Diurnal variation in hypothalamic monoamines and plasma corticosterone in the turkey after inhibition of tyrosine hydroxylase or tryptophan hydroxylase.

Abstract:

:Circadian rhythms occur in hypothalamic serotonin content in the turkey. Inhibition of serotonin (5-HT) synthesis by parachlorophenylalanine (PCPA) blocks circadian variation in hypothalamic serotonin levels suggesting that the major cause of diurnal fluctuations is differing rates of synthesis of the amine. PCPA treatment also abolishes the diurnal rhythm in plasma corticosterone and elevates the basal levels of this steroid suggesting that 5-HT terminals in the hypothalamus may inhibit the release of ACTH at certain times of the day and in this fashion generate diurnal fluctuations in plasma corticosterone. Hypothalamic levels of dopamine (DA) and norepinephrine (NE) also vary diurnally, and synthesis inhibition with alpha-methyl-para-tyrosine abolishes the diurnal rhythm in NE but not DA or in plasma corticosterone. Temporal changes in release and/or degradation of DA are significant factors contributing to the diurnal rhythms of this amine in the hypothalamus. Diurnal fluctuations in plasma corticosterone do not depend on recent synthesis of catecholamines.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Martin JT,El Halawani M,Phillips RE

doi

10.1159/000123299

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

191-6

issue

3

eissn

0028-3835

issn

1423-0194

journal_volume

34

pub_type

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