Abstract:
:Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2(-/-)) puts forward new insights into the role of the D2R in growth hormone (GH)-releasing hormone-GH regulation, peptides involved in food intake, glucose homeostasis, as well as in prolactinoma development. The expected phenotype of chronic hyperprolactinemia and prolactinoma development was found in the Drd2(-/-) mouse, and this model constitutes a valuable tool in the study of dopamine-resistant prolactinomas. Unexpectedly, these mice were growth retarded, and the importance of functional hypothalamic D2Rs in the neonatal period was revealed. In the Drd2(-/-) mouse there was a failure of high neonatal GH levels and therefore the expansion of pituitary somatotropes was permanently altered. These mice also had increased food intake, and a sexually dimorphic participation of the D2R in food intake regulation is suggested. The effect described is probably secondary to D2R regulation of prolactin secretion. Furthermore, the negative modulation of D2Rs on α-melanocyte-stimulating hormone release and positive action on the hypothalamic expression of orexins reveals the complex D2R regulation of food intake. Finally, pancreatic D2Rs inhibit glucose-stimulated insulin release. Lack of dopaminergic inhibition throughout development in the Drd2(-/-) mouse may exert a gradual deteriorating effect on insulin homeostasis, so that eventually glucose intolerance develops. These results highlight the complex endocrine actions of the D2Rs at different levels, hypothalamus, pituitary or pancreas, which function to improve fitness, reproductive success and survival.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Garcia-Tornadú I,Perez-Millan MI,Recouvreux V,Ramirez MC,Luque G,Risso GS,Ornstein AM,Cristina C,Diaz-Torga G,Becu-Villalobos Ddoi
10.1159/000321395subject
Has Abstractpub_date
2010-01-01 00:00:00pages
207-14issue
4eissn
0028-3835issn
1423-0194pii
000321395journal_volume
92pub_type
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journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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更新日期:2003-01-01 00:00:00
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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更新日期:1980-10-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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更新日期:2002-11-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:2020-05-04 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123389
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doi:10.1159/000124049
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journal_title:Neuroendocrinology
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更新日期:1991-06-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1982-03-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122865
更新日期:1979-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124479
更新日期:1986-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124748
更新日期:1987-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126995
更新日期:1995-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000084872
更新日期:2005-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125612
更新日期:1990-10-01 00:00:00