Abstract:
:Grafts of normal mouse preoptic area (POA) tissue into the third ventricle of gonadotrophin-releasing hormone (GnRH)-deficient hypogonadal (hpg) mice resulted in an elevation of pituitary GnRH receptors, an increased synthesis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland, an elevation of gonadal LH receptors and in the stimulation of steroidogenesis and spermatogenesis in the testis. In normal mice both castration or the subcutaneous implantation of testosterone capsules for 10 days reduced GnRH receptors, pituitary LH and FSH content, and the latter treatment also caused a 50% reduction in testicular LH receptors. In hpg mice bearing POA grafts testosterone implants failed to affect any of the above parameters, and castration failed to affect pituitary gonadotrophin hormone content, although there was a slight reduction in pituitary GnRH receptors after castration. These experiments suggest that neither the pituitary gonadotroph, nor the GnRH neurone represent major sites for the direct negative feedback of testosterone upon gonadotrophic hormone secretion in male mice.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Charlton HM,Jones AJ,Ward BJ,Detta A,Clayton RNdoi
10.1159/000124762subject
Has Abstractpub_date
1987-05-01 00:00:00pages
376-80issue
5eissn
0028-3835issn
1423-0194journal_volume
45pub_type
杂志文章abstract::The pineal gland in the rat exhibits a diurnal rhythm in activity of the enzyme serotonin N-acetyltransferase (N-AT) with peak values during the dark period of a diurnal lighting schedule approximately 100-fold those during the light period. After blinding the rhythm becomes free-running. It is abolished by partial hy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122489
更新日期:1976-01-01 00:00:00
abstract::Brain corticosteroid receptors, the type 1 mineralocorticoid receptor (MR) and the type 2 glucocorticoid receptor (GR), are involved in the regulation of neuroendocrine and behavioral responses during ongoing and stressful conditions. To further investigate the role of MR in these responses, we treated male Wistar rat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127272
更新日期:1997-03-01 00:00:00
abstract::The worldwide obesity epidemic is increasing, yet at this time, no long-acting and specific pharmaceutical therapies are available. Peripheral hormonal signals communicate metabolic status to the hypothalamus by activating their corresponding receptors in the arcuate nucleus (ARC). In this brain region, a variety of G...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000334903
更新日期:2012-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125920
更新日期:1991-10-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:2004-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054351
更新日期:1998-07-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126989
更新日期:1995-07-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124562
更新日期:1986-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章
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更新日期:2003-07-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123248
更新日期:1981-11-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124998
更新日期:1988-08-01 00:00:00
abstract::The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125536
更新日期:1990-07-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123299
更新日期:1982-03-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000350790
更新日期:2013-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127113
更新日期:1996-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126869
更新日期:1995-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126418
更新日期:1993-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1988-09-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509091
更新日期:2020-06-03 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054685
更新日期:2001-09-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000430819
更新日期:2016-01-01 00:00:00
abstract::In the Djungarian hamster Phodopus sungorus, the daily temporal pattern of synthesis and release of pineal hormone melatonin, mainly the length of the period of elevated melatonin levels, may be involved in transferring the information on day length to the neuroendocrine-gonadal axis. The present study investigated th...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123895
更新日期:1984-03-01 00:00:00
abstract::Many aspects of reproductive neuroendocrine function and sexual behavior are responsive to both androgens and estrogens, suggesting that receptors for these steroid hormones may reside within single cells in brain regions that control reproductive function. We determined the distribution of estrogen receptor-containin...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127039
更新日期:1995-11-01 00:00:00
abstract::Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000321395
更新日期:2010-01-01 00:00:00