Naloxone-induced dissociation of oxytocin and prolactin releases.

Abstract:

:Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT release was observed. These results demonstrate that concomitant releases of OT and PRL in response to a given physiologic stimulus (stress) can be dissociated and suggest that the hypothalamic events which are responsible for the release of these hormones during stress are different.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Samson WK,McDonald JK,Lumpkin MD

doi

10.1159/000124053

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

68-71

issue

1

eissn

0028-3835

issn

1423-0194

journal_volume

40

pub_type

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