Abstract:
BACKGROUND:Type I gastric carcinoids (TIGCs) are neuroendocrine neoplasms arising from enterochromaffin-like cells in atrophic body gastritis. Data regarding their evolution in prospective series are scarce, thus treatment and follow-up are not codified. Our aim was to evaluate clinical outcome and recurrence in TIGCs managed by endoscopic approach. METHODS:33 patients (24 females; median age 65 years, range 23-81) were included and managed through endoscopic follow-up every 6-12 months, with lesion removal and multiple gastric biopsies. Baseline clinical and histological features were analyzed as risk factors by Cox regression. RESULTS:At diagnosis, 7 tumors were intramucosal carcinoids and 26 were polyps (median diameter 5 mm, range 2-20), multiple in 17 patients. Associated severe atrophy was present in 21 cases (63.6%), while mild atrophy was found in 6 cases (18.2%). During a 46-month median follow-up, survival was 100% and no metastases occurred. One patient developed a less-differentiated carcinoid that was radically treated by surgery. 21 patients (63.6%) had recurrence after a median of 8 months, 14 of these (66.6%) had a second recurrence after a median of 8 months following the previous carcinoid removal. Median recurrence-free survival was 24 months. Neither clinical nor biochemical recurrence-predicting factors were found. CONCLUSIONS:Although about 60% of TIGCs had recurrence after endoscopic resection, endoscopic management may be considered safe and effective.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Merola E,Sbrozzi-Vanni A,Panzuto F,D'Ambra G,Di Giulio E,Pilozzi E,Capurso G,Lahner E,Bordi C,Annibale B,Delle Fave Gdoi
10.1159/000329043subject
Has Abstractpub_date
2012-01-01 00:00:00pages
207-13issue
3eissn
0028-3835issn
1423-0194pii
000329043journal_volume
95pub_type
杂志文章abstract::In previous studies we demonstrated that insulin-like growth factor I (IGF-I) induces pituitary vasoactive intestinal peptide (VIP) gene expression and secretion, and that IGF-I-induced prolactin (PRL) release is mediated by VIP. In this study, we investigate the mitotropic action of IGF-I and VIP on pituitary lactotr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000070900
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abstract::Neuronal nitric oxide synthase, e.g. NADPH diaphorase (NADPH-d), catalyzes formation of the free radical, nitric oxide (NO), and occurs within brain structures that have functional significance for energy fuel homeostasis. The following studies examined whether populations of NADPH-d-positive neurons in the hypothalam...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054417
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abstract::In the Siberian hamster the pituitary content of bioassayable MSH has been shown to be seasonally variable, being greater during the long days of spring and summer than during the short days of autumn and winter. Similar changes in the pituitary content of both bioassayable MSH and immunoreactive alpha MSH can be indu...
journal_title:Neuroendocrinology
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doi:10.1159/000123019
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124241
更新日期:1986-01-01 00:00:00
abstract::Dexras1, a newly identified member of the Ras superfamily of proteins, was discovered in AtT-20 corticotrope cells because its expression was induced in response to glucocorticoids (dexamethasone; Dex). As yet, the function of Dexras1 is unknown, but its rapid induction in response to glucocorticoids suggests the poss...
journal_title:Neuroendocrinology
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doi:10.1159/000054691
更新日期:2001-10-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126717
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journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126940
更新日期:1996-01-01 00:00:00
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124946
更新日期:1988-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1993-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000079752
更新日期:2004-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124799
更新日期:1987-06-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122924
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126125
更新日期:1992-03-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:2001-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123413
更新日期:1982-11-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125153
更新日期:1989-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125612
更新日期:1990-10-01 00:00:00