Prolactin status in experimentally induced acute renal failure in the rat.

Abstract:

:Serum prolactin levels were elevated in male Sprague-Dawley rats with acute renal failure induced by glycerol administration. Specific prolactin binding to kidney membrane preparations was reduced in glycerol and antirat glomerular basement membrane serum-treated rats, after morphological and biochemical acute renal failure was evident. Extensive tubular damage after glycerol administration may account for loss of renal binding, since prolactin receptors are mainly tubular in localization. However, the predominant glomerulopathy, with less severe tubular lesions, after antirat glomerular basement membrane serum suggests that reduced renal prolactin binding in these animals is unlikely to be due to tubular destruction alone. Thus, alterations in prolactin status occur with development of experimentally induced acute renal failure and suggest altered renal responsiveness to prolactin in uraemia.

journal_name

Nephron

journal_title

Nephron

authors

Dobbie JW,Mountjoy K,Cowden EA,Allison ME,Ratcliffe JG

doi

10.1159/000182078

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

316-9

issue

6

eissn

1660-8151

issn

2235-3186

journal_volume

27

pub_type

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