Abstract:
:In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In addition, estradiol also increased the pituitary expression of sst5. On the other hand, testosterone had no effects on the expression of these receptor subtypes. Mature female goldfish were found to have higher sst1 and sst5 expression in the pituitary, as well as a higher expression of sst1 in the forebrain compared to sexually regressed animals. As estradiol treatment increases serum growth hormone levels in goldfish, these data suggest that sst1 and sst5 receptors are likely not directly involved in this aspect of growth hormone release.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Canosa LF,Lin X,Peter REdoi
10.1159/000071963subject
Has Abstractpub_date
2003-08-01 00:00:00pages
81-9issue
2eissn
0028-3835issn
1423-0194pii
71963journal_volume
78pub_type
杂志文章abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127121
更新日期:1996-09-01 00:00:00
abstract::The effect of in vivo corticosterone manipulation on binding sites for the excitatory neurotransmitter glutamate was determined using radioligand binding to rat brain cryostat sections and crude synaptic membranes. 3H-glutamate binding to regions of the dorsal hippocampal formation was significantly decreased in adren...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125017
更新日期:1988-09-01 00:00:00
abstract::Neurons synthesizing growth hormone releasing factor were detected by immunocytochemistry with specific antiserum against synthetic rat hypothalamic growth hormone releasing factor. Growth hormone releasing factor immunoreactive neurons which also showed tyrosine hydroxylase immunoreactivity were located in the ventro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124172
更新日期:1985-08-01 00:00:00
abstract::Serotonin, a biologically active amine, is related to carcinoid syndrome in functioning neuroendocrine tumors (NETs). Telotristat ethyl is a novel inhibitor of the tryptophan hydroxylase (TPH), a key enzyme in the production of serotonin. While its use in patients with carcinoid syndrome and uncontrolled diarrhea unde...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000502200
更新日期:2020-01-01 00:00:00
abstract::Immunoneutralization of endogenous gonadal steroids has recently been shown to modify pineal beta-adrenoceptor function in intact Merino ewes. In the current study, interactions between gonadal steroids and these receptors have been further investigated. beta-Adrenoceptor density and binding affinity both showed time-...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124225
更新日期:1985-12-01 00:00:00
abstract::The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123389
更新日期:1982-10-01 00:00:00
abstract::Vasopressin-containing neurosecretory cells are partly regulated by GABAergic neurons present both at the hypothalamic and the pituitary level. In the present work, we compared GABA effects on vasopressin release from posterior pituitaries of Sprague-Dawley (SPD), Wistar (W), Wistar-Kyoto (WKY) and spontaneously hyper...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126585
更新日期:1993-11-01 00:00:00
abstract::In previous studies we demonstrated that insulin-like growth factor I (IGF-I) induces pituitary vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I-induced prolactin (PRL) release is mediated by VIP. In this study, we investigate the mitotropic action of IGF-I and VIP on pituitary lactotr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000070900
更新日期:2003-05-01 00:00:00
abstract::The effect of estrogen on prolactin (PRL) synthesis at a single-cell level was studied by in situ hybridization and immunohistochemistry. Long-term estrogen treatment increased PRL-containing cells from 10-20% of total cell population to 80-90%, as revealed by immunohistochemistry. PRL mRNA containing cells also incre...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124493
更新日期:1986-01-01 00:00:00
abstract::Overt Cushing's syndrome is a rare disorder with an annual incidence of 2-3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing's syndrome in certain risk populations such as patients with type 2 diabetes or ...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000314297
更新日期:2010-01-01 00:00:00
abstract::Introduction The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol on arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509583
更新日期:2020-06-22 00:00:00
abstract:INTRODUCTION:Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs). OBJECTIVE:This study aimed to assess whether VFs may be associated with sagittal spine deformities, arthropathy, impaired quality of life (QoL), pain and disability. METHODS:Thirty-eight ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000511811
更新日期:2020-09-25 00:00:00
abstract::The present study was designed to investigate the role of glucocorticoids in mediating the stimulatory effect of interleukin-1 (IL-1) upon the adrenocortical (AC) axis. Intact male rats were injected with either vehicle or dexamethasone (DEX) (5-50 micrograms/100 g b.w.) and were subsequently exposed to ether stress o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125294
更新日期:1989-12-01 00:00:00
abstract::Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and tryptophan (T) concentrations varied only slightly. Serotonin (5-HT) concentrations showed characteristic changing patterns in many hypothalamic, limbic and midbrain ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122536
更新日期:1976-01-01 00:00:00
abstract::The inhibitory effects of pituitary allografts on the prolactin (PRL)-secretory system are presumed to be consequences of the unabated release of PRL by the allografts. In the present studies we used pituitary allografts in the Golden Syrian hamster to address the following questions: (a) Do allografts of adult adenoh...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127068
更新日期:1996-05-01 00:00:00
abstract::In previous studies, we have shown that male Wistar rats exposed to a single inescapable stressor session (15 min restraint) exhibited 24 h later an anxiogenic-like behavior in the elevated plus-maze (EPM), which was reversed by inhibition of corticosterone (CS) synthesis with metyrapone (75 mg/kg i.p.) 3 h before str...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054643
更新日期:2001-04-01 00:00:00
abstract::Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000089749
更新日期:2005-01-01 00:00:00
abstract::In the Djungarian hamster Phodopus sungorus, the daily temporal pattern of synthesis and release of pineal hormone melatonin, mainly the length of the period of elevated melatonin levels, may be involved in transferring the information on day length to the neuroendocrine-gonadal axis. The present study investigated th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123895
更新日期:1984-03-01 00:00:00
abstract::Recent evidence suggests that the free amino-terminal fragment of procalcitonin (N-PCT) plays a role in the central control of feeding behavior and energy homeostasis. However, little is known about the mechanisms through which N-PCT works. Here we report that intracerebroventricular administration of N-PCT to free-fe...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000155137
更新日期:2008-01-01 00:00:00
abstract::Secretion of the growth hormone (GH) in spontaneously hypertensive (SH) male rats has been determined and compared with that of normotensive Wistar-Kyoto (WKY) controls. In a first set of experiments, plasma GH concentration and pituitary GH content were measured in SH rats 30, 60 and 90 days old. 30-day rats showed r...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125617
更新日期:1990-10-01 00:00:00
abstract::We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125920
更新日期:1991-10-01 00:00:00
abstract::Growth hormone-releasing hormone (GHRH) stimulates GH secretion in man and the hormonal response is specific. The attenuation of GH response to bolus GHRH after prior exposure of GHRH of up to 24 h was not demonstrated in normal or GH-deficient subjects after more prolonged exposure. This suggests that the partial los...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000125793
更新日期:1991-01-01 00:00:00
abstract::Neonatal rats exhibit a period of diminished pituitary and adrenocortical responses to stress during the first 2 weeks of life. Since thyroid hormones are known to affect brain development, modulation of these responses to stress by alterations in thyroid hormone status have been investigated in hypothyroid (Hypo) and...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125232
更新日期:1989-09-01 00:00:00
abstract::The injection of purified alpha-bungarotoxin (alpha-BTX), an antagonist of the muscle nicotinic cholinergic receptors, into the third ventricle (3rd V) of ovariectomized rats decreased the frequency of pulses of luteinizing hormone (LH) but had no significant effect on the amplitude or nadir of LH secretion. Approxima...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125153
更新日期:1989-05-01 00:00:00
abstract::The capability of the anterior pituitary gland to secrete growth hormone (GH) in response to an intravenous injection of growth hormone-releasing factor, hpGRF-44, was evaluated in male rats ranging from 22 days to 24 months of age. The increase in GH concentrations following a submaximal dose of hpGRF-44 (0.5 microgr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123594
更新日期:1983-12-01 00:00:00
abstract::Patients with active acromegaly are frequently insulin resistant, glucose intolerant, and at risk for developing overt type 2 diabetes. At the same time, these patients have a relatively lean phenotype associated with mobilization and oxidation of free fatty acids. These features are reversed by curative surgical remo...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000430819
更新日期:2016-01-01 00:00:00
abstract::Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123554
更新日期:1983-10-01 00:00:00
abstract::Castration of male and female rats resulted in a marked rise in serum LH. The rise in serum LH was partially or completely prevented by injection of prolactin (Prl), by implantation of a small amount of Prl in the median eminence (ME), by grafting 2 anterior pituitaries (APs) underneath the kidney capsule, or by trans...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122679
更新日期:1977-01-01 00:00:00
abstract::Activin A immunoreactivity has been localized within the nucleus tractus solitarius and its projections into regions of the hypothalamus such as the paraventricular nucleus. However, the function of activin within the central nervous system is unclear. Because these regions of the brain are involved in the regulation ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126399
更新日期:1993-03-01 00:00:00
abstract::Endocrine pancreatic tumours (EPTs) are uncommon, with a major challenge to alert physicians to their recognition and requirements of treatment. Functioning EPTs cause well-known clinical syndromes of hormone excess. Insulinomas, gastrinomas and glucagonomas are most common; vipomas and somatostatinomas are rare. EPTs...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000080744
更新日期:2004-01-01 00:00:00