Abstract:
:In order to estimate a regenerative response in the early phase after renal ischemia-reperfusion in rat, we examined the time course of the activation of epidermal growth factor receptor (EGFR) as a response of signal transduction pathway after 45 min ischemia in kidney. The activation of EGFR was observed 5-30 min after the start of reperfusion. Simultaneously, superoxide anion/hydrogen peroxide generated in the mitochondrial fraction was elevated during the same period. On the other hand, the level of EGF decreased in a time-dependent manner. These results suggested that superoxide anion/hydrogen peroxide generated during the ischemia-reperfusion other than EGF could act as an activator for the EGFR. In summary, the activation of EGFR is important as a regenerative response at an early stage after the start of reperfusion in ischemic kidney.
journal_name
Nephronjournal_title
Nephronauthors
Yano T,Yazima S,Hagiwara K,Ozasa H,Ishizuka S,Horikawa Sdoi
10.1159/000045281subject
Has Abstractpub_date
1999-02-01 00:00:00pages
230-3issue
2eissn
1660-8151issn
2235-3186pii
45281journal_volume
81pub_type
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