Profiles of in vivo gamma-aminobutyric acid release in the medial preoptic area of intact and castrated male rats.

Abstract:

:We have suggested that gamma-aminobutyric acid (GABA) in the hypothalamus plays a tonic inhibitory role in the control of the luteinizing hormone (LH) release in intact male rats. To assess whether feedback from the testis alters the inhibitory GABAergic tone in the medial preoptic area (MPO) of male rats, an in vivo microdialysis study was performed in gonadally intact (n = 10), castrated (n = 12) and castrated testosterone-primed (n = 10) male rats. The microdialysis samples were collected and sequential blood samples were also obtained at 1-hour intervals. GABA in the dialysate was determined by high-performance liquid chromatography system and serum LH concentration was determined by radioimmunoassay. Episodic GABA release in the MPO was observed in all three groups of male rats, although castrated male rats showed lower GABA release (2.3 +/- 0.3 ng/h) than intact and castrated testosterone-primed male rats (4.0 +/- 0.5 and 4.6 +/- 1.0 ng/h, respectively). Conversely, castrated male rats showed higher serum LH concentration (7.31 +/- 0.46 ng/ml) than intact and castrated testosterone-primed male rats (0.71 +/- 0.04 and 0.53 +/- 0.07 ng/ml, respectively). In addition, intravenous infusion of bicuculline significantly increased serum LH in intact male rats, whereas bicuculline did not alter serum LH concentrations in castrated male rats. These results are consistent with the hypothesis that the feedback of testosterone stimulates GABA release in the region of the GnRH cell bodies and dendrites in male rats.

journal_name

Neuroendocrinology

journal_title

Neuroendocrinology

authors

Tin-Tin-Win-Shwe,Mitsushima D,Kimura F

doi

10.1159/000066625

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

290-6

issue

5

eissn

0028-3835

issn

1423-0194

pii

66625

journal_volume

76

pub_type

杂志文章
  • Repetitive injections of L-glutamic acid, in contrast to those of N-methyl-D,L-aspartic acid, fail to elicit sustained hypothalamic GnRH release in the prepubertal male rhesus monkey (Macaca mulatta).

    abstract::The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126186

    authors: Medhamurthy R,Gay VL,Plant TM

    更新日期:1992-06-01 00:00:00

  • The endogenous stimulatory rhythm regulating prolactin secretion is present in the lactating rat.

    abstract::Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125694

    authors: Arey BJ,Kanyicska B,Freeman ME

    更新日期:1991-01-01 00:00:00

  • Hormonally active arginine-vasopressin suppresses endotoxin-induced fever in rats: lack of effect of oxytocin and a behaviorally active vasopressin fragment.

    abstract::Vasopressin and oxytocin modulate memory processes which effects are dissociated from the typical peripheral endocrine effects of these neuropeptides. Recently, vasopressin has been implicated in the regulation of body temperature. In view of this, experiments were designed to determine whether the antipyretic effect ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123554

    authors: Kovács GL,De Wied D

    更新日期:1983-10-01 00:00:00

  • Preferential distribution of C-terminal fragments of [hydroxyproline9]LHRH in the rat hippocampus and olfactory bulb.

    abstract::Several molecular forms related to the decapeptide LHRH were characterized and quantified in various brain structures of intact and castrated male and female rats. Distinct moieties were separated by high performance liquid chromatography (HPLC) and radioimmunoassayed against anti-LHRH antibodies of different specific...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126539

    authors: Gautron JP,Pattou E,Leblanc P,L'Héritier A,Kordon C

    更新日期:1993-08-01 00:00:00

  • Acute decrease of blood thyroid hormone by isovolemic exchange transfusion as a stimulus for pulse TSH release and its modifications by CNS Lesions.

    abstract::The level of thyroid hormone in blood has been acutely decreased by about 20--30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. Th...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122711

    authors: Langer P,Földes O,Mess B,Kokesová H,Gschwendtová K

    更新日期:1977-01-01 00:00:00

  • Luteinising hormone secretion from the perifused ovine pars tuberalis and pars distalis: effects of gonadotropin-releasing hormone and melatonin.

    abstract::It is not known where melatonin acts to influence the neuroendocrine axis of seasonally breeding mammals. However, since the pars tuberalis (PT) contains the highest density of melatonin receptors, this adenohypophyseal subdivision is a potential target. Gonadotropes are the only immunocytochemically detectable adenoh...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127247

    authors: Skinner DC,Robinson JE

    更新日期:1997-10-01 00:00:00

  • Medical treatment of acromegaly: comorbidities and their reversibility by somatostatin analogs.

    abstract::Relief of symptoms can be achieved following surgery for growth hormone (GH)-secreting adenomas, as well as after pharmacological therapy with somatostatin analogs. Recently, long-acting somatostatin analog depot formulations, octreotide LAR and lanreotide SR have become available. Somatostatin analogs control GH/insu...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章,评审

    doi:10.1159/000095535

    authors: Tolis G,Angelopoulos NG,Katounda E,Rombopoulos G,Kaltzidou V,Kaltsas D,Protonotariou A,Lytras A

    更新日期:2006-01-01 00:00:00

  • Circadian adrenocortical rhythm in the adrenalectomized rat with or without autotransplanted adrenal gland.

    abstract::Circadian rhythm of blood corticosterone in adrenalectomized rats with (AT rat) or without adrenal autotransplants was investigated. Blood samples were obtained individually at 4-hour intervals for a 24-hour period per week for 5-7 consecutive weeks by the tail tip incision method. Corticosterone responses of the auto...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123294

    authors: Murakami N,Takahashi K

    更新日期:1982-03-01 00:00:00

  • Is reverse triiodothyronine a physiological nonactive competitor for the action of triiodothyronine upon the electrical properties of GH3 cells?

    abstract::The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125873

    authors: du Pont JS

    更新日期:1991-08-01 00:00:00

  • Evidence for the presence of receptors for pituitary adenylate cyclase-activating polypeptide in the neurohypophysis that are positively coupled to cyclic AMP formation and neurohypophyseal hormone secretion.

    abstract::This study examines the neural lobe of the pituitary gland for the presence of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) and their possible involvement in the regulation of neurosecretion. The presence of PACAP receptors of type I was revealed in the neural lobe, as well as in anterior a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127113

    authors: Lutz-Bucher B,Monnier D,Koch B

    更新日期:1996-08-01 00:00:00

  • Effect of L-dopa on plasma TSH levels in primary hypothyroidism.

    abstract::Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations to plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypo...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122350

    authors: Minozzi M,Faggiano M,Lombardi G,Carella C,Criscuolo T,Scapagnini U

    更新日期:1975-01-01 00:00:00

  • Neuropeptide Y gene expression in male sheep: influence of photoperiod and testosterone.

    abstract::The frequency of pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) is high in the breeding season and low in the nonbreeding season. These alterations in the patterns of GnRH and LH release are due to an interaction of daylength and gonadal steroid negative feedback. A vast amount...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000076631

    authors: Dobbins A,Lubbers LS,Jackson GL,Kuehl DE,Hileman SM

    更新日期:2004-02-01 00:00:00

  • Relationship between rhythmic motor activity and plasma luteinizing hormone in ovariectomized sheep.

    abstract::The timing of the episodic secretion of luteinizing hormone (LH) in ovariectomized ewes was investigated with respect to an ultradian rest-activity cycle. Individual sheep were enclosed in a chamber where their physical activity was continuously monitored, and blood samples for LH analysis were collected at 5-min inte...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123187

    authors: Rasmussen DD,Malven PV

    更新日期:1981-06-01 00:00:00

  • Splanchnic neural activity modulates ultradian and circadian rhythms in adrenocortical secretion in awake rats.

    abstract::An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in inta...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126645

    authors: Jasper MS,Engeland WC

    更新日期:1994-02-01 00:00:00

  • Progesterone, but not LHRH or prostaglandin E2, induces sequential inhibition of lordosis to various lordogenic agents.

    abstract::In experiment I we studied the capacity of progesterone (P) and two nonsteroidal agents that activate lordosis, but do not bind to the progestin receptor (PR), i.e. luteinizing hormone-releasing hormone (LHRH) and prostaglandin E2 (PGE2) to induce sequential inhibition (SI) in ovariectomized estradiol-primed rats. The...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126457

    authors: González-Mariscal G,Melo AI,Beyer C

    更新日期:1993-05-01 00:00:00

  • Oxytocin in microdissected hypothalamic nuclei. Significant differences between prepubertal and sexually mature female rats.

    abstract::We measured the concentration of oxytocin and vasopressin in microdissected areas of the hypothalamus and posterior pituitary in weanling and adult female rats. Oxytocin concentration was significantly less in adult rats as compared to weanling rats in the supraoptic nucleus, median eminence, and retrochiasmatic area ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123067

    authors: Jackson R,George JM

    更新日期:1980-08-01 00:00:00

  • Effects of somatostatin on human satiety.

    abstract::Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...

    journal_title:Neuroendocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000126831

    authors: Lieverse RJ,Jansen JB,Masclee AM,Lamers CB

    更新日期:1995-02-01 00:00:00

  • Neuroendocrine correlates of the aging brain in humans.

    abstract::Physiological brain aging is characterized by important biochemical and structural changes and by the unbalance among the different neurotransmitters and neuromodulators. The study of the circadian organization of neuroendocrine functions may be considered a clinically reliable tool to investigate the changes of the C...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126869

    authors: Ferrari E,Magri F,Dori D,Migliorati G,Nescis T,Molla G,Fioravanti M,Solerte SB

    更新日期:1995-04-01 00:00:00

  • Androgen and estrogen receptors coexist within individual neurons in the brain of the Syrian hamster.

    abstract::Many aspects of reproductive neuroendocrine function and sexual behavior are responsive to both androgens and estrogens, suggesting that receptors for these steroid hormones may reside within single cells in brain regions that control reproductive function. We determined the distribution of estrogen receptor-containin...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127039

    authors: Wood RI,Newman SW

    更新日期:1995-11-01 00:00:00

  • Adrenal medullary secretory response to stimulation of the medulla oblongata in the rat.

    abstract::In rats anesthetized with sodium pentobarbital, adrenal venous blood samples were collected and analyzed for epinephrine and norepinephrine by the fluorometric method. Stimulation of the inferior fovea or adjacent areas resulted in a significant increase in epinephrine secretion. Stimulation of some other areas of the...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000122949

    authors: Matsui H

    更新日期:1979-01-01 00:00:00

  • Impact of endocrine manipulations on brain-based rat growth hormone.

    abstract::Our laboratory has previously described the widespread distribution of an immunoreactive and bioactive rat growth hormone (rGH)-like protein in rat brain. It has also been demonstrated that regulation of pituitary rGH secretion is at least partly mediated by a short-loop negative feedback system. In such a system, inc...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124668

    authors: Hojvat S,Emanuele NV,Kirsteins L,Lawrence AM

    更新日期:1986-01-01 00:00:00

  • Developmental patterns of the hypothalamic-pituitary axis in the euthyroid and hypothyroid male rat.

    abstract::The purpose of this study was to determine the effect of rendering newborn male Sprague-Dawley rats hypothyroid with 131I on development of the hypothalamic-pituitary axis. Hormonal responses to thyrotropin-releasing hormone (TRH), haloperidol (H), and luteinizing hormone-releasing hormone (LHRH) were determined at 9,...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123011

    authors: Sowers JR,Resch G,Walker S,Sollars E

    更新日期:1980-05-01 00:00:00

  • The luteinizing hormone but not the cortisol response to arginine vasopressin is prevented by naloxone and a corticotropin-releasing hormone antagonist in the ovariectomized rhesus monkey.

    abstract::In the primate, arginine vasopressin (AVP) is known to activate the hypothalamo-pituitary-adrenal axis and to inhibit LH secretion. In the present study, we investigate the role of the endogenous opioid peptides and corticotropin-releasing hormone (CRH) in these processes. Adult ovariectomized rhesus monkeys bearing a...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000127121

    authors: Xiao E,Xia-Zhang L,Thornell D,Shalts E,Ferin M

    更新日期:1996-09-01 00:00:00

  • Photoperiodic effects in the Djungarian hamster. Rate of testicular regression and extension of pineal melatonin pattern depend on the way of change from long to short photoperiods.

    abstract::In the Djungarian hamster, short photoperiods induce regression of testes and accessory glands. There is evidence that the length of time melatonin levels are elevated is the signal conveying the photoperiodic effects to the neuroendocrine axis. When the temporal course of decompression of the pattern of pineal melato...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000124562

    authors: Hoffmann K,Illnerová H

    更新日期:1986-01-01 00:00:00

  • Diurnal variations in rat posterior pituitary catecholamine levels.

    abstract::Diurnal variations, ranging over a twofold difference in concentrations of dopamine, norepinephrine and epinephrine, occur in the rat posterior pituitary gland during a 24-hour period. Highest catecholamine concentrations were seen during daylight hours and low levels reached a nadir 5 h after the onset of darkness. D...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123292

    authors: Barden N,Chevillard C,Saavedra JM

    更新日期:1982-02-01 00:00:00

  • Plasma melatonin rhythm is maintained in human African trypanosomiasis.

    abstract::In human African trypanosomiasis (sleeping sickness), sleep and wake episodes are sporadically distributed throughout the day and the night. Plasma melatonin, sleep-wakefulness and rectal temperature rhythms were studied in 9 Congolese patients suffering from sleeping sickness compared to 6 healthy controls submitted ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000054351

    authors: Claustrat B,Buguet A,Geoffriau M,Bogui P,Mouanga G,Stanghellini A,Dumas M

    更新日期:1998-07-01 00:00:00

  • Effects of acute and prolonged glucose excess on growth hormone release by cultured rat anterior pituitary cells.

    abstract::The aim of this study was to verify whether prolonged exposure of cultured rat anterior pituitary cells to high glucose can alter growth hormone (GH) release and responsiveness to secretagogues. Therefore, we cultured anterior pituitary cells obtained from normal male Sprague-Dawley rats in presence of normal (6 mM) o...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125947

    authors: Renier G,Serri O

    更新日期:1991-11-01 00:00:00

  • Effect of maternal ethanol ingestion on control of growth hormone secretion by biogenic amines in rat offspring.

    abstract::Pregnant rats were kept on an ethanol-containing (6% w/v) liquid diet from the 13th day of gestation and serum growth hormone (GH) levels were determined in the offspring after four different experimental paradigms. In controls, administration of cyproheptadine (a serotonin-blocking agent), or insulin, or exposure to ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000123910

    authors: Thadani PV

    更新日期:1984-04-01 00:00:00

  • Pyridostigmine potentiates L-dopa- but not arginine- and galanin-induced growth hormone secretion in children.

    abstract::The coadministration of growth hormone (GH) secretagogues can provide insight into the neuroregulation of GH secretion. The GH response to L-dopa (125, 250 and 500 mg orally for body weights less than 15 kg, between 15 and 30 kg and greater than 30 kg, respectively), arginine (Arg; 0.5 g/kg infused intravenously over ...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000125536

    authors: Ghigo E,Bellone J,Imperiale E,Arvat E,Mazza E,Valetto MR,Boffano GM,Cappa M,Loche S,De Sanctis C

    更新日期:1990-07-01 00:00:00

  • Fetal development of delta-sleep-inducing-peptide-like immunoreactivity in hypothalamus of guinea pig with special regard to the prenatal colocalization with gonadotropin-releasing-hormone-like immunoreactivity.

    abstract::Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...

    journal_title:Neuroendocrinology

    pub_type: 杂志文章

    doi:10.1159/000126098

    authors: Pu LP,Dubois PM

    更新日期:1992-01-01 00:00:00