cell infiltration and cyst formation, possibly representing a model of human nephronophthisis. The purpose of the present investigation was to examine the components of the fibrotic changes which typically develop in the kidneys of these ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045191

    authors: Sibalic V,Sun L,Sibalic A,Oertli B,Ritthaler T,Wüthrich RP

    更新日期:1998-11-01 00:00:00

  • Effect of the immunosuppressive agent, ciclosporin, on experimental immune complex glomerulonephritis in rats.

    abstract::Effect of the immunosuppressive agent, ciclosporin (CS), on bovine serum albumin (BSA) nephritis in rats was evaluated. Eight weeks after immunization, 19 male Wistar rats received a daily intravenous dose of BSA (2 mg). Two weeks later, 11 rats received BSA and an oral dose of CS (10 mg/kg), and 8 rats received only ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186251

    authors: Fujita M,Iida H,Asaka M,Izumino K,Takata M,Sasayama S

    更新日期:1991-01-01 00:00:00

  • Increased clearance rate of prednisone in the isolated perfused liver of uremic rats.

    abstract::The effect of uremia upon the hepatic clearance rate of prednisone was studied in isolated perfused livers of normal and uremic female rats. The perfusion rate was kept at a constant flow rate of 25 ml/min. In order to induce uremia, one group of rats was 5/6 nephrectomized 3 weeks prior to the perfusions. The concent...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184072

    authors: Egfjord W,Langhoff E,Daugaard H,Olgaard K

    更新日期:1987-01-01 00:00:00

  • Protection of renal function and of nutritional status in uremic rats by means of a low-protein, low-phosphorus supplemented diet.

    abstract::A low-protein, low-phosphorus diet supplemented with essential amino acids and keto analogues was given to 12 rats, starting from the 90th day after subtotal nephrectomy. The purpose was to assess its effect on the residual renal function and on the nutritional status in rats with already established severe renal fail...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185055

    authors: Barsotti G,Moriconi L,Cupisti A,Dani L,Ciardella F,Lupetti S,Giovannetti S

    更新日期:1988-01-01 00:00:00

  • Development of calcium oxalate crystals on urothelium: effect of free radicals.

    abstract::The effects of free radicals on the development of crystals attached to the living epithelium have been studied using an experimental model that enables close simulation of the conditions prevailing in the kidney. The results obtained clearly demonstrate that free radical-damaged cells produce a favorable environment ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044939

    authors: Grases F,García-Ferragut L,Costa-Bauzá A

    更新日期:1998-01-01 00:00:00

  • Effect of probucol on hyperlipidemia in patients with nephrotic syndrome.

    abstract::We have evaluated the effect of the antihyperlipidemic agent probucol on hyperlipidemia in patients with nephrotic syndrome. Twelve patients with long-standing nephrotic syndrome received 500 mg of probucol daily for 12 weeks. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were significantl...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184524

    authors: Iida H,Izumino K,Asaka M,Fujita M,Nishino A,Sasayama S

    更新日期:1987-01-01 00:00:00

  • Cell characteristics of cultured glomeruli from different animal species.

    abstract::A modified sieving technique has been developed to isolate pure glomeruli from monkey, sheep, dog, rabbit and rat kidney. Glomeruli from all these species have been grown in tissue culture and the glomerular cell outgrowth studied by light microscopy and time-lapse cinemicroscopy. The pattern of growth was the same fo...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181513

    authors: Holdsworth SR,Glasgow EF,Atkins RC,Thomson NM

    更新日期:1978-01-01 00:00:00

  • Blood leukocyte contribution to serum ferritin levels in patients on chronic hemodialysis.

    abstract::Serum ferritin level has been shown by many investigators to be a good indicator of bone marrow iron stores in normal subjects. Although this correlation may hold in some pathological situations, it is lost in others. In leukemia a dissociation has been observed between serum ferritin levels and bone marrow iron store...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186241

    authors: Nuwayri-Salti N,Jabre F,Saab G,Daouk M,Salem Z

    更新日期:1991-01-01 00:00:00

  • Severe acute renal failure: a comparison of acute continuous hemodiafiltration and conventional dialytic therapy.

    abstract::It is unknown whether continuous renal replacement techniques result in diminished morbidity and mortality when compared to conventional dialytic techniques. To investigate this issue a previously described, retrospectively studied group of critically ill patients with severe acute renal failure treated by conventiona...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188675

    authors: Bellomo R,Farmer M,Parkin G,Wright C,Boyce N

    更新日期:1995-01-01 00:00:00

  • Involvement of interleukin-4 and soluble CD23 in hypersynthesis of immunoglobulins A and E in patients with IgA nephropathy.

    abstract::To determine the cytokines responsible for the increase in production of IgA in patients with IgA nephropathy (IgAN), the roles of interleukin-4 (IL-4) and soluble CD23 (sCD23) were examined. Peripheral blood mononuclear cells (PBMCs) and serum were obtained from 24 patients with IgAN and 14 patients with non-IgA prol...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188805

    authors: Yano N,Endoh M,Takemura F,Naka R,Kashem A,Nomoto Y,Sakai H

    更新日期:1996-01-01 00:00:00

  • Effect of oral adsorbent (AST-120) on renal function, acquired renal cysts and aortic calcification in rats with adriamycin nephropathy.

    abstract:AIMS:The effect of oral adsorbent, AST-120, on the experimental renal disease induced by adriamycin, uninephrectomy and high protein diet proposed as a model of acquired cystic disease of the kidney was investigated. METHODS:3 mg of adriamycin was injected into the tail vein of rats and 4 weeks later right-side nephre...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000063324

    authors: Ishikawa I,Araya M,Hayama T,Sugano M,Yamato H,Ise M

    更新日期:2002-10-01 00:00:00

  • Failure to reduce cholesterol as explanation for the limited efficacy of antihypertensive treatment in the reduction of coronary heart disease. Evidence from the Hypertension Detection and Follow-up program (1973-1979).

    abstract::The recent experience of six large trials of antihypertensive therapy has not clearly demonstrated any beneficial effect on the prevention of coronary heart disease (CHD). The data from the HDFP study have been analyzed by three cholesterol strata at baseline. The higher the baseline cholesterol levels, the greater th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184564

    authors: Schneider KA,Heyden S,Ford C

    更新日期:1987-01-01 00:00:00

  • Angiotensin-converting enzyme inhibitors in the treatment of diabetic glomerulopathy.

    abstract::Continuous therapy with an angiotensin-converting enzyme (ACE) inhibitor has been shown to have a glomerular vasodepressor effect in the newly diabetic rat and to largely prevent subsequent development of severe sclerosing glomerular injury. Preliminary studies in humans with established diabetic glomerular injury rev...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186031

    authors: Myers BD,Meyer TW

    更新日期:1990-01-01 00:00:00