Abstract:
:In vivo single-unit extracellular recording was used to assess neuronal membrane sensitivity at the level of the midbrain central gray (MCG) to the iontophoresis of luteinizing hormone releasing hormone (LHRH) and beta-endorphin (beta-END). The percentage of change in firing rate was evaluated to determine the effect of exogenously administered estradiol benzoate (EB) and EB plus progesterone (EB + P) on the membrane sensitivity of these MCG neurons to LHRH and beta-END. Ovariectomized adult female rats were primed with EB or EB + P, or nonprimed, 24-48 h prior to recording. EB priming significantly altered the membrane sensitivity of neurons in the MCG to LHRH by increasing the number of cells excited compared to the EB + P group and the nonprimed controls (p less than 0.005). The addition of P appeared to negate this effect. Hormonal priming did not alter the response profile for beta-END iontophoresis. The results suggest an estrogen-dependent sensitivity to LHRH at the MCG which translates into an increased electrical output, ultimately facilitating lordosis behavior. P treatment dampens this excitation. beta-END's effect on neuronal membrane excitability at the MCG was not distinctly characterized under the hormonal conditions our study evaluated and may reflect a regulatory role under physiological extremes.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Schiess MC,Dudley CA,Moss RLdoi
10.1159/000124792subject
Has Abstractpub_date
1987-06-01 00:00:00pages
24-31issue
1eissn
0028-3835issn
1423-0194journal_volume
46pub_type
杂志文章abstract::Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of these effects occur in an indirect transsynaptic manner through the st...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000064428
更新日期:2002-08-01 00:00:00
abstract::The presence of vasopressin (VP) in pars distalis of rats and pigs was investigated. Using radioimmunoassay and bioassay of VP, a substance with immunological and biological properties of this hormone was found. This substance was not detected in the adenohypophysis of rats with diabetes insipidus. A partial purificat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122841
更新日期:1979-01-01 00:00:00
abstract::Molecules of astrocyte origin influence gonadotropin-releasing hormone (GnRH) release and GnRH neuronal growth and differentiation. Furthermore, type 1 astrocytes express steroid receptors, presenting the possibility that steroid actions on GnRH neurons might occur via astrocytes. Utilizing GT1-7 cells, a GnRH-secreti...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000059434
更新日期:2002-06-01 00:00:00
abstract::Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,0...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125071
更新日期:1988-12-01 00:00:00
abstract::Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124668
更新日期:1986-01-01 00:00:00
abstract::These studies investigated the effect of aging on thyroid hormone regulation of beta-endorphin in rat corpus striatum and hypothalamus. In both brain areas, basal levels of beta-endorphin declined with age. In addition, age modified the response of beta-endorphin to thyroid hormone status. Hypothyroid rats aged 6 mont...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123141
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to ki...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000227806
更新日期:2009-01-01 00:00:00
abstract::The injection of purified alpha-bungarotoxin (alpha-BTX), an antagonist of the muscle nicotinic cholinergic receptors, into the third ventricle (3rd V) of ovariectomized rats decreased the frequency of pulses of luteinizing hormone (LH) but had no significant effect on the amplitude or nadir of LH secretion. Approxima...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125153
更新日期:1989-05-01 00:00:00
abstract::Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126159
更新日期:1992-04-01 00:00:00
abstract::Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000321395
更新日期:2010-01-01 00:00:00
abstract::Interruption of hypothalamic growth hormone-releasing hormone (GHRH) secretion by administration of antiserum against GHRH (GHRH-ab) decreases growth hormone (GH) secretion and inhibits growth in rats. The present study was undertaken to investigate whether there is a period of accelerated or catch-up growth following...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126268
更新日期:1992-10-01 00:00:00
abstract::After in vivo treatment, progesterone initially decreases tyrosine hydroxylase (TH) activity in the TIDA neurons, but subsequently increases TH activity with prolonged treatment. In order to explore the cellular mechanism for progesterone's effect, this study examined the acute inhibitory action of progesterone on TH ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000057336
更新日期:2002-05-01 00:00:00
abstract::Plasma and hypothalamic LHRH was measured by specific radioimmuno-assay in intact and ovariectomized rats, and the values were correlated with peripheral plasma (PP) FSH and LH titers. At most stages of the estrous cycle, plasma LHRH was either undetectable or present at very minimal values. An increase in PP LHRH con...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122496
更新日期:1976-01-01 00:00:00
abstract::The effects of angiotensin II (AII) and natriuretic peptide (ANP), alone or in combination, on tuberoinfundibular dopaminergic (TIDA) neuronal activity and on serum PRL levels were examined in this study. The TIDA neuronal activity was determined by measuring 3,4-dihydroxyphenylacetic acid (DOPAC) concentration in the...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127254
更新日期:1997-11-01 00:00:00
abstract::The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126186
更新日期:1992-06-01 00:00:00
abstract::The hypothalamic preoptic area (POA) was electrically stimulated through permanently implanted electrodes in 4 unanesthetized sheep. Initiation of POA stimulation was followed witin 10-20 min by large increases in plasma levels of prolactin (PRL). The stimulation-induced discharges of PRL were consistently observed in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122384
更新日期:1975-01-01 00:00:00
abstract::Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing's syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone resorption, and alters the secretion of gonadotropin and gr...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000314298
更新日期:2010-01-01 00:00:00
abstract::Activin A immunoreactivity has been localized within the nucleus tractus solitarius and its projections into regions of the hypothalamus such as the paraventricular nucleus. However, the function of activin within the central nervous system is unclear. Because these regions of the brain are involved in the regulation ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126399
更新日期:1993-03-01 00:00:00
abstract::The ability of dopamine receptor antagonists to stimulate prolactin release in rats with medial basal hypothalamic lesions was investigated. Starting levels of prolactin were elevated to approximately 400 ng/ml in animals in which the tuberoinfundibular dopaminergic neurons were completely destroyed by the lesion. In ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123188
更新日期:1981-06-01 00:00:00
abstract::Unlike rats, but similar to primates, guinea pigs exhibit prolonged function of the corpus luteum and elevated progesterone secretion after ovulation. The gonadotropins, estrogen (E) and progesterone (P) have been examined throughout the guinea pig estrous cycle. However, neither prolactin secretion nor its regulation...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126897
更新日期:1995-06-01 00:00:00
abstract:UNLABELLED:Mediobasal hypothalamic slices of adult ovariectomized (OVX) rats treated or not with 17 beta-estradiol (E2) were superfused in buffered (pH 7.2) Locke medium containing bacitracin. A 6-min pulse of K+ (56 m M) was less effective in releasing luteinizing hormone releasing hormone (LH-RH) from mediobasal hypo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123883
更新日期:1984-02-01 00:00:00
abstract::The mu-opioid receptor (OR) is involved in several aspects of female reproductive neuroendocrinology, such as the control of gonadotropin release and the display of lordosis behavior. Even though the neuroendocrine events modulated by mu-ORs are steroid hormone-dependent, few studies have shown how steroid hormones su...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000065953
更新日期:2002-10-01 00:00:00
abstract::Immunoreactive thyroid-stimulating hormone (IR-TSH) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. Recently, immunocytochemical studies have revealed that IR-TSH is present in thyrotropes in the pars tuberalis. Therefore, because these th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124149
更新日期:1985-07-01 00:00:00
abstract::Using two tests in intact adult rats, it has been found that a high positive correlation exists (p less than 0.005) between the ovulation inhibiting and the serotonin antagonistic activities measured in vivo of five tricyclic compounds and ten ergot derivatives. In these chemically different classes of compounds, cert...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123005
更新日期:1980-04-01 00:00:00
abstract::The effect of sonicated suspensions of phosphatidylserine (PS), an acidic phospholipid, was investigated on prolactin secretion utilizing in vivo and in vitro approaches. Acute and chronic administration of PS reduced plasma prolactin levels during different phases of circadian rhythms. The phospholipid was able to in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123261
更新日期:1981-12-01 00:00:00
abstract::The orphanin-FQ/nociceptin (OFQ/N) receptor (previously, ORL1, LC132) has been shown to be coupled to an inwardly rectifying K+ conductance in several neuronal populations. Although OFQ/N receptor mRNA is densely expressed in the supraoptic nucleus (SON), little is known about its coupling to effector system(s). The p...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054441
更新日期:1999-05-01 00:00:00
abstract::This study was carried out to clarify the central effects of neuropeptide Y (NPY) on gonadotropin and prolactin (PRL) release in the male rat and to evaluate the hypothesis that it may play a role in negative feedback regulation of gonadotropin secretion in the male. NPY (4 micrograms in 2 microliters 0.9% NaCl) or an...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126481
更新日期:1993-06-01 00:00:00
abstract:INTRODUCTION:The pituitary gland has a high expression of somatostatin receptors (SSTRs) and is therefore a potential organ at risk for radiation-induced toxicity after 177Lu-DOTATATE treatment. OBJECTIVE:To study changes in pituitary function in patients with neuroendocrine tumors (NETs) treated with dosimetry-based ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000507761
更新日期:2020-04-08 00:00:00
abstract::Avian prolactin (PRL) secretion is regulated by vasoactive intestinal peptide (VIP) neurons residing in the infundibular nuclear complex (INF) of the hypothalamus. This VIPergic activity is modulated by stimulatory dopaminergic inputs. Dynorphin, serotonin (5-HT), dopamine (DA) and VIP all appear to stimulate PRL secr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000048236
更新日期:2002-03-01 00:00:00
abstract::The capability of the anterior pituitary gland to secrete growth hormone (GH) in response to an intravenous injection of growth hormone-releasing factor, hpGRF-44, was evaluated in male rats ranging from 22 days to 24 months of age. The increase in GH concentrations following a submaximal dose of hpGRF-44 (0.5 microgr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123594
更新日期:1983-12-01 00:00:00