Effect of fructose and mannitol on dog renal cortical adenine nucleotide content, in vivo.

Abstract:

:The renal cortex of anesthetized dogs was found to contain per gram lyophilized dry weight 9.5+/-0.6 micronmol ATP, 3.2+/-0.5 MICRONMOL ADP, 0.68+/-0.3 MICRONMOL AMP, and 22.5+/-4.4 micronmol Pi. These amounts were unchanged by the administration of moderate amounts of saline or hypertonic mannitol in load doses of about 20mmol/kg. Fructose in doses of 5 mmol/kg was found to cause a marked decrease in cortical ATP content. In doses of 20 mmol/kg fructose not only caused a decrease in ATP, but in total adenine nucleotides and Pi content as well. These results are consistent with the mode of action proposed for fructose, in rat kidney.

journal_name

Nephron

journal_title

Nephron

authors

Urbaitis BK,Blake WD

doi

10.1159/000180833

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

226-31

issue

4

eissn

1660-8151

issn

2235-3186

journal_volume

18

pub_type

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