Enhanced renal sympathetic tone in liver cirrhosis: evaluation by intrarenal administration of dihydroergocristine.

Abstract:

:Mean renal blood flow (MRBF), cortical blood flow (CBF), glomerular filtration rate (GFR), heart rate, arterial blood pressure, Na+ and K+ excretion were determined before and 10 min after intrarenal administration of dihydroergocristine (0.017 mg/kg b.w.) in 13 patients suffering from liver cirrhosis. Cardiac output was also determined in 6 patients. Baseline values of MRBF and CBF were significantly lower in cirrhotics than in the 14 control subjects. Following intrarenal administration of the drug, renal hemodynamic parameters increased significantly, while GFR decreased. Systemic hemodynamic parameters, diuresis, Na+ and K+ excretions were unchanged. These data show that dihydroergocristine has a renal vasodilator effect, probably mediated by alpha-adrenergic blockade. The effect probably is prevalent at the postglomerular site, where the increase in vascular resistance is greatest. The effect of the drug suggests that patients with liver cirrhosis have enhanced renal sympathetic activity which is, at least in part, responsible for the renal vasoconstriction.

journal_name

Nephron

journal_title

Nephron

authors

Gatta A,Merkel C,Grassetto M,Milani L,Zuin R,Ruol A

doi

10.1159/000182519

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

364-7

issue

4

eissn

1660-8151

issn

2235-3186

journal_volume

30

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Safety of Percutaneous Ultrasound-Guided Kidney Biopsy in Patients with AA Amyloidosis.

    abstract:BACKGROUND:Bleeding is the most frequent complication of kidney biopsy. Although bleeding risk in patients with AA amyloidosis after kidney biopsy has not been studied in a large population, AA amyloidosis has long been perceived as a risk factor for bleeding. The aim of the present study was to evaluate post-biopsy bl...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000437443

    authors: Altindal M,Yildirim T,Turkmen E,Unal M,Boga I,Yilmaz R,Arici M,Altun B,Erdem Y

    更新日期:2015-01-01 00:00:00

  • Hemolytic uremic syndrome as a presenting form of HIV infection.

    abstract::Human immunodeficiency virus (HIV) infection has been associated with several renal disorders. Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) were also described in several patients with overt AIDS. We describe a patient who presented with HUS and only subsequent investigation to find the caus...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000188916

    authors: Badesha PS,Saklayen MG

    更新日期:1996-01-01 00:00:00

  • Total Calcium and Albumin Are Decreased in the Deeper Epidermis of Patients with Chronic Kidney Disease-Associated Pruritus.

    abstract:BACKGROUND/AIMS:In our earlier studies, we reported high concentrations of intra- and extracellular calcium ions (Ca2+) in the deeper epidermis of patients with chronic kidney disease (CKD) and associated pruritus. To determine the cause of this phenomenon, we measured total calcium (TCa) concentrations in the deeper e...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000458417

    authors: Momose A,Shiraiwa Y,Narita S,Kusumi T,Goto S,Sera K

    更新日期:2017-01-01 00:00:00

  • Sialyl Lewis X and anti-P-selectin antibody attenuate lipopolysaccharide-induced acute renal failure in rabbits.

    abstract:BACKGROUND/AIM:Acute renal failure (ARF) is one of the common problems associated with sepsis or multiple organ dysfunction syndrome (MODS). We have investigated the effects of inhibiting selectin-mediated cell adhesion on lipopolysaccharide-induced ARF in rabbits, using sialyl Lewis X oligosaccharide and PB1.3, an ant...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045942

    authors: Hayashi H,Imanishi N,Ohnishi M,Tojo SJ

    更新日期:2001-04-01 00:00:00

  • Renal artery stenosis associated with epidermal nevus syndrome.

    abstract::Epidermal nevus syndrome is an unusual neurocutaneous disorder in which epidermal nevi are associated with abnormalities of the skeleton and central nervous system, including the eyes and somtimes the cardiovascular system. We treated a patient in whom the latter included renal artery stenosis. An 18-year-old man with...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045540

    authors: Aizawa K,Nakamura T,Ohyama Y,Saito Y,Hoshino J,Kanda T,Sumino H,Nagai R

    更新日期:2000-01-01 00:00:00

  • A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism.

    abstract::A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism, presenting severe hyponatremia, is described. A 57-year-old man complaining of nausea, vomiting and fatigability was admitted to our hospital because of hyponatremia (114 mEq/I). The low levels of serum cortisol and urinary 17-OHCS suggested gluc...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189056

    authors: Okada K,Takahashi S

    更新日期:1996-01-01 00:00:00

  • New Ways of Understanding Membranous Nephropathy.

    abstract:BACKGROUND:In the last decade, great advances have been made in the field of membranous nephropathy (MN). The autoimmune nature of the disease has been confirmed with the description of diverse antigens, and few but very important prospective trials regarding treatment alternatives have been published, changing profoun...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000506948

    authors: Trujillo H,Alonso M,Praga M

    更新日期:2020-01-01 00:00:00

  • Characteristic glomerular lesions in the ExHC rat: a unique model for lipid-induced glomerular injury.

    abstract::ExHC rats were bred from the Sprague-Dawley strain and are highly susceptible to dietary hypercholesterolemic stimuli. Although chemical and histological examination of the aorta from ExHC rats fed a diet containing 3% cholesterol, 0.6% sodium cholate and 15% olive oil (high-cholesterol diet, HCD) has been reported, r...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187216

    authors: Hattori M,Yamaguchi Y,Kawaguchi H,Ito K

    更新日期:1993-01-01 00:00:00

  • Effects of oral supplementation with evening primrose oil for six weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients.

    abstract::Abnormalities in plasma composition of essential fatty acids (EFAs) may be associated with the etiology of pruritus and other skin problems in patients undergoing hemodialysis. To study whether an oral supplementation with omega-6 (n-6) EFAs would restore deranged plasma EFAs and ameliorate skin symptoms, 9 and 7 dial...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000045271

    authors: Yoshimoto-Furuie K,Yoshimoto K,Tanaka T,Saima S,Kikuchi Y,Shay J,Horrobin DF,Echizen H

    更新日期:1999-02-01 00:00:00

  • Proliferative responses of mesangial cells to growth factors during compensatory versus dietary hypertrophy.

    abstract::While the bulk of renal hypertrophy induced by contralateral nephrectomy or a high-protein diet consists of tubular cell growth, there is some evidence suggesting that mesangial cells play a role in this phenomenon. Previous data suggest that this role of mesangial cells is associated with their proliferation. We, the...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045668

    authors: Weissgarten J,Modai D,Berman S,Cohn M,Galperin E,Averbukh Z

    更新日期:2000-07-01 00:00:00

  • Influence of splenectomy on human acute tubular necrosis.

    abstract::The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the inc...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183150

    authors: Pru CE,Fryd DS,Kjellstrand CM

    更新日期:1984-01-01 00:00:00

  • Comparison of toxic effects of methylguanidine, guanidinosuccinic acid and creatinine in rats with adenine-induced chronic renal failure.

    abstract::Methylguanidine (MG), guanidinosuccinic acid (GSA) and creatinine (Cr), which accumulate in the body in parallel with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine was given to rats for 24 days to induce renal fai...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185328

    authors: Yokozawa T,Mo ZL,Oura H

    更新日期:1989-01-01 00:00:00

  • Declining Estimated Glomerular Filtration Rate and Its Association with Mortality and Comorbidity Over 10 Years in Elderly Women.

    abstract:BACKGROUND/AIMS:Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly women. Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old women. ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000435790

    authors: Malmgren L,McGuigan FE,Berglundh S,Westman K,Christensson A,Åkesson K

    更新日期:2015-01-01 00:00:00

  • Nephrocalcinosis in Amelogenesis Imperfecta Caused by the FAM20A Mutation.

    abstract:BACKGROUND/AIMS:Enamel-renal syndrome is characterized by nephrocalcinosis, enamel defects, gingival hyperplasia and eruption failures. It has been recently identified that recessive mutations in the FAM20A gene result in amelogenesis imperfecta (AI)-gingival fibromatosis. The aim of this research to determine whether ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000486607

    authors: Koruyucu M,Seymen F,Gencay G,Gencay K,Tuna EB,Shin TJ,Hyun HK,Kim YJ,Kim JW

    更新日期:2018-01-01 00:00:00

  • Nephropathy and mixed cryoglobulinemia: evidence for an immune complex pathogenesis.

    abstract::Mixed IgM-IgG cryoglobulins were present in the serum of a patient with the nephrotic syndrome, recurrent purpura, chronic active hepatitis and ascites. A renal biopsy demonstrated deposition of IgM, IgG, and complement components C3 and C4 in intracapillary 'coagula' and glomerular capillary walls. No glomerular depo...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180591

    authors: Zimmerman SW,Dreher WH,Burkholder PM,Goldfarb S,Weinstein AB

    更新日期:1976-01-01 00:00:00

  • Desferrioxamine enhances the haemopoietic response to erythropoietin, but adverse events are common.

    abstract::To determine whether the chelation of aluminium enhances the haemopoietic response to recombinant human erythropoietin (r-HuEPO), desferrioxamine (DFO) at a dose of 20-30 mg/kg was given to 7 of 17 transfusion-dependent haemodialysis patients treated with r-HuEPO (40 units/kg/dialysis i.v.). The two randomly allocated...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000186374

    authors: Roger SD,Stewart JH,Harris DC

    更新日期:1991-01-01 00:00:00

  • The morphologic basis of proteinuria in experimental chronic serum sickness glomerulonephritis. A light and electron microscopic study using horseradish peroxidase and ferritin as tracers.

    abstract::The morphologic basis of proteinuria in experimental chronic serum sickness glomerulonephritis in rabbits was studied by light and electron microscopy using horseradish peroxidase (effective radius 30 A; mol. wt. 40,000) and ferritin (effective radius 60 A; mol. wt. 480,000) as protein tracers. It was found that more ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181260

    authors: O'Connell DW,Brentjens JR,Andres GA

    更新日期:1978-01-01 00:00:00

  • Carbamazepine-induced hyponatremia in a patient with partial central diabetes insipidus.

    abstract::A 51-year-old Japanese man was referred for the evaluation of persistent hyponatremia. The serum sodium level remained around 120 mmol/l despite mild water restriction. His past history included chronic alcoholism, myocardial infarction and lumbar disc herniation. Carbamazepine (200 mg, b.i.d.) has been used for more ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187295

    authors: Kamiyama T,Iseki K,Kawazoe N,Takishita S,Fukiyama K

    更新日期:1993-01-01 00:00:00

  • Development of calcium oxalate crystals on urothelium: effect of free radicals.

    abstract::The effects of free radicals on the development of crystals attached to the living epithelium have been studied using an experimental model that enables close simulation of the conditions prevailing in the kidney. The results obtained clearly demonstrate that free radical-damaged cells produce a favorable environment ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044939

    authors: Grases F,García-Ferragut L,Costa-Bauzá A

    更新日期:1998-01-01 00:00:00

  • Sustained-release bezafibrate corrects lipid abnormalities in patients on continuous ambulatory peritoneal dialysis.

    abstract::A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186101

    authors: Chan MK

    更新日期:1990-01-01 00:00:00

  • Acute response to captopril as a predictive test for surgery in renovascular hypertension.

    abstract::To test the hypothesis that acute angiotensin-converting enzyme (ACE) inhibition might predict the postoperative blood pressure outcome, a single oral dose of captopril ranging from 12.5 to 100 mg, was given to 26 patients with renovascular disease and its hypotensive effect was compared with that of surgery (21 patie...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184054

    authors: Salvetti A,Arzilli F,Nuccorini A,Simonini N,Glorioso N,Dessì-Fulgheri P,Madeddu P,Rappelli A

    更新日期:1986-01-01 00:00:00

  • Technique for the performance of repeatable renal clearances in the conscious male dog.

    abstract::A preparation for performance of renal clearances in the conscious dog is described. The important aspect of the technique is the use of a Pavlov sling and a specially designed restraining apparatus. Of most importance is the use of a 7 French Swan-Ganz balloon-tipped catheter for urinary bladder catheterization. The ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180595

    authors: Garner D,Laks MM

    更新日期:1976-01-01 00:00:00

  • Renal cell carcinoma complicated by emphysematous pyelonephritis in a non-diabetic patient with renal failure.

    abstract::A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064452

    authors: Lin CH,Huang JJ,Liu HL,Lee SY,Hsieh RY,Tseng CC

    更新日期:2002-09-01 00:00:00

  • The renin-aldosterone system and thiazide-induced depletion of total body potassium in essential hypertension.

    abstract::15 patients who had benign, uncomplicated essential hypertension, were treated with chlorthiazide (500 mg twice a day) with or without propranolol (10--20 mg 4 times a day), and the effect of the treatment on plasma renin activity (PRA), urinary aldosterone excretion, total body potassium (TBK) and plasma sodium and p...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000181403

    authors: Oh MS,Carroll HJ

    更新日期:1978-01-01 00:00:00

  • Involvement of interleukin-4 and soluble CD23 in hypersynthesis of immunoglobulins A and E in patients with IgA nephropathy.

    abstract::To determine the cytokines responsible for the increase in production of IgA in patients with IgA nephropathy (IgAN), the roles of interleukin-4 (IL-4) and soluble CD23 (sCD23) were examined. Peripheral blood mononuclear cells (PBMCs) and serum were obtained from 24 patients with IgAN and 14 patients with non-IgA prol...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188805

    authors: Yano N,Endoh M,Takemura F,Naka R,Kashem A,Nomoto Y,Sakai H

    更新日期:1996-01-01 00:00:00

  • Neutrophil adhesion molecules in chronic hemodialysis patients.

    abstract::The expression of the adhesion molecules LFA-1 (CD11a-CD18), Mac-1 (CD11b-CD18), and LAM-1 on predialysis and intradialysis neutrophils (PMN) was analyzed by flow cytometry in 10 chronic hemodialysis patients (CHD) and compared with age-matched normal controls. All patients were dialyzed either with a polyacrylonitril...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188255

    authors: Zachée P,Daelemans R,Pollaris P,Boogaerts MA,Lins RL

    更新日期:1994-01-01 00:00:00

  • Use of immunomodulators (thymopentine) in hepatitis B vaccine in elderly patients undergoing chronic hemodialysis.

    abstract::Thymopentine is a synthetic immunomodulator that positively affects T-lymphocyte maturation, reproduction and differentiation. In elderly uremic patients nonresponders to hepatitis B vaccine, the administration of this drug has been shown to improve the response to the new vaccination. ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000186942

    authors: Melappioni M,Baldassari M,Baldini S,Radicioni R,Panichi N

    更新日期:1992-01-01 00:00:00

  • Membranous glomerulonephritis associated with enterococcal endocarditis.

    abstract::An autopsy case of membranous glomerulonephritis associated with enterococcal endocarditis was reported. Although enterococcal antigen was not identified in glomerular deposits, the eluate from the patient's renal tissue was shown to specifically recombine with cells of the enterococcus isolated from his own ante mort...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183435

    authors: Iida H,Mizumura Y,Uraoka T,Takata M,Sugimoto T,Miwa A,Yamagishi T

    更新日期:1985-01-01 00:00:00

  • Bradykinin induces a calcium-store- dependent calcium influx in mouse mesangial cells.

    abstract::Bradykinin (BK) elicits extracellular-dependent [Ca2+](i) elevations in mouse mesangial cells (MMC) that are not blocked by verapamil, nifedipine, L-nicardipine, NiCl(2), or LaCl(3). The aim of the present study was to evaluate the mechanisms involved in calcium influx induced by BK in MMC. [Ca2+](i) was analyzed thro...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000058409

    authors: Campos AH,Calixto JB,Schor N

    更新日期:2002-06-01 00:00:00

  • Characteristic matrix and tubular basement membrane abnormalities in the CBA/Ca-kdkd mouse model of hereditary tubulointerstitial disease.

    abstract::CBA/CaH-kdkd mice develop hereditary tubulointerstitial disease with mononuclear cell infiltration and cyst formation, possibly representing a model of human nephronophthisis. The purpose of the present investigation was to examine the components of the fibrotic changes which typically develop in the kidneys of these ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045191

    authors: Sibalic V,Sun L,Sibalic A,Oertli B,Ritthaler T,Wüthrich RP

    更新日期:1998-11-01 00:00:00