Abstract:
:Serum prolactin levels were elevated in male Sprague-Dawley rats with acute renal failure induced by glycerol administration. Specific prolactin binding to kidney membrane preparations was reduced in glycerol and antirat glomerular basement membrane serum-treated rats, after morphological and biochemical acute renal failure was evident. Extensive tubular damage after glycerol administration may account for loss of renal binding, since prolactin receptors are mainly tubular in localization. However, the predominant glomerulopathy, with less severe tubular lesions, after antirat glomerular basement membrane serum suggests that reduced renal prolactin binding in these animals is unlikely to be due to tubular destruction alone. Thus, alterations in prolactin status occur with development of experimentally induced acute renal failure and suggest altered renal responsiveness to prolactin in uraemia.
journal_name
Nephronjournal_title
Nephronauthors
Dobbie JW,Mountjoy K,Cowden EA,Allison ME,Ratcliffe JGdoi
10.1159/000182078subject
Has Abstractpub_date
1981-01-01 00:00:00pages
316-9issue
6eissn
1660-8151issn
2235-3186journal_volume
27pub_type
杂志文章相关文献
NEPHRON文献大全abstract::A 45-year-old male was admitted to the hospital because of polyuria and polydipsia. After admission, proteinuria and hematuria were found. The kidney function deteriorated and necessitated the initiation of chronic hemodialysis. Examination of the bone marrow revealed multiple myeloma and kappa light chains were found...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182980
更新日期:1983-01-01 00:00:00
abstract::Diabetic nephropathy is the leading cause of kidney failure. Treatments with drugs that block the renin-angiotensin system have proven beneficial in slowing kidney disease progression among those with diabetes; their benefit is limited and they do not stop disease progression. Despite multiple clinical trials of vario...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000450895
更新日期:2017-01-01 00:00:00
abstract::Chromoblastomycosis is a rare, deep mycosis seen mostly in tropical and subtropical regions. We have encountered a kidney transplant recipient with this subcutaneous mycosis developing as an asymptomatic mass in the right forearm. The lesion recurred after an initial local excision, but it is now apparently cured 10 m...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183468
更新日期:1985-01-01 00:00:00
abstract::During hemodialysis, platelets are activated across a dialyzer. Soluble P-selectin (sP-selectin) is a form of P-selectin which is a glycoprotein relocated from secretory granules to the surfaces of platelets and endothelial cells after these cells have been physiologically activated. To investigate whether sP-selectin...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044903
更新日期:1998-01-01 00:00:00
abstract::In normal subjects, the gastric ionisation of calcium and phosphate seems to be a prerequisite for their intestinal absorption. We investigated the behavior of the plasma calcium and phosphate profile in 30 patients on regular dialysis treatment in the 6 h following a meal containing 1 g of calcium and 2 g of phosphat...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064290
更新日期:2002-07-01 00:00:00
abstract::The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046096
更新日期:2001-11-01 00:00:00
abstract::This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insuffic...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044888
更新日期:1998-01-01 00:00:00
abstract::Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent fo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000450862
更新日期:2017-01-01 00:00:00
abstract::DNA-anti-DNA cold precipitable complexes (CPC) isolated from 21 patients with systemic lupus erythematosus were tested for their ability to stimulate polymorphonuclear leukocyte (PMN) chemotaxis and to activate complement in vitro. The complexes activated complement in 20 out of 21 cases and stimulated PMN chemotaxis ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182509
更新日期:1982-01-01 00:00:00
abstract::ExHC rats were bred from the Sprague-Dawley strain and are highly susceptible to dietary hypercholesterolemic stimuli. Although chemical and histological examination of the aorta from ExHC rats fed a diet containing 3% cholesterol, 0.6% sodium cholate and 15% olive oil (high-cholesterol diet, HCD) has been reported, r...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187216
更新日期:1993-01-01 00:00:00
abstract::5 cases of severe acute renal failure caused by ethyl alcohol-induced rhabdomyolysis are reviewed. 4 patients were dialyzed. All patients recovered completely from the renal failure. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183151
更新日期:1984-01-01 00:00:00
abstract::The cytoprotective effect of ulinastatin was studied in LLC-PK1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release of lactate dehydrogenase and a decrease in the amount of remaining protein. In the cell injury models treated with ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000190195
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:Alterations to the procurement biopsy are one of the main reasons that kidneys are not suitable for transplant and are discarded. The literature on procurement and reperfusion biopsy is inconsistent and heterogeneous. The objective of this study is to describe the correlation of the different histological ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000513120
更新日期:2021-01-28 00:00:00
abstract::The effect of changes in the dialysate calcium concentration on calcium fractions and parathyroid hormone species in plasma during hemodialysis has been examined. C-terminal immunoreactive parathyroid hormone was suppressed when plasma calcium increased by greater than 25% whereas N-terminal fragments demonstrated an ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180870
更新日期:1977-01-01 00:00:00
abstract::The present study was aimed to determine the effect of caffeine on the development of renal hypertension. Two-kidney, 1-clip (2K1C) hypertension and deoxycorticosterone acetate (DOCA, 200 mg/kg, subcutaneous implantation)-salt (0.9% NaCl drinking) hypertension were instituted in Sprague-Dawley rats. They were then gro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187574
更新日期:1993-01-01 00:00:00
abstract::The size distribution pattern of circulating rPRL was studied in intact control (C) rats and in three uremic models, namely urine autoinfusion (UA), bilateral ureteral ligation (BUL), and bilateral nephrectomy (BNx). Plasmas were chromatographed by gel filtration in Sephadex G-100. Rat PRL was measured by RIA. The rPR...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183306
更新日期:1984-01-01 00:00:00
abstract::The fall in white blood cells (WBC) and arterial oxygen pressure that occurs during hemodialysis was investigated as a function of different dialysis membranes and different sterilization methods. 8 chronic hemodialysis patients were studied and each was dialyzed with three different membranes: cellulosic hollow fiber...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182728
更新日期:1982-01-01 00:00:00
abstract::Plasma levels of granulocyte lactoferrin, granulocyte myeloperoxidase and granulocyte elastase in complex with alpha 1-proteinase inhibitor were investigated during hemodialysis in oliguric patients following cadaveric renal transplantation (CRT). The results were compared with those of patients undergoing regular hem...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184333
更新日期:1987-01-01 00:00:00
abstract::Thrombospondin (TSP) is a multifunctional glycoprotein that is synthesized by a variety of cells including mesangial cells (MCs). To clarify the effect of TSP on the pathogenesis of diabetic nephropathy, we studied the effect of glucose concentrations on TSP synthesis in cultured human MCs. Thereafter, the effects of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044989
更新日期:1998-01-01 00:00:00
abstract::A case of a renal transplant recipient with colchicine-induced myopathy is presented. He was on colchicine therapy for 10 months. He was hospitalized for investigation of fatigue, severe myalgia in the lower extremities and elevated serum aminotransferase levels. His viral markers and other factors that may cause myal...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000065439
更新日期:2002-12-01 00:00:00
abstract::Chronic renal failure induces anemia and a short erythrocyte life span. Red blood cell (RBC) osmotic fragility is the resistance of RBC hemolysis to osmotic changes that is used to evaluate RBC friability. To find the cause of shortened red cell survival in uremic patients, we evaluated the RBC osmotic fragility in 57...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000044878
更新日期:1998-01-01 00:00:00
abstract::Increased free-radical production leading to oxidative stress may contribute to the development of cardiovascular complications in haemodialysis patients. The ferroxidase activity of caeruloplasmin forms an important component of antioxidant defences in body fluids. The aim of this study was to assess ferroxidase acti...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045579
更新日期:2000-03-01 00:00:00
abstract:INTRODUCTION/AIMS:The Acute Kidney Injury Network classification is based on small increases in serum creatinine (sCr) for stage 1. This study investigated whether changes in the urinary concentration of neutrophil gelatinase-associated lipocalin (uNGAL) could predict small increases in sCr in patients undergoing coron...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000368413
更新日期:2015-01-01 00:00:00
abstract::Hypercalciuria and nephrocalcinosis are not uncommon in patients with Wilson's disease but have only once been reported as the presenting sign. We diagnosed Wilson's disease in a 17-year-old male patient 6 years after his first episode of gross hematuria and 2 years after detection of hypercalciuria and nephrocalcinos...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187530
更新日期:1993-01-01 00:00:00
abstract::Sickle cell nephropathy characterized by proteinuria and predominantly glomerular lesions has not been studied as extensively as renal tubular alterations in sickle cell disease. We reviewed our experience with this entity over a 14-year period. Of 13 children with either proteinuria or the nephrotic syndrome, 8 showe...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183404
更新日期:1985-01-01 00:00:00
abstract::The clinical profile of a patient with a 15 years' evolution of acne conglobata developing systemic amyloidosis with severe renal involvement is described, and the possible influence of suppurative skin foci surgical excision on the rapid progression to terminal renal failure is discussed. This etiological cause of se...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186227
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often difficult to treat. However, the factors influencing cyst infection are still unknown. Therefore, we investigated clinical factors related to the duration of hospitalization and death d...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000493806
更新日期:2019-01-01 00:00:00
abstract::The concentration of ionic calcium (Ca2+ in the smooth muscular cells of the resistance vessels is a determining factor of their contraction. It depends on the influx of Ca2+ to the interior of the cells through the calcium channels in the sarcolemma. The effect of a specific Ca2+-channel blocking agent - nifedipine -...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183607
更新日期:1985-01-01 00:00:00
abstract::The protective efficacy of three schedules of a recombinant hepatitis B vaccine was evaluated in 42 patients undergoing dialysis at a teaching hospital. The rate of seroconversion after vaccination was highest (82.3%) among the recipients of three 20-micrograms doses (i.e. double the conventional dose for healthy adul...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000189103
更新日期:1996-01-01 00:00:00
abstract::Serum and urinary concentrations of NCl, the non collagenous globular domain of collagen IV, were used as markers for turnover of basement membranes. NCl levels were studied in membranous glomerulonephritis and diabetic nephropathy. Thirteen patients with membranous glomerulonephritis and 8 insulin-dependent diabetic ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186511
更新日期:1991-01-01 00:00:00