Abstract:
:We report a case of rapidly progressive glomerulonephritis due to antiglomerular basement membrane (anti-GBM) antibodies that progressed to end-stage renal disease in a 35-year-old man who used intranasal cocaine on an occasional basis. In contrast to many prior reports of acute renal failure occurring with cocaine-associated rhabdomyolysis, this patient did not have any evidence of acute muscle damage and myoglobin release. Circulating anti-GBM antibodies and renal biopsy with linear IgG and C3 deposits confirmed the diagnosis of anti-GBM disease. The possibility of anti-GBM must be considered in the differential diagnosis of acute renal failure in cocaine addicts. This unusual combination raises complex questions regarding the pathogenesis of this type of renal injury.
journal_name
Nephronjournal_title
Nephronauthors
Peces R,Navascués RA,Baltar J,Seco M,Alvarez Jdoi
10.1159/000045328subject
Has Abstractpub_date
1999-01-01 00:00:00pages
434-8issue
4eissn
1660-8151issn
2235-3186pii
45328journal_volume
81pub_type
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