Pharmacologic approach to the maintenance of urate homeostasis.

abstract：:In order to elucidate the cells produced from human glomerular cultures, a pre-embedding ultrastructural immunoperoxidase technique was developed to investigate the precise localisation of a panel of monoclonal antibodies specific to human glomerular antigens in situ and used to identify the same antigens in vitro. Th...

journal_title：Nephron

authors： Jackson AE,Atkins RC,Glasgow EF

更新日期：1989-01-01 00:00:00

abstract：:A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...

journal_title：Nephron

authors： Lin CH,Huang JJ,Liu HL,Lee SY,Hsieh RY,Tseng CC

更新日期：2002-09-01 00:00:00

abstract：:Platelet-activating factor (PAF) belongs to a new class of lipid chemical inflammatory mediators described as acetyl glyceryl ether phosphorylcholine. Although PAF has been implicated in kidney injury, its role in renal immune injury has not been clearly defined yet. We studied the levels of PAF in the plasma and urin...

journal_title：Nephron

authors： Iatrou C,Moustakas G,Antonopoulou S,Demopoulos CA,Ziroyiannis P

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:Diastolic dysfunction (DD) and low levels of thyroid hormones (TH) are frequent found in chronic kidney disease; both are associated with all-cause and cardiovascular mortality. However, a link between them has not yet been established. The aim of this study was to analyze DD as a surrogate marker of fi...

journal_title：Nephron

authors： Sánchez V,Paniagua R,Prado MD,Mora C,Orihuela O,Martínez-Baca F,Pérez EE,Calzada C,Romero R,Avila M

更新日期：2017-01-01 00:00:00

abstract：:Serum ferritin level has been shown by many investigators to be a good indicator of bone marrow iron stores in normal subjects. Although this correlation may hold in some pathological situations, it is lost in others. In leukemia a dissociation has been observed between serum ferritin levels and bone marrow iron store...

journal_title：Nephron

authors： Nuwayri-Salti N,Jabre F,Saab G,Daouk M,Salem Z

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:Increased susceptibility of the kidney to acute renal failure (ARF) in the setting of sepsis even in the absence of systemic hypotension is well known. In the hypothesis that the proinflammatory cytokines and lipopolysaccharide (LPS) in gram-negative sepsis can directly cause renal tubular cell apoptosi...

journal_title：Nephron

authors： Jo SK,Cha DR,Cho WY,Kim HK,Chang KH,Yun SY,Won NH

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND/AIM:The impact of dialysis membrane permeability on neutrophil transmigration properties in vitro was examined in the present study. This issue has not been fully scrutinized before. METHODS:We studied the capacity of neutrophils collected from a group of dialysis patients randomly treated with cuprophan, l...

journal_title：Nephron

authors： Moshfegh A,Jacobson SH,Halldén G,Thylén P,Lundahl J

更新日期：2002-08-01 00:00:00

abstract：:Pulmonary calcifications are known to occur in patients with chronic renal failure. Recently, scintigrams with bone-seeking radionuclides have been used to detect subclinical pulmonary calcium deposits. We studied 18 children on maintenance dialysis without evidence of pulmonary calcification on chest X-ray. Four chil...

journal_title：Nephron

authors： Drachman R,Baillet G,Gagnadoux MF,de Vernejoul P,Broyer M

更新日期：1986-01-01 00:00:00

abstract：:To clarify the in vivo involvement of cellular adhesion molecules and cytokines in human glomerulonephritis, we have investigated the glomerular and interstitial expression of intercellular adhesion molecule 1 (ICAM-1) in 69 kidney biopsy specimens by immunohistochemical methods and its correlation with serum bioactiv...

journal_title：Nephron

authors： Yokoyama H,Takaeda M,Wada T,Ohta S,Hisada Y,Segawa C,Furuichi K,Kobayashi K

更新日期：1997-01-01 00:00:00

abstract：:The clinicopathological findings of isolated mesangial C3d deposition in the absence of other complement components or immunoglobulins are summarized. 55 out of 242 individual human renal biopsies examined by immunoperoxidase microscopy had isolated C3d deposition. This group consisted of 12 patients with chronic glom...

journal_title：Nephron

authors： Doi T,Kanatsu K,Suehiro F,Nagai H,Yoshida H,Hamashima Y

更新日期：1987-01-01 00:00:00

abstract：:Cadmium-induced renal effects were followed (1989) in 16 workers previously exposed to cadmium, who had been shown 5 years earlier to have had tubular damage; all but 1 worker had persistent tubular damage (beta 2-microglobulin > 60 micrograms/mmol creatinine). The mean glomerular filtration rate (GFR) decreased from ...

journal_title：Nephron

authors： Järup L,Persson B,Edling C,Elinder CG

更新日期：1993-01-01 00:00:00

abstract：:Thrombospondin (TSP) is a multifunctional glycoprotein that is synthesized by a variety of cells including mesangial cells (MCs). To clarify the effect of TSP on the pathogenesis of diabetic nephropathy, we studied the effect of glucose concentrations on TSP synthesis in cultured human MCs. Thereafter, the effects of ...

journal_title：Nephron

authors： Tada H,Isogai S

更新日期：1998-01-01 00:00:00

abstract：:The pharmacokinetics of procainamide in patients on continuous ambulatory peritoneal dialysis have been studied. A mean peak plasma concentration of 3.2 +/- 0.6 microgram/ml was achieved about 2 h after a single 500-mg oral procainamide hydrochloride dose. The procainamide elimination half-life ranged from 6.1 to 15.3...

journal_title：Nephron

authors： Raehl CL,Moorthy AV,Beirne GJ

更新日期：1986-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a worldwide public health problem associated with a high prevalence of cardiovascular disease (CVD) and impaired quality of life. Previous research for preventing loss of glomerular filtration rate (GFR) has focused on reducing blood pressure (BP) and proteinuria. Angiotensin converting...

journal_title：Nephron

authors： Ahmed A,Jorna T,Bhandari S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a cytokine which plays an important role in the division, proliferation and migration of endothelial cells. In the kidney, VEGF expression is found in glomerular podocytes and in tubular epithelial cells, which may result in acute inflammatory reactions. METHODS:...

journal_title：Nephron

authors： Prakash S,Agrawal S,Kumar S,Prasad N

更新日期：2015-01-01 00:00:00

abstract：:While the bulk of renal hypertrophy induced by contralateral nephrectomy or a high-protein diet consists of tubular cell growth, there is some evidence suggesting that mesangial cells play a role in this phenomenon. Previous data suggest that this role of mesangial cells is associated with their proliferation. We, the...

journal_title：Nephron

authors： Weissgarten J,Modai D,Berman S,Cohn M,Galperin E,Averbukh Z

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND/AIMS:Genetic cell ablation using the human diphtheria toxin receptor (hDTR) is a new strategy used for analysing cellular function. Diphtheria toxin (DT) is a cytotoxic protein that leaves mouse cells relatively unaffected, but upon binding to hDTR it ultimately leads to cell death. We used a podocyte-specif...

journal_title：Nephron

authors： Stevens M,Neal CR,Salmon AHJ,Bates DO,Harper SJ,Oltean S

更新日期：2018-01-01 00:00:00

abstract：:Copper (Cu) and zinc (Zn) were measured in urine, serum and tissues from rats with nephrotic syndrome (NS) induced with a single subcutaneous dose of puromycin aminonucleoside (PAN; 15 mg/100 g BW). Control animals were pair-fed. Urine was collected daily, and the rats were sacrificed on day 10. PAN-nephrotic rats had...

journal_title：Nephron

authors： Pedraza-Chaverrí J,Torres-Rodríguez GA,Cruz C,Mainero A,Tapia E,Ibarra-Rubio ME,Silencio JL

更新日期：1994-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean +/...

journal_title：Nephron

authors： Goldman M,Vandenabeele P,Moulart J,Amraoui Z,Abramowicz D,Nortier J,Vanherweghem JL,Fiers W

更新日期：1990-01-01 00:00:00

abstract：:The effect of imidazole-2-hydroxibenzoate on urinary excretion rates of glycosaminoglycans and albumin in 22 insulin-dependent diabetics with albumin excretion rates under 300 mg/day was evaluated in a 165-day double blind crossover study. Unlike placebo, the drug reduced glycosaminoglycan and albumin excretion rates ...

journal_title：Nephron

authors： Baggio B,Briani G,Cicerello E,Gambaro G,Giorato C,Iori E,Lavagnini T,Crepaldi G

更新日期：1988-01-01 00:00:00

abstract：:A case of inferior vena caval compression by hepatic cysts as a complication of adult polycystic kidney disease is presented and its management is discussed. ...

journal_title：Nephron

authors： Yaqoob M,Saffman C,Finn R,Carty AT

更新日期：1990-01-01 00:00:00

abstract：:Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending ...

journal_title：Nephron

authors： Di Paolo N,Guarnieri A,Loi F,Sacchi G,Mangiarotti AM,Di Paolo M

更新日期：1993-01-01 00:00:00

abstract：:29 patients receiving haemodialysis treatment for chronic renal failure were divided into two groups on the basis of the presence or absence of bone disease as defined by radiology and bone alkaline phosphatase. The group of patient with bone disease showed a significantly greater increase in protein-bound calcium dur...

journal_title：Nephron

authors： Gosling P,Naik RB,Price CP,Sammons HG,Robinson BH

更新日期：1979-01-01 00:00:00

abstract：:Blood eosinophils were counted by the counting-chamber method in 21 regular hemodialysis patients. Before dialysis, eosinophil counts were within the normal range in all patients (mean 98 cells/mm3, range 6-350). After the first 15 min of hemodialysis, with not reused coils or hollow-fiber dialysers, a significant dro...

journal_title：Nephron

authors： Bodner G,Peer G,Zakuth V,Spirer ZH,Aviram A

更新日期：1982-01-01 00:00:00

abstract：:Following successful kidney transplantation, renal anemia is gradually corrected during the first 3-4 months. Serum erythropoietin (EPO) levels are increased after the first postoperative day following grafting. In this study, the serum EPO levels in the early posttransplant phase were investigated in 8 living-donor a...

journal_title：Nephron

authors： Goch J,Birgegård G,Wikström B,Tufveson G,Danielson BG

更新日期：1992-01-01 00:00:00

abstract：:The cytoprotective effect of ulinastatin was studied in LLC-PK1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release of lactate dehydrogenase and a decrease in the amount of remaining protein. In the cell injury models treated with ...

journal_title：Nephron

authors： Ishibashi M,Yamasaki F,Nakakuki M,Shinkawa T,Mizota M

更新日期：1997-01-01 00:00:00

abstract：:Fifteen patients with advanced renal failure (creatinine clearance less than 25 ml/mn) and with severe albuminuria (greater than 1.5 g/24 h) were put on a low-protein (0.3 g/kg body weight), low-phosphorus (5-7 mg/kg body weight) diet supplemented with essential amino acids and ketoanalogues. During the 6-month follow...

journal_title：Nephron

authors： Aparicio M,Bouchet JL,Gin H,Potaux L,Morel D,de Precigout V,Lifermann F,Gonzalez R

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The development of abnormalities in red blood cell (RBC) deformability in patients undergoing hemodialysis remains a major problem, because it is related to peripheral microcirculation, oxygen supply, and various complications in such patients. gamma-Linolenic acid (GLA; 18:3n-6), one of the polyunsaturated ...

journal_title：Nephron

authors： Iijima S,Otsuka F,Kikuchi H,Yamada K,Nakajima T,Yahiro K,Kondo A

更新日期：2000-10-01 00:00:00

abstract：:3-Deoxyglucosone (3-DG) has been identified as an intermediate of the Maillard reaction in vitro. We measured serum 3-DG levels using gas chromatography/mass spectrometry and found a marked elevation in serum 3-DG levels in uremic patients compared with healthy subjects. The uremic patients with diabetes showed signif...

journal_title：Nephron

authors： Niwa T,Takeda N,Miyazaki T,Yoshizumi H,Tatematsu A,Maeda K,Ohara M,Tomiyama S,Niimura K

更新日期：1995-01-01 00:00:00

abstract：:From a review of the literature regarding kinetic models used for assessing the adequacy of hemodialysis, no definite conclusions can be drawn as to whether the classical urea kinetic model (UKM) or modified direct dialysis quantification (mDDQ) is more reliable. We compared mDDQ with classical UKM and with a modified...

journal_title：Nephron

authors： Bosticardo GM,Alloatti S

更新日期：1996-01-01 00:00:00