Abstract:
:Observations in experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis (MS), have indicated that a low activity of the hypothalamo-pituitary-adrenal (HPA) system is accompanied by a high susceptibility for EAE in rat strains and that elevated corticosteroid levels are necessary for spontaneous recovery from EAE. The HPA axis activity is regulated by both corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP). Both types of neurons are localized in the paraventricular nucleus (PVN) of the hypothalamus. We determined the number of immunocytochemically identified CRH-immunoreactive (CRH-IR) and AVP-immunoreactive (AVP-IR) neurons in the PVN of the human hypothalamus of 8 MS patients, aged 34-63 years, and 8 age-matched control subjects without any primary neurological or psychiatric disorders, aged 30-59 years. In addition, the number of oxytocin (OXT) immunoreactive (OXT-IR) neurons was determined, since these neurons innervate brain stem nuclei and might thus be related to autonomic disturbances in MS. In MS the staining intensity for AVP was clearly lower and for OXT slightly lower. For CRH, the staining intensity was similar in both groups, and, moreover, in MS patients the number of CRH-IR cells in the PVN was found to be about 2.4 times higher than that in the control group. The number of OXT-IR or AVP-IR cells in the PVN of MS patients was not significantly different from that of the control group. Our results point to an activation of the neuroendocrine HPA axis which may be compatible with the idea that the HPA axis is involved in recovery from MS.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Purba JS,Raadsheer FC,Hofman MA,Ravid R,Polman CH,Kamphorst W,Swaab DFdoi
10.1159/000126989subject
Has Abstractpub_date
1995-07-01 00:00:00pages
62-70issue
1eissn
0028-3835issn
1423-0194journal_volume
62pub_type
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journal_title:Neuroendocrinology
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doi:10.1159/000124714
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
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doi:10.1159/000126930
更新日期:1996-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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更新日期:2020-06-22 00:00:00
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pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126706
更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000123933
更新日期:1984-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126799
更新日期:1994-12-01 00:00:00
abstract::The present study was aimed at evaluating chronic stress models in mice with special attention to morphine treatment. We hypothesized that repeated periods of drug withdrawal induce chronic stress. To verify this hypothesis, mice were made dependent on morphine and then subjected to several types of repeated withdrawa...
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00