Abstract:
:The renal cortex of anesthetized dogs was found to contain per gram lyophilized dry weight 9.5+/-0.6 micronmol ATP, 3.2+/-0.5 MICRONMOL ADP, 0.68+/-0.3 MICRONMOL AMP, and 22.5+/-4.4 micronmol Pi. These amounts were unchanged by the administration of moderate amounts of saline or hypertonic mannitol in load doses of about 20mmol/kg. Fructose in doses of 5 mmol/kg was found to cause a marked decrease in cortical ATP content. In doses of 20 mmol/kg fructose not only caused a decrease in ATP, but in total adenine nucleotides and Pi content as well. These results are consistent with the mode of action proposed for fructose, in rat kidney.
journal_name
Nephronjournal_title
Nephronauthors
Urbaitis BK,Blake WDdoi
10.1159/000180833subject
Has Abstractpub_date
1977-01-01 00:00:00pages
226-31issue
4eissn
1660-8151issn
2235-3186journal_volume
18pub_type
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