Angiotensin II receptor development in the bed nucleus of the stria terminalis and other perihypothalamic brain regions of the female and male rat.

Abstract:

:Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII receptor binding sites and responsiveness within the POAH to microinjections of AII in the adult female rat, corresponding to the ventral portion of the bed nucleus of the stria terminalis (BSTV). To further characterize the age- and sex-dependent AII receptor binding in the BSTV and other brain regions, in vitro receptor autoradiography using 125I-sarcosine1, isoleucine8 AII (125I-SI AII) was performed on 2-, 4- and 10-week-old female and male rat brains. Rats of both sexes displayed an age-dependent increase in 125I-SI AII binding in the BSTV, as well as in the suprachiasmatic nucleus (SCh). There was no detectable difference in binding within the BSTV between the female and male of any age group. Prepubertal ovariectomy did not impair the expression of 125I-SI AII binding in the BSTV or the SCh of adult female rats. The developmental expression of AII receptors in the BSTV and SCh may therefore play a role in sexual maturation and regulation of sexual function in the rat.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Grove KL,Cook VI,Speth RC

doi

10.1159/000126225

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

169-77

issue

2

eissn

0028-3835

issn

1423-0194

journal_volume

56

pub_type

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