Blood Molecular Genomic analysis predicts the disease course of GEP NET patients: a validation study of the predictive value of the NETest®.

abstract：:Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...

journal_title：Neuroendocrinology

authors： Arey BJ,Kanyicska B,Freeman ME

更新日期：1991-01-01 00:00:00

abstract：:Previous reports have shown that dopamine (DA) in the zona incerta (ZI) has a stimulatory effect on gonadotrophin release. We have now investigated the possibility that steroids exert their feedback effects on the release of luteinizing hormone (LH) via catecholamine systems in the ZI. Since the same steroid regimes a...

journal_title：Neuroendocrinology

authors： Wilson CA,James MD,Grierson JP,Hole DR

更新日期：1991-02-01 00:00:00

abstract：:To determine whether the inhibitory effect of clonidine (CLON) on renin secretion is due in part to a direct action on the kidneys or due entirely to an action on the brain, the drug was administered intravenously in a dose of 30 microgram/kg to dogs in which the spinal cord had been transected in the cervical region....

journal_title：Neuroendocrinology

authors： Ganong WF,Wise BL,Reid IA,Holland J,Kaplan S,Shackelford R,Boryczka AT

更新日期：1978-01-01 00:00:00

abstract：:The effects of linear (L) or cyclic (C) somatostatin (SRIF) on the release of growth hormone (GH) as measured both by bioassay and by radioimmunoassay (RIA) were studied in a series of incubation experiments with rat adenohypophyses. Although both forms of SRIF inhibited release of RIA-GH in all experiments, only C-SR...

journal_title：Neuroendocrinology

authors： Russell SM

更新日期：1981-08-01 00:00:00

abstract：:To clarify the role and site of action of gamma-aminobutyric acid (GABA) in ovine pineal glands, we have investigated the effects of aminooxyacetic acid (AOAA), an inhibitor of GABA transaminase, on endogenous GABA content and beta-adrenoceptor mediated pineal function in Merino sheep. A significant elevation of endog...

journal_title：Neuroendocrinology

authors： Foldes A,Maxwell CA,Rintoul AJ,Edols RW

更新日期：1984-03-01 00:00:00

abstract：:In vivo single-unit extracellular recording was used to assess neuronal membrane sensitivity at the level of the midbrain central gray (MCG) to the iontophoresis of luteinizing hormone releasing hormone (LHRH) and beta-endorphin (beta-END). The percentage of change in firing rate was evaluated to determine the effect ...

journal_title：Neuroendocrinology

authors： Schiess MC,Dudley CA,Moss RL

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Carboplatin-etoposide (CarboEtop) is a 1st-line option for patients with advanced extra-pulmonary (EP), poorly-differentiated (PD) neuroendocrine carcinoma (NEC). Different schedules are used in clinical practice and randomised evidence is lacking. OBJECTIVES:To provide real-life outcomes of carboplatin com...

journal_title：Neuroendocrinology

authors： Frizziero M,Spada F,Lamarca A,Kordatou Z,Barriuso J,Nuttall C,McNamara MG,Hubner RA,Mansoor W,Manoharan P,Fazio N,Valle JW

更新日期：2019-01-01 00:00:00

abstract：:Hyponatremia due to elevated arginine vasopressin (AVP) secretion increases mortality in liver failure patients. The mechanisms causing dysregulation of AVP secretion are unknown. Our hypothesis is that inappropriate AVP release associated with liver failure is due to increased brain-derived neurotrophic factor (BDNF)...

journal_title：Neuroendocrinology

authors： Balapattabi K,Little JT,Bachelor M,Cunningham JT

更新日期：2020-01-01 00:00:00

abstract：:Insulin-deficient states are associated with an impaired function of the hypothalamic-pituitary-gonadal axis, but the mechanisms underlying hypothalamic alterations in experimental diabetes are still unknown. We investigated the effect of glucose concentrations, in the presence and absence of insulin, on LHRH release ...

journal_title：Neuroendocrinology

authors： Arias P,Rodríguez M,Szwarcfarb B,Sinay IR,Moguilevsky JA

更新日期：1992-09-01 00:00:00

abstract：:The effect of aging on the release of gonadotropin-releasing hormone (GnRH) in vitro and of luteinizing hormone (LH) both in vivo and in vitro in ovariectomized (Ovx) rats was studied. Old (21-24 months) and young (3-4 months) rats were Ovx before use. They were injected subcutaneously with estradiol benzoate (25 micr...

journal_title：Neuroendocrinology

authors： Hwang C,Pu HF,Hwang CY,Liu JY,Yao HC,Tung YF,Wang PS

更新日期：1990-08-01 00:00:00

abstract：:Ghrelin is a 28-amino-acid gastric peptide that potently stimulates growth hormone (GH) secretion in vivo and in vitro. Ghrelin-expressing cells have been found in the oxyntic region of the stomach and in the arcuate nucleus of the hypothalamus. The aim of this work was to investigate the regional distribution and dev...

journal_title：Neuroendocrinology

authors： Torsello A,Scibona B,Leo G,Bresciani E,Avallone R,Bulgarelli I,Luoni M,Zoli M,Rindi G,Cocchi D,Locatelli V

更新日期：2003-02-01 00:00:00

abstract：:The effect of steroids on the two gonadotropin-releasing hormone (GnRH) forms present in the eel (mammalian GnRH, mGnRH and chicken GnRH-II, cGnRH-II), as well as on gonadotropin (GTH), was studied using specific radioimmunoassays. Female silver eels received chronic treatments with various steroids (estradiol, testos...

journal_title：Neuroendocrinology

authors： Montero M,Le Belle N,King JA,Millar RP,Dufour S

更新日期：1995-05-01 00:00:00

abstract：:The storage form of prolactin (PRL) was converted into the releasable form in the lactating rat pituitary gland within 10 min of suckling by 6 pups following 4-5 h of nonsuckling on postpartum day 13-14. The characteristics of the PRL discharge from the releasable pool into the circulation was then studied using a sti...

journal_title：Neuroendocrinology

authors： Grosvenor CE

更新日期：1984-07-01 00:00:00

abstract：:To further investigate the role of serotonin in human prolactin (Prl) secretion, serotonin antagonists have been administered to healthy volunteers in basal conditions and after pretreatment with the selective blocker of dopamine receptors, pimozide (Pim). Highly significant falls (p less than 0.001) in serum Prl were...

journal_title：Neuroendocrinology

authors： Ferrari C,Caldara R,Romussi M,Rampini P,Telloli P,Zaatar S,Curtarelli G

更新日期：1978-01-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) is localized in fibers in the noradrenergic nucleus locus ceruleus (LC) and alters LC discharge characteristics when administered centrally. To determine whether CRF functions as a neurotransmitter in the LC during stress, the effects of hemodynamic stress on LC discharge were comp...

journal_title：Neuroendocrinology

authors： Valentino RJ,Wehby RG

更新日期：1988-12-01 00:00:00

abstract：:In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...

journal_title：Neuroendocrinology

authors： Leposavic G,Cover PO,Buckingham JC

更新日期：1991-06-01 00:00:00

abstract：:Tyrosine hydroxylase activity in noradrenergic neurons of the locus coeruleus was found to rise in bilaterally adrenalectomized adult mice, with maximum increase of the enzyme activity (52% above control) occurring 7 days after the surgery. No such increase of tyrosine hydroxylase activity was found in dopaminergic ne...

journal_title：Neuroendocrinology

authors： Markey KA,Sze PY

更新日期：1984-04-01 00:00:00

abstract：:Hereditary cases of growth hormone (GH)-secreting tumors have been classified into three clinical entities: the multiple endocrine neoplasia type 1 (MEN1) syndrome, the Carney complex (CNC) and the isolated familial somatotropinomas (IFS). The genomic defects associated with MEN1 are all linked to various mutations of...

journal_title：Neuroendocrinology

authors： Lytras A,Tolis G

更新日期：2006-01-01 00:00:00

abstract：:The concentrations in plasma of the biologically active endogenous peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) have not been measured during development or in female rats. By radioimmunoassay, we found that Tyr-MIF-1-like immunoreactivity (Tyr-MIF-1-LI) was first consistently detectable in plasma when the rat was 5 days o...

journal_title：Neuroendocrinology

authors： Kastin AJ,Fabre L,Brown MM,Olson RD

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Manipulating thyroid hormones has been shown to influence learning and memory. Although a large body of literature is available on the effects of thyroid hormone deficiency on learning and memory functions during developmental or adult-onset hypothyroidism, electrophysiological findings are limited. This lim...

journal_title：Neuroendocrinology

authors： Taşkın E,Artis AS,Bitiktas S,Dolu N,Liman N,Süer C

更新日期：2011-01-01 00:00:00

abstract：:TRPM8 is a member of the melastatin-type transient receptor potential ion channel family. Activation by cold or by agonists (menthol, icilin) induces a transient rise in intracellular free calcium concentration ([Ca(2+)](i)). Our previous study demonstrated that Ca(2+)-permeable cation channels play a role in IGF-1-in...

journal_title：Neuroendocrinology

authors： Mergler S,Strowski MZ,Kaiser S,Plath T,Giesecke Y,Neumann M,Hosokawa H,Kobayashi S,Langrehr J,Neuhaus P,Plöckinger U,Wiedenmann B,Grötzinger C

更新日期：2007-01-01 00:00:00

abstract：:Pit-1 expression has been reported to be cell-type-specific in the adult human pituitary and in human pituitary adenomas. In contrast, studies of rodent fetal adenohypophysial development as well as mature rodent glands have indicated that the pit-1 mRNA is ubiquitously expressed and the protein is under translational...

journal_title：Neuroendocrinology

authors： Puy LA,Asa SL

更新日期：1996-04-01 00:00:00

abstract：:We studied the effects of selected leukotrienes and hydroxyeicosatetraenoic acids (HETEs) on prolactin release from primary cultures of female rats anterior pituitary cells. Leukotrienes B4, C4, and D4 had no effect on basal prolactin release; however, they did enhance prolactin release that was stimulated by 1 or 5 n...

journal_title：Neuroendocrinology

authors： Judd AM,Spangelo BL,Ehreth JT,MacLeod RM

更新日期：1988-10-01 00:00:00

abstract：:Observations in experimental allergic encephalomyelitis (EAE), a model for multiple sclerosis (MS), have indicated that a low activity of the hypothalamo-pituitary-adrenal (HPA) system is accompanied by a high susceptibility for EAE in rat strains and that elevated corticosteroid levels are necessary for spontaneous r...

journal_title：Neuroendocrinology

authors： Purba JS,Raadsheer FC,Hofman MA,Ravid R,Polman CH,Kamphorst W,Swaab DF

更新日期：1995-07-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the patho...

journal_title：Neuroendocrinology

authors： Chiu WL,Boyle J,Vincent A,Teede H,Moran LJ

更新日期：2017-01-01 00:00:00

abstract：:Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...

journal_title：Neuroendocrinology

authors： Badura LL,Goldman BD

更新日期：1992-04-01 00:00:00

abstract：:Over the last 10 years, kisspeptins--peptide products of varying lengths encoded by the KISS1 gene--have been found to be key regulators of normal reproductive function throughout life in animals and humans. By activating the kisspeptin receptor [previously known as orphan G protein-coupled receptor 54 (GPR54)], they ...

journal_title：Neuroendocrinology

authors： Prague JK,Dhillo WS

更新日期：2015-01-01 00:00:00

abstract：:Adenylate cyclase activity was studied in anterior pituitary homogenates from young adult (6 months) and old (20 and 24 months) male rats. Basal, NaF-, GTP-, 5'-guanylimidodiphosphate (Gpp(NH)p)- and forskolin-stimulated activities were similar in the three groups, implying that the stimulatory guanyl nucleotide regul...

journal_title：Neuroendocrinology

authors： Robberecht P,Gillard M,Waelbroeck M,Camus JC,De Neef P,Christophe J

更新日期：1986-01-01 00:00:00

abstract：UNLABELLED:Opioid peptides are present in both the posterior pituitary (PP) and stalk-median eminence (SME). Their effects on the dopaminergic neurons in the SME are well documented, but little is known concerning their role in the regulation of dopamine (DA) release from the PP. The objectives of this study were (1) t...

journal_title：Neuroendocrinology

authors： Garris PA,Ben-Jonathan N

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND/AIMS:Abuse of toluene products (e.g., glue-sniffing) primarily occurs during adolescence and has been associated with appetite suppression and weight impairments. However, the metabolic phenotype arising from adolescent inhalant abuse has never been fully characterised, and its persistence during abstinence ...

journal_title：Neuroendocrinology

authors： Crossin R,Andrews ZB,Sims NA,Pang T,Mathai M,Gooi JH,Stefanidis A,Oldfield BJ,Lawrence AJ,Duncan JR

更新日期：2018-01-01 00:00:00