Abstract:
:We have suggested that gamma-aminobutyric acid (GABA) in the hypothalamus plays a tonic inhibitory role in the control of the luteinizing hormone (LH) release in intact male rats. To assess whether feedback from the testis alters the inhibitory GABAergic tone in the medial preoptic area (MPO) of male rats, an in vivo microdialysis study was performed in gonadally intact (n = 10), castrated (n = 12) and castrated testosterone-primed (n = 10) male rats. The microdialysis samples were collected and sequential blood samples were also obtained at 1-hour intervals. GABA in the dialysate was determined by high-performance liquid chromatography system and serum LH concentration was determined by radioimmunoassay. Episodic GABA release in the MPO was observed in all three groups of male rats, although castrated male rats showed lower GABA release (2.3 +/- 0.3 ng/h) than intact and castrated testosterone-primed male rats (4.0 +/- 0.5 and 4.6 +/- 1.0 ng/h, respectively). Conversely, castrated male rats showed higher serum LH concentration (7.31 +/- 0.46 ng/ml) than intact and castrated testosterone-primed male rats (0.71 +/- 0.04 and 0.53 +/- 0.07 ng/ml, respectively). In addition, intravenous infusion of bicuculline significantly increased serum LH in intact male rats, whereas bicuculline did not alter serum LH concentrations in castrated male rats. These results are consistent with the hypothesis that the feedback of testosterone stimulates GABA release in the region of the GnRH cell bodies and dendrites in male rats.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
Tin-Tin-Win-Shwe,Mitsushima D,Kimura Fdoi
10.1159/000066625subject
Has Abstractpub_date
2002-11-01 00:00:00pages
290-6issue
5eissn
0028-3835issn
1423-0194pii
66625journal_volume
76pub_type
杂志文章abstract::The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...
journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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journal_title:Neuroendocrinology
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doi:10.1159/000125694
更新日期:1991-01-01 00:00:00
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更新日期:1983-10-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126539
更新日期:1993-08-01 00:00:00
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更新日期:1997-10-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:2006-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123294
更新日期:1982-03-01 00:00:00
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更新日期:1996-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1975-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000076631
更新日期:2004-02-01 00:00:00
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journal_title:Neuroendocrinology
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更新日期:1981-06-01 00:00:00
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更新日期:1994-02-01 00:00:00
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更新日期:1993-05-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123067
更新日期:1980-08-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1159/000126869
更新日期:1995-04-01 00:00:00
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更新日期:1980-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000123292
更新日期:1982-02-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000054351
更新日期:1998-07-01 00:00:00
abstract::The aim of this study was to verify whether prolonged exposure of cultured rat anterior pituitary cells to high glucose can alter growth hormone (GH) release and responsiveness to secretagogues. Therefore, we cultured anterior pituitary cells obtained from normal male Sprague-Dawley rats in presence of normal (6 mM) o...
journal_title:Neuroendocrinology
pub_type: 杂志文章
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journal_title:Neuroendocrinology
pub_type: 杂志文章
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更新日期:1984-04-01 00:00:00
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journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000125536
更新日期:1990-07-01 00:00:00
abstract::Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...
journal_title:Neuroendocrinology
pub_type: 杂志文章
doi:10.1159/000126098
更新日期:1992-01-01 00:00:00