Abstract:
BACKGROUND:Kisspeptins are recognized as important stimulators of gonadotropin-releasing hormone (GnRH) and gonadotropin secretion. In sheep, the nonbreeding (anestrous) period is characterized by reduced Kiss1 mRNA expression in the hypothalamus. The aim of the present study was to determine whether the response to kisspeptin treatment varies between the breeding and nonbreeding seasons. METHODS:Corriedale ewes were treated intravenously with murine kisspeptin-10 (submaximal dose: 20 microg or maximal dose: 250 microg) or GnRH (250 ng) during either the anestrous period or during the breeding season at the luteal, mid-follicular, or late-follicular phase of the estrous cycle. RESULTS:Kisspeptin treatment increased the concentration of luteinizing hormone (LH) in all animals. We found the LH response to kisspeptin (20 microg) was greater in ewes during the anestrous period, being 4-fold that seen during the luteal phase of the estrous cycle. Within the breeding season, kisspeptin (20 microg) was most effective during the late-follicular phase of the estrous cycle. Kisspeptin treatment (both 20 and 250 microg) had no effect on plasma levels of growth hormone, prolactin or cortisol. The variable effect of kisspeptin (20 microg) on LH secretion appeared to mirror that of GnRH treatment indicating that the effect may be mediated by a change in the pituitary response to GnRH. CONCLUSION:We conclude that the gonadotropic response to kisspeptin depends upon the reproductive status of the female.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Smith JT,Saleh SN,Clarke IJdoi
10.1159/000227806subject
Has Abstractpub_date
2009-01-01 00:00:00pages
283-91issue
3eissn
0028-3835issn
1423-0194pii
000227806journal_volume
90pub_type
杂志文章abstract::The following fragments of LHRH were administered intraventricularly and tested for their ability to enhance sexual receptivity in ovariectomized, estrogen-primed female rats: LHRH1-6 NH2, Ac-LHRH5-10, des-Tyr5-LHRH and des-Gly10-LHRH. LHRH1-6 NH2 had no effect on sexual behavior compared to saline-infused controls. A...
journal_title:Neuroendocrinology
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更新日期:1983-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1983-11-01 00:00:00
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doi:10.1159/000126989
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更新日期:2004-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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更新日期:1989-01-01 00:00:00
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doi:10.1159/000124991
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pub_type: 杂志文章
doi:10.1159/000122372
更新日期:1975-01-01 00:00:00
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doi:10.1159/000123107
更新日期:1980-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000122803
更新日期:1978-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:1996-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000507761
更新日期:2020-04-08 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123211
更新日期:1981-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-05-04 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126743
更新日期:1994-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-09-01 00:00:00