Abstract:
INTRODUCTION:Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs). OBJECTIVE:This study aimed to assess whether VFs may be associated with sagittal spine deformities, arthropathy, impaired quality of life (QoL), pain and disability. METHODS:Thirty-eight patients with acromegaly (median age 55 years, 20 males) and 38 matched-control subjects were evaluated by a low dose sagittal and coronal planes, X-ray imaging system (EOS®-2D/3D) for morphometric VFs, radiological signs of spine arthropathy and spine deformities (Cobb thoracic index ≥ 40°, pelvic incidence minus lumbar lordosis ≥ 10°, pelvic tilt > 20°, sagittal vertical axis ≥ 4 cm) determining sagittal spine imbalance. Acromegalic patients were also evaluated by questionnaires for QoL (Acromegaly QoL Questionnaire [AcroQoL] and Short Form-36 [SF36]), pain and disability (Western Ontario and Mc Master University [WOMAC]. RESULTS:Acromegalic patients showed higher prevalence of thoracic hyperkyphosis (i.e., Cobb thoracic index ≥ 40°; p=0.04), pelvic tilt > 20° (p=0.02) than control subjects. VFs were found in 34.2% of acromegalic patients (p=0.003 vs. control subjects), in relationship with higher prevalence of hyperkyphosis (p=0.03), pelvic tilt > 20° (p=0.04), sagittal vertical axis ≥ 4 cm (p=0.03) and moderate/severe subchondral degeneration (p=0.01). Moreover, patients with VFs had lower AcroQoL general health (p=0.007) and SF36 general health (p=0.002) scores and higher WOMAC pain (p=0.003) and global (p=0.009) scores than patients who did not fracture. CONCLUSIONS:In acromegaly, VFs may be associated with spine deformities and sagittal imbalance, spine arthropathy, impaired QoL and disability.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Cellini M,Biamonte E,Mazza M,Trenti N,Ragucci P,Milani D,Ferrante E,Rossini Z,Lavezzi E,Sala E,Mantovani G,Arosio M,Fornari M,Balzarini L,Lania AG,Mazziotti Gdoi
10.1159/000511811subject
Has Abstractpub_date
2020-09-25 00:00:00eissn
0028-3835issn
1423-0194pii
000511811pub_type
杂志文章abstract::The aim of this study was to verify whether prolonged exposure of cultured rat anterior pituitary cells to high glucose can alter growth hormone (GH) release and responsiveness to secretagogues. Therefore, we cultured anterior pituitary cells obtained from normal male Sprague-Dawley rats in presence of normal (6 mM) o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125947
更新日期:1991-11-01 00:00:00
abstract::Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126225
更新日期:1992-08-01 00:00:00
abstract::Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus. Few studies have reported the effects of CORT on hippocampal long-term potentiation (LTP). In the CA1 region of the hippocampal slice, we studied the relative increase in population spike (PS) amplitude after inducing tetanus (...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126717
更新日期:1994-07-01 00:00:00
abstract::To study the eyes' role in maintaining the circadian rhythm in pituitary-adrenal function, 24-h patterns of corticosterone levels were compared in intact and blinded adult female rats. Rats were blinded by optic enucleation at approximately 80 days of age. Nonstress plasma corticosterone levels were determined fluorom...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122495
更新日期:1976-01-01 00:00:00
abstract::Cell-intact patch-clamp recording was used to determine the electrophysiological responses of sheep anterior pituitary gonadotropes to stimulation with gonadotropin-releasing hormone (GnRH). Cells were identified prior to recording by reverse haemolytic plaque assay (RHPA), or using morphological criteria in preparati...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126605
更新日期:1993-12-01 00:00:00
abstract::The sheep exhibits a marked sex difference in the timing of the pubertal increase in luteinizing hormone (LH). Male lambs undergo a reduction in sensitivity to inhibitory steroid feedback, leading to an increase in LH by 10 weeks of age, but females remain hypersensitive until 30 weeks of age. Endogenous opioids suppr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126312
更新日期:1992-12-01 00:00:00
abstract::The in vitro release of LHRH from hypothalami of adult male rats (intact, 5-day castrates, 5-day castrates replaced with various doses of testosterone) was measured under basal conditions and after the addition of KCl, the opiate antagonist naloxone or the opiate agonist DAGO to the perifusion medium. Hypothalami from...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124662
更新日期:1986-01-01 00:00:00
abstract::The effects of adrenalectomy (ADX) and dexamethasone (DEX) treatment on brain dopamine (DA) receptors of ovariectomized (OVX) rats were investigated by autoradiography using binding of the D1 and D2 antagonists ligands [3H]SCH 23390 and [3H]spiperone, respectively. Fourteen days after ADX, D1 receptors decreased in th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126158
更新日期:1992-04-01 00:00:00
abstract::In vivo single-unit extracellular recording was used to assess neuronal membrane sensitivity at the level of the midbrain central gray (MCG) to the iontophoresis of luteinizing hormone releasing hormone (LHRH) and beta-endorphin (beta-END). The percentage of change in firing rate was evaluated to determine the effect ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124792
更新日期:1987-06-01 00:00:00
abstract::Studies were undertaken to characterize the secretion of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) into the hypophysial-portal circulation of the conscious sheep. In addition, we examined the temporal relationship between the secretion of these two hypothalamic peptides and the secretion of t...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125141
更新日期:1989-04-01 00:00:00
abstract::Chronic exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) increases corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) gene expression in the rat hypothalamus. The levels of circulating gonadal steroids concurrently modulate both neuropeptides in male and female rats. However, it remains unkno...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054685
更新日期:2001-09-01 00:00:00
abstract::Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000064428
更新日期:2002-08-01 00:00:00
abstract::Because of some indication that FSH secretion is less dependent than LH secretion on GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist (antag) on LH and FSH secretion. We first showed that pituitary cells superfused with GnRH showed a similar pattern of suppressed secretion of both LH ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124081
更新日期:1985-03-01 00:00:00
abstract::During adult-onset peripheral hypothyroidism, the brain maintains normal levels of thyroid hormone for some time through a mechanism of 'central homeostasis'. Although onset, duration, and termination of such a homeostatic phenomenon have been recently evaluated in rat models, the mechanism behind remains unknown. Dur...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000107580
更新日期:2007-01-01 00:00:00
abstract::A number of neurochemical messengers have been shown to act directly on the melanotrope cells of the pars intermedia of Xenopus laevis to regulate alpha MSH secretion. In the present study the possibility that the melanotropes are also indirectly controlled has been examined. For this purpose, the characteristics of a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125853
更新日期:1991-07-01 00:00:00
abstract::Primary cultures from fetal rat brain contain angiotensin II immunoreactivity in neurons. To study the origin of this immunoreactivity, primary cultures were incubated with [3H]-valine or [3H]-isoleucine. A time-dependent incorporation of radioactivity into immunoprecipitable angiotensin II was observed. Incubation of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123438
更新日期:1983-01-01 00:00:00
abstract::In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125777
更新日期:1991-06-01 00:00:00
abstract::Previous studies have shown that neonatal administration of monosodium glutamate (MSG) results in a clearly defined lesion of the arcuate nucleus which disrupts mechanisms regulating normal FSH but not LH secretion in the adult female hamster. The present study was designed to investigate the effects of neonatally adm...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123296
更新日期:1982-03-01 00:00:00
abstract::Previous work has demonstrated that physiological concentrations of 17beta-estradiol can protect the female rat brain against middle cerebral artery occlusion (MCAO)-induced ischemic damage. The present study examined whether therapeutic doses of the clinically relevant selective estrogen receptor modulator (SERM), ta...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000068332
更新日期:2003-01-01 00:00:00
abstract::Interruption of hypothalamic growth hormone-releasing hormone (GHRH) secretion by administration of antiserum against GHRH (GHRH-ab) decreases growth hormone (GH) secretion and inhibits growth in rats. The present study was undertaken to investigate whether there is a period of accelerated or catch-up growth following...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126268
更新日期:1992-10-01 00:00:00
abstract::Measurements of electrical activity and intracellular Ca(2+) levels were performed in perforated-patch clamped GH(3) cells to determine the contribution of large-conductance calcium-activated K(+) (BK) channels to action potential repolarization and size of the associated Ca(2+) oscillations. By examining the dependen...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000069509
更新日期:2003-03-01 00:00:00
abstract::Normal and castrated male rats implanted with permanent right atrial cannulae were used, and sequential blood samples were taken every 2 min through the cannula. When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically eleva...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122826
更新日期:1978-01-01 00:00:00
abstract::Neonatal rats exhibit a period of diminished pituitary and adrenocortical responses to stress during the first 2 weeks of life. Since thyroid hormones are known to affect brain development, modulation of these responses to stress by alterations in thyroid hormone status have been investigated in hypothyroid (Hypo) and...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125232
更新日期:1989-09-01 00:00:00
abstract::Accumulating evidence in rodents suggests that a prolactin locally synthesized and released within the brain can act together with that taken up from the circulation to modulate neuroendocrine responses. The present study was designed to identify the regional patterns of prolactin expression in the adult and developin...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000114643
更新日期:2008-01-01 00:00:00
abstract::The feedback effect of systemically administered dexamethasone on basal plasma corticosterone levels and on adrenocortical responses to ether plus skin incision stress were studied in intact rats and in animals with bilateral dorsal or ventral hippocampectomy or fimbria section. It was found that in rats with ventral ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122974
更新日期:1980-01-01 00:00:00
abstract::In vitro and in vivo perfusion techniques were used to examine the changes in the release of beta-endorphin, methionine-enkephalin (met-enkephalin), dynorphin and luteinizing hormone releasing hormone (LHRH) in response to the corticotropin releasing factor (CRF) receptor antagonist, alpha-helical CRF9-41. All four pe...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124967
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND/AIM:Somatostatin (SST) analogs are mainstay for controlling tumor proliferation and hormone secretion in carcinoid patients. Recent data suggest that extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation may potentiate the anti-tumor effects of SST analogs in carcinoids. Additionally, ERK1/2 pho...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000341810
更新日期:2013-01-01 00:00:00
abstract::Lactotrophs, gonadotrophs, thyrotrophs and somatotrophs of the rat anterior pituitary (AP) express 68-kDa neurofilaments (NF68) and other neuronal markers. NF68 expression in the AP appears to be estrogen-dependent, but its significance is unknown. The aims of this work were: (1) to establish the expression pattern of...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000095548
更新日期:2006-01-01 00:00:00
abstract::Ghrelin is a 28-amino-acid gastric peptide that potently stimulates growth hormone (GH) secretion in vivo and in vitro. Ghrelin-expressing cells have been found in the oxyntic region of the stomach and in the arcuate nucleus of the hypothalamus. The aim of this work was to investigate the regional distribution and dev...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000068653
更新日期:2003-02-01 00:00:00
abstract::The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125536
更新日期:1990-07-01 00:00:00