Abstract:
:Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters and neuromodulators. The study of the circadian organization of neuroendocrine functions may be considered a clinically reliable tool to investigate the changes of the CNS and particularly of the limbic-hypothalamic system occurring in aged people. The circadian rhythms of plasma melatonin, ACTH and cortisol and of oral temperature were studied in 16 clinically healthy women aged 66-90 years and in 14 young controls aged 20-30. In addition, the effect of dexamethasone on the plasma cortisol circadian rhythm and the cortisol response to Synacthen pulse intravenous injection were evaluated. All subjects were studied as inpatients, with the same synchronization to the hospital life schedule. When compared with young controls, elderly subjects exhibited a reduction of the mean level and of the amplitude of the circadian rhythm of oral temperature, an increase of the mean level of ACTH and cortisol rhythms and a selective impairment of melatonin nocturnal secretion. Furthermore, elderly subjects showed a reduced sensitivity to the dexamethasone suppression test, by comparison to young controls. These changes were age-related and they may depend either on CNS modification or on alterations of the hormonal metabolic clearance.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Ferrari E,Magri F,Dori D,Migliorati G,Nescis T,Molla G,Fioravanti M,Solerte SBdoi
10.1159/000126869subject
Has Abstractpub_date
1995-04-01 00:00:00pages
464-70issue
4eissn
0028-3835issn
1423-0194journal_volume
61pub_type
杂志文章abstract::This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127113
更新日期:1996-08-01 00:00:00
abstract::The effects of corticotropin-releasing factor (CRF) on GnRH release from the adult male rat mediobasal hypothalamus (MBH) and median eminence (ME) were studied in an in vitro incubation system. CRF induced a dose-related inhibition of GnRH release from both the MBH and the isolated ME, and this inhibition was blocked ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124578
更新日期:1986-01-01 00:00:00
abstract::The sheep exhibits a marked sex difference in the timing of the pubertal increase in luteinizing hormone (LH). Male lambs undergo a reduction in sensitivity to inhibitory steroid feedback, leading to an increase in LH by 10 weeks of age, but females remain hypersensitive until 30 weeks of age. Endogenous opioids suppr...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126312
更新日期:1992-12-01 00:00:00
abstract::Intracranial implants of estradiol benzoate (EB) were used to explore sites of action for the activation of masculine copulatory behavior in castrated male rats. In experiment 1, 27 or 30 gauge implants were placed unilaterally throughout the hypothalamus and preoptic area. Dihydrotestosterone (DHT) was administered s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122865
更新日期:1979-01-01 00:00:00
abstract::Estradiol (E2) and progesterone (P4) interact to influence tuberoinfundibular dopaminergic neuronal activity and contribute to the control of prolactin (PRL) release. This study examined tyrosine hydroxylase mRNA signal levels in the arcuate nucleus of the hypothalamus and tyrosine hydroxylase activity in the stalk-me...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126583
更新日期:1993-11-01 00:00:00
abstract::The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123957
更新日期:1984-07-01 00:00:00
abstract::The ligand specificities of sites binding tritium-labeled arginine vasopressin (3H-AVP) were investigated in membrane preparations of rat anterior pituitary gland and liver. Labeled AVP interacted with high-affinity, low-capacity binding sites in liver as well as in pituitary membrane fractions. Binding displacement s...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123976
更新日期:1984-08-01 00:00:00
abstract:AIM:To extensively explore microRNA expression profiles in lung carcinoids in correlation with clinical and pathological features. METHODS:A PCR-based array was employed in the screening phase to analyze 752 microRNAs in a discovery set of 12 lung carcinoids, including 6 typical (3 with lymph node metastasis) and 6 at...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000381454
更新日期:2015-01-01 00:00:00
abstract::Leptin exerts important effects on the regulation of food intake and energy expenditure by acting in the brain. Leptin action is mediated by the interaction with a receptor that is alternatively spliced, resulting in at least five different isoforms. The long form (OB-Rb) has a long intracellular domain that is essent...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054536
更新日期:2000-03-01 00:00:00
abstract::Grafts of normal mouse preoptic area (POA) tissue into the third ventricle of gonadotrophin-releasing hormone (GnRH)-deficient hypogonadal (hpg) mice resulted in an elevation of pituitary GnRH receptors, an increased synthesis of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland, a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124762
更新日期:1987-05-01 00:00:00
abstract::Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,0...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125071
更新日期:1988-12-01 00:00:00
abstract::To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...
journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1159/000122753
更新日期:1978-01-01 00:00:00
abstract::The role of endogenous corticoids in fever responses caused by recombinant murine interleukin (IL)-1 beta and IL-6 was studied in adult male Wistar rats. Adrenalectomy diminished the development of fever after intracerebroventricular (icv) injection of these ILs and lowered body temperature. Intraperitoneal administra...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126682
更新日期:1994-04-01 00:00:00
abstract::Reliable prediction of disease status is a major challenge in managing gastroenteropancreatic neuroendocrine tumors (GEP-NET). The aim of the study was to validate the NETest®, a blood molecular genomic analysis, for predicting the course of disease in individual patients compared to Chromogranin A (CgA). NETest® (nor...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509091
更新日期:2020-06-03 00:00:00
abstract::Endogenous gonadoliberin was localized by using immunocytological methods in the hypothalamic neurons which synthetize the peptide and in the hypophysial target cells. The rat tissues were fixed and frozen. Ultrathin sections were obtained by cryoultramicrotomy. In the pituitary gland, GnRH was observed in both gonado...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123300
更新日期:1982-03-01 00:00:00
abstract::Interleukin-1 (IL-1) and glucocorticoid hormones represent two key mediators involved in the modulation of the neuroimmunoendocrine response to stress. IL-1 is a potent activator of the hypothalamic-pituitary-adrenal (HPA) axis in rodents. In the immune system, glucocorticoids modulate IL-1 production and a number of ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126648
更新日期:1994-02-01 00:00:00
abstract::Vasostatin, a fragment of calreticulin, was transfected in the BON cell line to evaluate the feasibility of using it for gene therapy in neuroendocrine tumors. Vasostatin transfected cells were subcutaneously inoculated in nude mice. Burkitt lymphoma cell line, CA46, colorectal adenocarcinoma cell line, SW480, as well...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000089749
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:A mammalian circannual pacemaker responsible for regulating the seasonal pattern of prolactin has been recently described in sheep. This pacemaker resides within the pars tuberalis, an area of the pituitary gland that densely expresses melatonin receptors. However, the chemical identity of the cell type...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000350790
更新日期:2013-01-01 00:00:00
abstract::Pierre Marie coined the term 'acromegaly' in 1886 and linked it to a distinct clinical disease with a characteristic clinical picture. However, Pierre Marie was not the first physician to give a full record of the clinical picture of acromegaly; others had preceded him, like the Dutch physician Johannes Wier. After Ma...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000371808
更新日期:2016-01-01 00:00:00
abstract::Normal and castrated male rats implanted with permanent right atrial cannulae were used, and sequential blood samples were taken every 2 min through the cannula. When the rats, both normal and castrated, were exposed to ether for 2 min, the prolactin (Prl) concentration in plasma was immediately and dramatically eleva...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122826
更新日期:1978-01-01 00:00:00
abstract::Introduction The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol on arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000509583
更新日期:2020-06-22 00:00:00
abstract::Sexual behavior and elevation of gonadal steroids were induced in both male and female New Zealand white rabbits following injection of synthetic beta (1-24) ACTH into the lateral cerebral ventricle. In blood assays collected by cardiac puncture, testosterone, progesterone and corticosterone were all increased above b...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122441
更新日期:1975-01-01 00:00:00
abstract::Structural and functional impairment of the skeletal system remains an important cause of morbidity and disability in patients with Cushing's syndrome (CS). Glucocorticoid (GC) excess inhibits bone formation and calcium absorption from the gut, increases bone resorption, and alters the secretion of gonadotropin and gr...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000314298
更新日期:2010-01-01 00:00:00
abstract::A number of neurochemical messengers have been shown to act directly on the melanotrope cells of the pars intermedia of Xenopus laevis to regulate alpha MSH secretion. In the present study the possibility that the melanotropes are also indirectly controlled has been examined. For this purpose, the characteristics of a...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125853
更新日期:1991-07-01 00:00:00
abstract::The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123011
更新日期:1980-05-01 00:00:00
abstract::Diurnal variations, ranging over a twofold difference in concentrations of dopamine, norepinephrine and epinephrine, occur in the rat posterior pituitary gland during a 24-hour period. Highest catecholamine concentrations were seen during daylight hours and low levels reached a nadir 5 h after the onset of darkness. D...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123292
更新日期:1982-02-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the patho...
journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000455233
更新日期:2017-01-01 00:00:00
abstract::Histamine (HA) stimulates the release of the pro-opiomelanocortin (POMC)-derived peptides ACTH, beta-endorphin (beta-END), beta-lipotropin and alpha-melanocyte-stimulating hormone, and HA is involved in the mediation of the stress-induced release of these peptides. The effect of HA is indirect and may involve the hypo...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126258
更新日期:1992-09-01 00:00:00
abstract::A significant increase of cell multiplication in inoculated ascitic and solid tumors was demonstrated in both DBA/2 and C57BL/6 mice as well as in Wistar rats after radiofrequency lesions in the median hypothalamus (ventromedial and dorsomedial nuclei; part of arcuate nucleus). The following tests were performed: mito...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124479
更新日期:1986-01-01 00:00:00
abstract::In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125777
更新日期:1991-06-01 00:00:00