Abstract:
BACKGROUND:Complement factor H (hCFH) plays a key inhibitory role in the control of the alternative complement pathway. We examined whether urinary hCFH (U-hCFH) levels is useful as an indirect indicator of renal damage. METHODS:Urine samples were obtained from 104 patients with renal disease. Urine was collected with 10 mM EDTA and U-hCFH levels were measured using the BTA TRAK Assay Kit. RESULTS:In the 62 patients with nephritis, the levels of U-hCFH were elevated (range 15-52,198 U/ml) over the normal range (0-14 U/ml). U-hCFH levels of patients with chronic renal failure, lupus nephritis, membranoproliferative glomerulonephritis, focal glomerulosclerosis were higher than that of IgA nephropathy patients (p < 0.05). In the patients with minimal change disease, showed high levels of U-hCFH during the nephrotic syndrome. U-hCFH was correlated significantly with urinary protein and urinary N-acetyl-beta-D-glucosaminidase. CONCLUSIONS:We demonstrated that U-hCFH was detected in the urine of nephritis patients.
journal_name
Nephronjournal_title
Nephronauthors
Tamano M,Fuke Y,Endo M,Ohsawa I,Fujita T,Ohi Hdoi
10.1159/000064090subject
Has Abstractpub_date
2002-01-01 00:00:00pages
705-7issue
3eissn
1660-8151issn
2235-3186pii
64090journal_volume
92pub_type
杂志文章相关文献
NEPHRON文献大全abstract::There is already a considerable amount of evidence suggesting that fibronectin (Fn) plays an important role in the pathogenic process in some forms of glomerulonephritis (GN). It has been postulated that Fn may participate in the progression or regression of glomerular diseases. The Fn is presented in the kidney as a ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187249
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND/AIMS:Albuminuria is a risk factor for coronary artery calcification (CAC) and cardiovascular disease (CVD). Although the urine dipstick test is widely used to screen albuminuria, little is known about the association between low-grade urine dipstick albumin and CAC. The aim of this study is to investigate th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000490954
更新日期:2018-01-01 00:00:00
abstract::Clearance and in vitro microperfusion studies were performed in rabbits to determine the effect of cisplatin on proximal straight tubule transport of calcium and magnesium. Rabbits were injected with cisplatin (2.5 mg/kg i.p. once weekly) for 3 weeks, whereas control rabbits received normal saline solution which serve...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184988
更新日期:1988-01-01 00:00:00
abstract::The three-dimensional ultrastructure of glomerular basement membrane (GBM) in surgically resected human kidneys was observed by the quick-freezing and deep-etching method. In three layers of human GBM, the middle layer exhibited polygonal meshwork structures, which were composed of fine fibrils. In addition, the outer...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188547
更新日期:1995-01-01 00:00:00
abstract::To avoid the use of aluminium as a phosphate binder, patients on CAPD who were stable were dialysed against a peritoneal dialysis fluid which was magnesium free. A mixture of calcium and magnesium carbonate was used as a phosphate binder over a period in excess of 1 year. Vitamin D analogues were used in the majority....
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187238
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND/AIMS:Genetic cell ablation using the human diphtheria toxin receptor (hDTR) is a new strategy used for analysing cellular function. Diphtheria toxin (DT) is a cytotoxic protein that leaves mouse cells relatively unaffected, but upon binding to hDTR it ultimately leads to cell death. We used a podocyte-specif...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000485664
更新日期:2018-01-01 00:00:00
abstract::The effect of changes in the dialysate calcium concentration on calcium fractions and parathyroid hormone species in plasma during hemodialysis has been examined. C-terminal immunoreactive parathyroid hormone was suppressed when plasma calcium increased by greater than 25% whereas N-terminal fragments demonstrated an ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180870
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:The development of abnormalities in red blood cell (RBC) deformability in patients undergoing hemodialysis remains a major problem, because it is related to peripheral microcirculation, oxygen supply, and various complications in such patients. gamma-Linolenic acid (GLA; 18:3n-6), one of the polyunsaturated ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045729
更新日期:2000-10-01 00:00:00
abstract::A 37-year-old female presented with acute onset of glomerulonephritis 10 days following an upper respiratory infection. Serum complement components were depressed and proteinuria exceeded 3.0 g daily. Renal biopsy revealed granular staining of IgG and C3 along the basement membrane as well as small amounts of IgA in a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183980
更新日期:1986-01-01 00:00:00
abstract::4 patients on regular dialysis were studied by the echocardiographic method during ultrafiltration and dialysis performed sequentially according to two different protocols. Blood pressure, heart rate, cardiac output, stroke volume, systolic and diastolic dimension of the left ventricle, systolic and diastolic volumes ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182448
更新日期:1982-01-01 00:00:00
abstract::Glomerular morphological changes produced by 5-hour intravenous infusion of endotoxin (40 micrograms/kg/h) were studied in 57 rabbits. During endotoxin infusion all animals developed signs of endotoxemia, anemia, and transient leukopenia and thrombocytopenia. Acute renal failure also developed in all animals. By light...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185777
更新日期:1989-01-01 00:00:00
abstract::Nephrotoxic agents such as puromycin aminonucleoside (PAN) and sodium maleate (MAL) have been used to induce experimental glomerular proteinuria and tubular disease, respectively. Current studies show that PAN caused a massive loss of albumin in the urine while not affecting the excretion of the smaller, sex-dependent...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182134
更新日期:1981-01-01 00:00:00
abstract::This study was undertaken to test the hypothesis that ischemia prior to transplantation causes tubular damage without clinical evidence of graft dysfunction. The urinary excretion of fructose-1,6-bisphosphatase (EC 3.1.3.11, FBPase), a cytosolic enzyme located exclusively in the proximal tubules, and the lysosomal enz...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000190248
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045634
更新日期:2000-05-01 00:00:00
abstract::Plasma and urine beta-2-microglobulin (B2m) were measured in 37 renal transplant recipients and 34 healthy subjects. Serum B2m was found to be a more sensitive index of renal function than serum creatinine. Renal transplant recipients had significantly higher urine B2m when compared with normal controls. Normal subjec...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183376
更新日期:1985-01-01 00:00:00
abstract::Fibrinogen fragments (X, Y, D and E) and fibrin fragments (D-dimer and E) were examined in the urine of 52 patients with various types of renal diseases. One or more of the fibrinogen fragments were detectable in all the urine specimens. D-Dimer together with fibrinogen fragments was found in 38 of the 52 patients. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182833
更新日期:1982-01-01 00:00:00
abstract::Urate deposits within microtophi were found in 8% of unselected autopsies in Brisbane, Australia. Significant association were demonstrated with (a) a history of gouty arthritis and (b) the existence of nitrogen retention and renal disease of apparently primary, but not gouty, origin. However, in 26% of the patients, ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182373
更新日期:1981-01-01 00:00:00
abstract::Most hypertensive subjects are overweight, and as a consequence have an increased prevalence of hypercholesterolaemia, impaired glucose tolerance, and left ventricular hypertrophy. Reduction of the blood pressure by antihypertensive drugs without control of the obesity leaves these additional risk factors for cardiova...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184543
更新日期:1987-01-01 00:00:00
abstract::Renal nerves were stimulated either directly (loop electrodes) or indirectly (bilateral carotid occlusion with maintenance of control blood pressure) in anesthetized dogs to determine the effects on renal blood flow (RBF), glomerular filtration rate (GFR), sodium excretion (UNaV), and intrarenal distribution of blood ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180454
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. AIM:To assess the correlation of serum sclerostin levels ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000443845
更新日期:2016-01-01 00:00:00
abstract::In 20 patients with nephrotic syndrome (10 minimal change glomerulonephritis, MCN; 10 focal glomerulosclerosis, FGS) the peripheral blood lymphocytes showed a statistically significant increase in IgG-bearing cells (SIgG-C) in comparison with 30 patients with other histological types of primary glomerulonephritis with...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183253
更新日期:1984-01-01 00:00:00
abstract::Blood eosinophils were counted by the counting-chamber method in 21 regular hemodialysis patients. Before dialysis, eosinophil counts were within the normal range in all patients (mean 98 cells/mm3, range 6-350). After the first 15 min of hemodialysis, with not reused coils or hollow-fiber dialysers, a significant dro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182805
更新日期:1982-01-01 00:00:00
abstract::Creatinine clearance has been repeatedly measured in three groups of chronic uremics. In the first control group (31 cases), following a conventional low-protein diet, creatinine clearance declined linearly with time. In the second group (12 cases), following very low nitrogen diet supplemented with essential amino ac...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182036
更新日期:1981-01-01 00:00:00
abstract::We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated followi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180453
更新日期:1975-01-01 00:00:00
abstract::Hematuria and proteinuria in rheumatoid arthritis (RA) are commonly associated with drug therapy but occur independently of drugs, amyloid or urologic disorders. The latter occurrences suggest a primary renal lesion associated with RA. Review of reported renal biopsies identifies mesangial glomerulopathy as a common f...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185262
更新日期:1989-01-01 00:00:00
abstract::Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046001
更新日期:2001-07-01 00:00:00
abstract::Renal handling of urate, xanthine and hypoxanthine was studied in a hypouricemic patient who had increased plasma concentrations of xanthine and hypoxanthine. The patient, a 50-year-old man, had been suffering from Parkinson's disease, while neither systemic disorders nor particular renal diseases known to affect plas...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186961
更新日期:1992-01-01 00:00:00
abstract::Idiopathic hypercalciuria, though a common cause of nephrolithiasis, has not been recognized to cause hypocalcemia and severe bone disease. We describe an adolescent with idiopathic hypercalciuria who presented initially with severe hypocalcemia and osteoporosis and this was later complicated by recurrent renal calcul...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186878
更新日期:1992-01-01 00:00:00
abstract::Previous studies of IgA nephropathy have demonstrated a number of prognostically significant clinical and pathological factors in groups of patients with the full histological spectrum of the disease. Whether these factors can be applied to a group of IgA nephropathy patients with disease of moderate degree is unknown...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184518
更新日期:1987-01-01 00:00:00
abstract::A patient with collagenofibrotic glomerulopathy associated with hepatic persinusoidal fibrosis is described. Renal biopsy revealed that the glomerular tufts contained homogeneous material that was proved by electron microscopy to be collagen fibers. The material was reactive to anti-type III collagen monoclonal antibo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187180
更新日期:1993-01-01 00:00:00