Estimation of statistical moments for desferrioxamine and its iron and aluminum chelates: contribution to optimisation of therapy in uremic patients.

Abstract:

:We investigated the best time of administration of desferrioxamine (DFO) with respect to the dialysis session, using the approach of the stochastic dynamic system, integrated with the classical pharmacokinetic models. In the 6 patients studied, the mean arrival times of DFO, aluminoxamine (AlO) and ferrioxamine (FO) were, respectively, 193, 1,350 and 126 min, the mean residence times were 1,048, infinite, 1,190 min, respectively. AlO serum levels reach steady state in a mean time of 7 h and 22 min and remain stable in the interdialytic period. FO achieves a peak at the end of DFO infusion and declines during the interdialytic period. DFO, AlO and FO persist a very long time in the body of the uremic patient, thus the dialysis session should be administered when AlO and FO reach steady state. With a dose of 5-10 mg/kg b.w. of DFO, we propose to start the dialysis 8-12 h after the infusion if the main purpose is to treat Al overload or 2-3 h after the infusion if the main purpose is the treatment of hemosiderosis.

journal_name

Nephron

journal_title

Nephron

authors

Andriani M,Nordio M,Saporiti E

doi

10.1159/000188845

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

218-24

issue

2

eissn

1660-8151

issn

2235-3186

journal_volume

72

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Idiopathic hypercalciuria causing osteoporosis and hypocalcemia.

    abstract::Idiopathic hypercalciuria, though a common cause of nephrolithiasis, has not been recognized to cause hypocalcemia and severe bone disease. We describe an adolescent with idiopathic hypercalciuria who presented initially with severe hypocalcemia and osteoporosis and this was later complicated by recurrent renal calcul...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186878

    authors: Wong CK,Pun KK,Tam SC,Tsui EY,Kung AW,Lam KS,Wang CC

    更新日期:1992-01-01 00:00:00

  • Plasma levels of main granulocyte components during hemodialysis: effects of immunosuppression.

    abstract::Plasma levels of granulocyte lactoferrin, granulocyte myeloperoxidase and granulocyte elastase in complex with alpha 1-proteinase inhibitor were investigated during hemodialysis in oliguric patients following cadaveric renal transplantation (CRT). The results were compared with those of patients undergoing regular hem...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184333

    authors: Riegel W,Leverenz K,Schollmeyer P,Wilms H,Hörl WH

    更新日期:1987-01-01 00:00:00

  • Serial studies of the renin system in rats with glycerol-induced renal failure.

    abstract::Serial changes in plasma of renin concentration (PRC), renin-substrate concentration (PSC) and renin activity (PRA) were followed in rats during glycerol-induced acute renal failure. There was an early but transient increase in PRC and a more delayed and prolonged rise in PSC. PRA began to rise a few hours after glyce...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181196

    authors: Carvalho JS,Page LB

    更新日期:1978-01-01 00:00:00

  • Differential changes of cell cycle regulators and activities in kidneys during pre- and postnatal development.

    abstract::The present study was designed to determine the changes of the cyclin/CDK (cyclin dependent kinase)/CKI (CDK inhibitors) system in kidneys during pre- and postnatal development. All protein levels of cyclins (cyclins D1, D3, E, A, B) and protein levels and activities of CDKs (CDK4, CDK2, cdc2) were high in kidneys dur...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045302

    authors: Park SK,Kim W,Lee H,Lee DY,Koh GY

    更新日期:1999-01-01 00:00:00

  • A new technique for insertion of the Tenckhoff peritoneal dialysis catheter.

    abstract::To eliminate the discomfort caused by surgical methods and the risks involved using the trocar, for 1 year we have been using a new technique for insertion of peritoneal catheters (PC). We devised a steel instrument, vaguely resembling a rhinoscope, composed of two semicones. The handles are connected by a screw to pe...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183526

    authors: Di Paolo N,Manganelli A,Strappaveccia F,De Mia M,Gaggiotti E

    更新日期:1985-01-01 00:00:00

  • Analysis of urinary albumin excretion in gentamicin-treated rats.

    abstract::Gentamicin doses of 40 mg/kg body weight/day were administered intravenously to 62 Wistar rats. Nineteen animals were also treated orally with an NaHCO3 solution in place of water. The gentamicin-treated animals showed increased albuminuria immediately after the 3rd day of treatment. The fact that this increase was ma...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185043

    authors: Coimbra TM,Lachat JJ

    更新日期:1988-01-01 00:00:00

  • Polyarteritis nodosa and necrotizing glomerulonephritis associated with long-standing silicosis.

    abstract::A 55-year-old white male, with silicosis diagnosed 10 years earlier, presented massive proteinuria with microscopic hematuria, moderate renal failure and distal polyneuropathy. Bilateral renal angiography showed multiple intraparenchymal saccular aneurysms. Renal biopsy disclosed a focal segmental necrotizing glomerul...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185391

    authors: Arnalich F,Lahoz C,Picazo ML,Monereo A,Arribas JR,Martínez Ara J,Vázquez JJ

    更新日期:1989-01-01 00:00:00

  • Uremic pruritus and skin mast cells.

    abstract::The number of mast cells in the skin was evaluated in 25 patients with end-stage renal failure on different treatment modality (conservative, hemodialysis and peritoneal dialysis). According to the presence of pruritus, uremic patients were divided into two groups: group A, 13 patients with diffuse pruritus, and group...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186826

    authors: Dimković N,Djukanović L,Radmilović A,Bojić P,Juloski T

    更新日期:1992-01-01 00:00:00

  • Assessment of the length of each hemodialysis session by on-line dialysate urea monitoring.

    abstract::Hemodialysis (HD) prescription is usually based on the periodical measurement of the Kt/V achieved in a midweek dialysis session. The purpose of the study was to assess the duration of each HD session to achieve a target dose of dialysis. This allowed to determine whether a given dialysis session may be considered rep...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000046041

    authors: Hernandez-Herrera G,Martin-Malo A,Rodriguez M,Aljama P

    更新日期:2001-09-01 00:00:00

  • Platelet-activating factor levels and PAF acetylhydrolase activities in patients with primary glomerulonephritis.

    abstract::Platelet-activating factor (PAF) belongs to a new class of lipid chemical inflammatory mediators described as acetyl glyceryl ether phosphorylcholine. Although PAF has been implicated in kidney injury, its role in renal immune injury has not been clearly defined yet. We studied the levels of PAF in the plasma and urin...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000188948

    authors: Iatrou C,Moustakas G,Antonopoulou S,Demopoulos CA,Ziroyiannis P

    更新日期:1996-01-01 00:00:00

  • Risks of Metformin in Type 2 Diabetes and Chronic Kidney Disease: Lessons Learned from Taiwanese Data.

    abstract::Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent fo...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000450862

    authors: Rhee CM,Kovesdy CP,Kalantar-Zadeh K

    更新日期:2017-01-01 00:00:00

  • Changes in plasma atrial natriuretic factor during sequential fluid removal and biochemical correction in end-stage chronic renal failure patients.

    abstract::Plasma immunoreactive atrial natriuretic factor (ANF) levels, their chromatographic profiles (high-performance liquid chromatography; HPLC) and changes during sequential ultrafiltration (UF; 1 litre/h) and biochemical correction without fluid removal (BC; 3 h) were studied in 8 end-stage chronic renal failure patients...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000185919

    authors: Tonolo G,McMillan M,Richards AM,Montorsi P,Polonia J,Soro A,Troffa C,Glorioso N

    更新日期:1990-01-01 00:00:00

  • Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade.

    abstract::Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, ...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000507305

    authors: Perico L,Benigni A,Remuzzi G

    更新日期:2020-01-01 00:00:00

  • Potassium depletion potentiates amphotericin-B-induced toxicity to renal tubules.

    abstract::Hypokalemia and potassium depletion are frequent complications of amphotericin B therapy. Both ischemic and gentamicin-induced renal failure is potentiated by potassium depletion; it is, therefore, possible that amphotericin B nephrotoxicity is similarly influenced. This study evaluated whether the acute nephrotoxic r...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188590

    authors: Bernardo JF,Murakami S,Branch RA,Sabra R

    更新日期:1995-01-01 00:00:00

  • Successful control of hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis using magnesium carbonate and calcium carbonate as phosphate binders.

    abstract::To avoid the use of aluminium as a phosphate binder, patients on CAPD who were stable were dialysed against a peritoneal dialysis fluid which was magnesium free. A mixture of calcium and magnesium carbonate was used as a phosphate binder over a period in excess of 1 year. Vitamin D analogues were used in the majority....

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187238

    authors: Parsons V,Baldwin D,Moniz C,Marsden J,Ball E,Rifkin I

    更新日期:1993-01-01 00:00:00

  • Acquired type II protein C deficiency in a long-term hemodialysis patient.

    abstract::We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreas...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187835

    authors: Maruyama H,Gejyo F,Hanano M,Arakawa M

    更新日期:1994-01-01 00:00:00

  • Alterations of arterial function in end-stage renal disease.

    abstract::Cardiovascular disease is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Epidemiological and clinical studies have shown that this is most frequently related to damage of large conduit arteries. Macrovascular disease develops rapidly in uremic patients and is responsible for ...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000045557

    authors: London GM

    更新日期:2000-02-01 00:00:00

  • Urinary angiotensin II: a marker of renal tissue activity?

    abstract::The methodology for the collection, extraction, separation and measurement of urinary angiotensin II [the octapeptide, ANG(1-8)] is described. To determine the origin of urinary ANG(1-8), mean arterial pressure, renal hemodynamics and the arterial, renal venous and urinary concentrations of ANG(1-8) were examined prio...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000188215

    authors: Reams G,Villarreal D,Wu Z,Bauer JH

    更新日期:1994-01-01 00:00:00

  • Decreased serum antioxidant activity of hemodialysis patients demonstrated by methylguanidine synthesis and microsomal lipid peroxidation.

    abstract::This study aims to raise the possibility of methylguanidine, a peroxidative product of creatinine, as a measure of the peroxidative state. As a known standard, we measured the inhibitory effect of uremic serum on the NADPH-dependent microsomal lipid peroxidation. This is an established method for evaluating the peroxi...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189451

    authors: Nagase S,Aoyagi K,Hirayama A,Gotoh M,Ueda A,Tomida C,Kikuchi H,Takemura K,Koyama A

    更新日期:1996-01-01 00:00:00

  • Effects of dietary protein on uranyl-nitrate-induced acute renal failure.

    abstract::The effects of dietary protein both before and after uranyl-nitrate-induced acute renal failure were investigated. Male Sprague-Dawley rats were maintained on high-protein (60%), normal-protein (20%), low-protein (5%) and no-protein diets for 8 days prior to intravenous administration of uranyl nitrate (10 mg/kg). Imm...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184167

    authors: Andrews PM,Bates SB

    更新日期:1987-01-01 00:00:00

  • Exercise capacity in hemodialysis, CAPD, and renal transplant patients.

    abstract::Eighteen hemodialysis, 12 chronic ambulatory peritoneal dialysis (CAPD), and 20 renal transplant patients performed maximal treadmill exercise tests. Heart rates and blood pressures were determined every minute and maximal oxygen consumption was measured directly. Exercise capacity as measured by VO2 max is low in dia...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183632

    authors: Painter P,Messer-Rehak D,Hanson P,Zimmerman SW,Glass NR

    更新日期:1986-01-01 00:00:00

  • Renal involvement in acro-renal-ocular syndrome: interstitial nephritis, unlikely pyelonephritis.

    abstract::We describe a case, seemingly sporadic, in which ocular and acral malformations were associated with an interstitial nephropathy; we made a diagnosis of acro-renal-ocular syndrome. There was no stasis, reflux, or urinary tract infection in our patient. We believe that interstitial nephritis in acro-renal-ocular syndro...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187896

    authors: Boscutti G,Pizzolitto S,Montanaro D,Messa P,Messa M,Favazza A,Beltrami CA,Mioni G

    更新日期:1994-01-01 00:00:00

  • Late-onset cytomegalovirus-associated interstitial nephritis in a kidney transplant.

    abstract::Cytomegalovirus is the most important viral infection in kidney transplants, but rarely affects the allograft after the sixth month posttransplantation. We present a patient who developed renal failure eighteen months posttransplant; a kidney biopsy showed cytomegalovirus inclusions, acute tubular necrosis and mild in...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000063316

    authors: Trimarchi H,Jordan R,Iotti A,Forrester M,Iotti R,Freixas E,Martínez J,Schropp J,Pereyra H,Efrón E

    更新日期:2002-10-01 00:00:00

  • Altered interleukin-1 production in patients undergoing hemodialysis.

    abstract::The capacity of peripheral blood mononuclear cells (PBMC) to undergo spontaneous and induced interleukin-1 (IL-1) production was examined in 10 healthy controls and in 10 patients undergoing intermittent hemodialysis (HD) using cuprophane membranes. Extracellular and cytoplasmic IL-1 activity was assayed by biologic a...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185187

    authors: Blumenstein M,Schmidt B,Ward RA,Ziegler-Heitbrock HW,Gurland HJ

    更新日期:1988-01-01 00:00:00

  • Impaired intestinal absorption of riboflavin in experimental uremia.

    abstract::Increased plasma and red blood cell concentrations of riboflavin have been reported in uremia. The possible role of altered intestinal absorption of riboflavin in the genesis of this abnormality is not known. For this reason we examined the intestinal absorption of riboflavin in rats made uremic by subtotal nephrectom...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183541

    authors: Vaziri ND,Said HM,Hollander D,Barbari A,Patel N,Dang D,Kariger R

    更新日期:1985-01-01 00:00:00

  • Effect of hemodialysis on plasma levels of vasoactive peptides: endothelin, calcitonin gene-related peptide and human atrial natriuretic peptide.

    abstract::To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in pla...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187399

    authors: Niwa T,Fujishiro T,Uema K,Tsuzuki T,Tominaga Y,Emoto Y,Miyazaki T,Maeda K

    更新日期:1993-01-01 00:00:00

  • IgA nephropathy. Evaluation of prognostic factors in patients with moderate disease.

    abstract::Previous studies of IgA nephropathy have demonstrated a number of prognostically significant clinical and pathological factors in groups of patients with the full histological spectrum of the disease. Whether these factors can be applied to a group of IgA nephropathy patients with disease of moderate degree is unknown...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184518

    authors: Magil AB,Ballon HS

    更新日期:1987-01-01 00:00:00

  • Urinary complement factor H in renal disease.

    abstract:BACKGROUND:Complement factor H (hCFH) plays a key inhibitory role in the control of the alternative complement pathway. We examined whether urinary hCFH (U-hCFH) levels is useful as an indirect indicator of renal damage. METHODS:Urine samples were obtained from 104 patients with renal disease. Urine was collected with...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064090

    authors: Tamano M,Fuke Y,Endo M,Ohsawa I,Fujita T,Ohi H

    更新日期:2002-01-01 00:00:00

  • Nephropathy and mixed cryoglobulinemia: evidence for an immune complex pathogenesis.

    abstract::Mixed IgM-IgG cryoglobulins were present in the serum of a patient with the nephrotic syndrome, recurrent purpura, chronic active hepatitis and ascites. A renal biopsy demonstrated deposition of IgM, IgG, and complement components C3 and C4 in intracapillary 'coagula' and glomerular capillary walls. No glomerular depo...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180591

    authors: Zimmerman SW,Dreher WH,Burkholder PM,Goldfarb S,Weinstein AB

    更新日期:1976-01-01 00:00:00

  • The FENa test is of no prognostic value in acute renal failure.

    abstract::A 2-year prospective study was done in 45 patients to see whether the FENa test, done at first nephrology consultation visit for acute renal failure, was useful in prognosticating whether patients would recover renal function spontaneously or need dialysis. Of 26 patients who recovered renal function spontaneously, 8 ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183110

    authors: Pru C,Kjellstrand CM

    更新日期:1984-01-01 00:00:00