Urine osmolarity predicts the body weight-reduction response to tolvaptan in chronic kidney disease patients: a retrospective, observational study.

Abstract:

BACKGROUND/AIMS:Tolvaptan, a vasopressin V2 receptor antagonist, promotes the excretion of electrolyte-free water. Patients with heart failure or liver cirrhosis, whose urine osmolarity is high due to increased vasopressin, show a good response to tolvaptan; however, it remains dubious whether tolvaptan is also effective in patients with low urine osmolarity due to decreased renal function. The aim of this study was to investigate whether urine osmolarity predicts the effect of tolvaptan in patients with decreased renal function. METHODS:In this retrospective, observational study, 17 overhydrated chronic kidney disease patients with heart failure or liver cirrhosis who were admitted to Osaka University Hospital were included. They were treated with sodium-excreting diuretics first, and then tolvaptan was added. The clinically relevant parameters were evaluated before and after the use of tolvaptan, and they, including urine osmolarity before use of tolvaptan, were compared between the responder group and the non-responder group. The definition of responder was based on the decrease of body weight by ≥5% in one week, which is a more rigorous indicator of the effectiveness of tolvaptan than the increase in urine output. RESULTS:The parameter that showed a significant difference between the responder and non-responder groups was urine osmolarity before the use of tolvaptan. The cut-off point derived from the receiver operating characteristic (ROC) curve analysis was 279 mOsm/kg H2O, with sensitivity of 0.86 and specificity of 0.80. CONCLUSIONS:In patients with decreased renal function, urine osmolarity before the use of tolvaptan predicted the effectiveness of diuretics in terms of body weight reduction.

journal_name

Nephron

journal_title

Nephron

authors

Iwatani H,Kawabata H,Sakaguchi Y,Yamamoto R,Hamano T,Rakugi H,Isaka Y

doi

10.1159/000381859

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

8-12

issue

1

eissn

1660-8151

issn

2235-3186

pii

000381859

journal_volume

130

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Prolactin status in experimentally induced acute renal failure in the rat.

    abstract::Serum prolactin levels were elevated in male Sprague-Dawley rats with acute renal failure induced by glycerol administration. Specific prolactin binding to kidney membrane preparations was reduced in glycerol and antirat glomerular basement membrane serum-treated rats, after morphological and biochemical acute renal f...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182078

    authors: Dobbie JW,Mountjoy K,Cowden EA,Allison ME,Ratcliffe JG

    更新日期:1981-01-01 00:00:00

  • Studies on abnormal lipid metabolism in experimental nephrotic syndrome.

    abstract::The specific lipid alterations in plasma and four different tissues, as well as the activities of plasma lecithin-cholesterol acyltransferase (LCAT) and tissue lipolytic enzymes were determined in experimental nephrotic and control rats. In nephrotic rats, the cholesterol level in the heart was significantly increased...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187323

    authors: Agbedana ED,Yamamoto T,Moriwaki Y,Suda M,Takahashi S,Higashino K

    更新日期:1993-01-01 00:00:00

  • Accuracy of Acid-Base Diagnoses Using the Central Venous Blood Gas in the Medical Intensive Care Unit.

    abstract:BACKGROUND:Acid-base disturbances are frequent in critically ill patients. Arterial blood gas (ABG) is the gold standard in the diagnosis of these disturbances, but it is invasive with potential hazards. For patients with a central venous catheter, venous blood gas (VBG) sampling may be an alternative, less-invasive di...

    journal_title:Nephron

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000488501

    authors: Schrauben SJ,Negoianu D,Costa C,Cohen RM,Goldfarb S,Fuchs BD,Berns JS

    更新日期:2018-01-01 00:00:00

  • Nephrotoxicity of germanium compounds: report of a case and review of the literature.

    abstract::A 55-year-old woman was admitted to our hospital, complaining of general malaise, muscular weakness, anorexia and weight loss. She had a history of ingesting of a certain germanium (Ge) compound over the preceding 19 months, with a total dose of 47 g as Ge element. She was found to have renal failure (blood urea nitro...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000186805

    authors: Takeuchi A,Yoshizawa N,Oshima S,Kubota T,Oshikawa Y,Akashi Y,Oda T,Niwa H,Imazeki N,Seno A

    更新日期:1992-01-01 00:00:00

  • Urinary kallikrein in normal pregnancy, pregnancy with hypertension, and toxemia.

    abstract::The 24-hour urinary excretion of kallikrein (K) and prostaglandin E2 (PGE2), which reflects their intrarenal synthesis, was measured in 7 normal women (NW), 10 women with essential hypertension (EH), 26 normal pregnant women (NP), 12 women with hypertension in pregnancy (HP), and 4 women with toxemia. All pregnant wom...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183426

    authors: Kovatz S,Arber I,Korzets Z,Rathaus M,Ben Aderet N,Bernheim J

    更新日期:1985-01-01 00:00:00

  • Idiopathic hypercalciuria causing osteoporosis and hypocalcemia.

    abstract::Idiopathic hypercalciuria, though a common cause of nephrolithiasis, has not been recognized to cause hypocalcemia and severe bone disease. We describe an adolescent with idiopathic hypercalciuria who presented initially with severe hypocalcemia and osteoporosis and this was later complicated by recurrent renal calcul...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186878

    authors: Wong CK,Pun KK,Tam SC,Tsui EY,Kung AW,Lam KS,Wang CC

    更新日期:1992-01-01 00:00:00

  • Canine renal and systemic hemodynamic measurements after 4 weeks of a magnesium deficient diet.

    abstract::To probe renal hemodynamic measurements in relation to simultaneous systemic hemodynamic measurements in normal, adult, conscious dogs on a magnesium-deficient diet, 6 experimental animals were given 4 weeks of a magnesium-deficient diet compared to 9 animals whose dietary magnesium was normal. Systemic hemodynamics w...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185169

    authors: Zawada ET Jr,TerWee JA,McClung DE

    更新日期:1988-01-01 00:00:00

  • Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients?

    abstract::Pruritus is a common symptom among patients undergoing long-term hemodialysis. However, its etiology remains unclear. In an attempt to clarify its cause we tried to correlate pruritus and its intensity with several serological variables in 94 hemodialysis patients. Our results show that higher serum aluminum concentra...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189499

    authors: Friga V,Linos A,Linos DA

    更新日期:1997-01-01 00:00:00

  • Safety of Percutaneous Ultrasound-Guided Kidney Biopsy in Patients with AA Amyloidosis.

    abstract:BACKGROUND:Bleeding is the most frequent complication of kidney biopsy. Although bleeding risk in patients with AA amyloidosis after kidney biopsy has not been studied in a large population, AA amyloidosis has long been perceived as a risk factor for bleeding. The aim of the present study was to evaluate post-biopsy bl...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000437443

    authors: Altindal M,Yildirim T,Turkmen E,Unal M,Boga I,Yilmaz R,Arici M,Altun B,Erdem Y

    更新日期:2015-01-01 00:00:00

  • Elevated serum uric acid. A cardiovascular risk factor?

    abstract::A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181660

    authors: Tweeddale MG,Fodor JG

    更新日期:1979-01-01 00:00:00

  • Post-obstruction diuresis: influence of renal prostaglandins.

    abstract::The possible role of altered renal prostaglandin metabolism in the generation of post-obstruction diuresis (POD) was examined in 16 adult male Sprague-Dawley rats. Inhibition of cyclooxygenase by the administration of a combination of two nonsteroidal anti-inflammatory drugs (NSAID), meclofenamate and indomethacin in ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186766

    authors: Kauker ML,Zawada ET

    更新日期:1992-01-01 00:00:00

  • Effect of 1alpha-hydroxycholecalciferol, 1,25-dihydroxycholecalciferol, 3 deoxy-1alpha-hydroxycholecalciferol, 24R, 25-dihydroxycholecalciferol and successful renal transplantation on calcium absorption in haemodialysis patients.

    abstract::Using a 2-hour 47Ca absorption test, significant depression of active calcium absorption was demonstrated in 48 vitamin D untreated haemodialysis patients. This malabsorption of calcium could be corrected by the daily oral administration of 1--2 microgram of 1alphaOHD3 and 1--1.5 microgram of 1,25(OH)2D3. 5 microgram ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181223

    authors: Pierides AM,Aljama P,Kerr DN,Scott M,Norman AW

    更新日期:1978-01-01 00:00:00

  • Mesangial deposition of J chain-linked polymeric IgA in IgA nephropathy.

    abstract::Renal biopsy specimens from 8 patients with IgA nephropathy (Berger's disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the me...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182907

    authors: Komatsu N,Nagura H,Watanabe K,Nomoto Y,Kobayashi K

    更新日期:1983-01-01 00:00:00

  • The effect of converting enzyme inhibition on the enhanced proximal sodium reabsorption induced by chronic diuretic treatment in patients with essential hypertension.

    abstract::During chronic chlorthalidone treatment of patients with essential hypertension, distal tubular sodium reabsorption is continuously inhibited. At the same time, sodium balance is maintained by an increase of the proximal tubular sodium reabsorption. In the present study, we investigated whether this increase is caused...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184485

    authors: van Schaik BA,Geyskes GG,Dorhout Mees EJ

    更新日期:1987-01-01 00:00:00

  • Inhibitor of insulin binding to erythrocytes in plasma of uremic patients.

    abstract::Previously, we have shown that insulin binding (IB) to erythrocytes was decreased in uremic patients and that hemodialysis corrected the receptor defect. In the present study cross-incubation experiments were performed using uremic and control erythrocytes and plasma. Incubation of control erythrocytes with uremic pla...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182990

    authors: Milutinović S,Breyer D,Janković N,Molnar V,Stefović A,Rocić B

    更新日期:1983-01-01 00:00:00

  • Effect of dilazep hydrochlorideon the Im munohistopathology of IgA nephropathy in ddY mice.

    abstract::We determined the clinical and immunopathological effects of dilazep hydrochloride (dilazep) on IgA nephropathy of ddY mice. Group I (early-treatment group, n = 10) was orally treated with 300 mg/kg body weight of this drug from 12 weeks of age until 60 weeks of age, and group II (late-treatment group, n = 10) was als...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045788

    authors: Hayashi T,Kaneko S,Thang NT,Shou I,Shirato I,Tomino Y

    更新日期:2000-11-01 00:00:00

  • Effects of incubation at various 'room' temperatures on the sensitivity and specificity of Microstix-3.

    abstract::The feasibility of room temperature incubation of Microstix-3 specimens to detect urinary tract infection was studied. This procedure, if successful, would allow home monitoring of patients and eliminate the need for an incubator. Four Microstix-3 strips were dipped into each of 1,241 urine specimens and incubated at ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182640

    authors: Akriotis VJ,Arbus GS

    更新日期:1982-01-01 00:00:00

  • Combined chemotherapy and radiotherapy for esophageal carcinoma in a hemodialyzed patient. Long-term survival.

    abstract::The use of antimitotic chemotherapy in hemodialysis patients is not yet well codified, and each individual decision remains difficult. We report the case of a 68-year-old hemodialyzed man who developed a squamous cell carcinoma of the upper third of the esophagus. Necessarily disabling surgery was rejected, and three ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189461

    authors: Rebibou JM,Chauffert B,Dumas M,Mousson C,Bone MC,Tanter Y,Rifle G

    更新日期:1996-01-01 00:00:00

  • Exaggerated glomerular albuminuria after cobra venom factor in anti-glomerular basement membrane disease.

    abstract::The mechanisms by which intercurrent bacterial infections are associated with increased tissue injury in some forms of glomerulonephritis may include complement activation by bacteria and subsequent increased glomerular neutrophil (PMN) infiltration. We have studied the effect of complement activation after cobra veno...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185578

    authors: Savige JA,Dash AC,Rees AJ

    更新日期:1989-01-01 00:00:00

  • Effects of furosemide on renal oxygen consumption after ischemia in normal and streptozotocin diabetic rats.

    abstract::Normal and streptozotocin diabetic rats were subjected to ischemic injury by unilateral renal artery occlusion for 60 min. The cortical and the medullary oxygen consumption (QO2) in the postischemic and the control, contralateral nonischemic, kidneys were measured 1 h, 1 day, and 1, 2 and 4 weeks for normal rats and 1...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187367

    authors: Kuramochi G,Homma S

    更新日期:1993-01-01 00:00:00

  • Outcomes of Elderly Patients with Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis Treated with Immunosuppressive Therapy.

    abstract:BACKGROUND/AIMS:Anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is a cause of biopsy-proven acute kidney injury, more common in the elderly. Treatment requires immunosuppression, which can have significant toxic effects. The aim of this study was to assess whether morbidity and mortality that are a...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000447018

    authors: Judge PK,Reschen ME,Haynes R,Sharples EJ

    更新日期:2016-01-01 00:00:00

  • Bradykinin induces a calcium-store- dependent calcium influx in mouse mesangial cells.

    abstract::Bradykinin (BK) elicits extracellular-dependent [Ca2+](i) elevations in mouse mesangial cells (MMC) that are not blocked by verapamil, nifedipine, L-nicardipine, NiCl(2), or LaCl(3). The aim of the present study was to evaluate the mechanisms involved in calcium influx induced by BK in MMC. [Ca2+](i) was analyzed thro...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000058409

    authors: Campos AH,Calixto JB,Schor N

    更新日期:2002-06-01 00:00:00

  • A rare cause of pulmonary-renal syndrome.

    abstract::Diseases affecting both the lung and the kidney have grave prognosis and serious diagnostic and therapeutic consequences. Here, 3 cases of pulmonary-renal syndrome caused by antiphospholipid syndrome are reported. The patients presented with dyspnea, renal insufficiency, pulmonary infiltrates on chest X-ray and areas ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064300

    authors: Henning BF,Gröne HJ,Tepel M,Büchner N,Kirchner J,Zidek W

    更新日期:2002-07-01 00:00:00

  • A blind controlled trial of phase-contrast microscopy by two observers for evaluating the source of haematuria.

    abstract::Two observers, unaware of each other's findings and of the diagnosis, examined red cells in the urine of 109 patients by phase-contrast microscopy. All specimens were examined uncentrifuged by inverted microscopy, and 48 of the 109 were also examined under a light microscope after centrifugation. We were unable to con...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000184011

    authors: Venkat Raman G,Pead L,Lee HA,Maskell R

    更新日期:1986-01-01 00:00:00

  • C1Q complexes with beta-2-microglobulin and amyloid P-component in sera of patients with dialysis-associated amyloidosis.

    abstract::We studied complexes composed of C1q and beta 2-microglobulin (C1q.beta 2M) or serum amyloid P-component (C1q.SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-as...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188506

    authors: Hasegawa M,Kawashima S,Shikano M,Kojima K,Yanai T,Hassegawa H,Tomita M,Murakami K,Kawamura N,Katsumata H

    更新日期:1995-01-01 00:00:00

  • A new kindred with hereditary hypophosphatemic rickets with hypercalciuria: implications for correct diagnosis and treatment.

    abstract::Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a new autosomal form of hypophosphatemic rickets, recently described. This disease is characterized, and differs from other forms of hereditary hypophosphatemic rickets and/or osteomalacia by increased serum levels of 1,25-dihydroxyvitamin D, hypercalci...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187029

    authors: Tieder M,Arie R,Bab I,Maor J,Liberman UA

    更新日期:1992-01-01 00:00:00

  • Failure to reduce cholesterol as explanation for the limited efficacy of antihypertensive treatment in the reduction of coronary heart disease. Evidence from the Hypertension Detection and Follow-up program (1973-1979).

    abstract::The recent experience of six large trials of antihypertensive therapy has not clearly demonstrated any beneficial effect on the prevention of coronary heart disease (CHD). The data from the HDFP study have been analyzed by three cholesterol strata at baseline. The higher the baseline cholesterol levels, the greater th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184564

    authors: Schneider KA,Heyden S,Ford C

    更新日期:1987-01-01 00:00:00

  • Stimulation of polymorphonuclear leukocyte chemotaxis by cold precipitable complexes containing DNA-anti-DNA in active nephritis of systemic lupus erythematosus.

    abstract::DNA-anti-DNA cold precipitable complexes (CPC) isolated from 21 patients with systemic lupus erythematosus were tested for their ability to stimulate polymorphonuclear leukocyte (PMN) chemotaxis and to activate complement in vitro. The complexes activated complement in 20 out of 21 cases and stimulated PMN chemotaxis ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182509

    authors: Losito A,Cecchini C,Pittavini L,Zampi I

    更新日期:1982-01-01 00:00:00

  • Glycogen synthesis from serine in isolated perfused hindquarters of acutely uraemic rats.

    abstract::Isolated hindquarters of bilaterally nephrectomized and sham-operated rats were perfused in the presence and absence of 14C-labelled serine, respectively. After a perfusion period of 30 min 14C-serine was 4,074 +/- 270 dpm/ml in the perfusion medium of sham-operated animals and decreased to 2,800 +/- 190 dpm/ml in the...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183003

    authors: Djovkar A,Hörl WH,Heidland A

    更新日期:1983-01-01 00:00:00

  • Increased clearance rate of prednisone in the isolated perfused liver of uremic rats.

    abstract::The effect of uremia upon the hepatic clearance rate of prednisone was studied in isolated perfused livers of normal and uremic female rats. The perfusion rate was kept at a constant flow rate of 25 ml/min. In order to induce uremia, one group of rats was 5/6 nephrectomized 3 weeks prior to the perfusions. The concent...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184072

    authors: Egfjord W,Langhoff E,Daugaard H,Olgaard K

    更新日期:1987-01-01 00:00:00