Abstract:
:It has been well documented that interleukin-1beta (IL-1beta) is a major mediator for recruiting the hypothalamo-pituitary-adrenal (HPA) axis following infectious disease. The recent localization of IL-1beta receptors in neurons of the hippocampus provides further support for the role of IL-1beta as a neurotransmitter/neuromodulator in the central nervous system. In this study, we investigated whether an acute intrahippocampal injection of IL-1beta is able to rapidly stimulate HPA activity. Seven days after bilateral implantation of a guide cannula into the hippocampus, human IL-1beta (10 ng/0.5 microliter/side) was injected to freely moving male rats. Following this, animals were sacrificed at times 20, 45 and 90 min postinjection and a kinetic analysis of hIL-1beta action on plasma ACTH and corticosterone (CORT) concentrations and nuclear processing of the anterior pituitary (AP) proopiomelanocortin (POMC) was conducted. Intrahippocampal administration of hIL-1beta significantly increased both plasma ACTH and CORT concentrations at 45 and 90 min postinjection. This increase in ACTH concentration paralleled a rise in AP POMC gene transcription. Moreover, the increase in AP POMC primary transcript was followed by an increase in AP POMC intermediate processing RNA. However, at these times, no significant hIL-1beta effect on the level of AP nuclear POMC mRNA was observed. Almost identical results were obtained after intraperitoneal injection of hIL-1beta. In conclusion, our data demonstrates that the hippocampal IL-1beta/IL-1beta receptor is directly and rapidly implicated in HPA activation, in the same manner as that observed after intraperitoneal administration of hIL-1beta. These results show that IL-1 action in the hippocampus could be of immunoneuroendocrine significance for the HPA axis activation during inflammatory states.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Mélik Parsadaniantz S,Daugé V,Roques BP,Kerdelhué Bdoi
10.1159/000054405subject
Has Abstractpub_date
1999-02-01 00:00:00pages
77-87issue
2eissn
0028-3835issn
1423-0194pii
54405journal_volume
69pub_type
杂志文章abstract::The effects of linear (L) or cyclic (C) somatostatin (SRIF) on the release of growth hormone (GH) as measured both by bioassay and by radioimmunoassay (RIA) were studied in a series of incubation experiments with rat adenohypophyses. Although both forms of SRIF inhibited release of RIA-GH in all experiments, only C-SR...
journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
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doi:10.1159/000124914
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journal_title:Neuroendocrinology
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054429
更新日期:1999-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124714
更新日期:1987-02-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000126217
更新日期:1992-07-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000127039
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000066625
更新日期:2002-11-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1986-01-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000124103
更新日期:1985-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124164
更新日期:1985-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123413
更新日期:1982-11-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126399
更新日期:1993-03-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124049
更新日期:1985-01-01 00:00:00
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doi:10.1159/000054657
更新日期:2001-06-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125146
更新日期:1989-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124190
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1985-07-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123499
更新日期:1983-06-01 00:00:00
abstract::Characteristic increases in neuronal activity coincident with the pulsatile release of luteinizing hormone from the pituitary gland have been recorded from electrodes chronically implanted in the medial basal hypothalamus of the rhesus monkey. This electrophysiologic manifestation of the hypothalamic 'pulse generator'...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123988
更新日期:1984-09-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123326
更新日期:1982-01-01 00:00:00
abstract::The hypothalamic preoptic area (POA) was electrically stimulated through permanently implanted electrodes in 4 unanesthetized sheep. Initiation of POA stimulation was followed witin 10-20 min by large increases in plasma levels of prolactin (PRL). The stimulation-induced discharges of PRL were consistently observed in...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122384
更新日期:1975-01-01 00:00:00
abstract::The possible implication of the amygdaloid central nucleus (ACE) of the rat in the control of ACTH secretion in response to immobilization stress was assessed. The ACTH secretion, in response to stress and/or bilateral lesions of the ACE, was correlated with the serotoninergic activity in specific hypothalamic and amy...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000124652
更新日期:1986-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000122372
更新日期:1975-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章,评审
doi:10.1159/000334903
更新日期:2012-01-01 00:00:00
abstract::These studies investigated the effect of aging on thyroid hormone regulation of beta-endorphin in rat corpus striatum and hypothalamus. In both brain areas, basal levels of beta-endorphin declined with age. In addition, age modified the response of beta-endorphin to thyroid hormone status. Hypothyroid rats aged 6 mont...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123141
更新日期:1981-02-01 00:00:00