Abstract：
:The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials were suppressed, and changes in the slope conductance were similar to those seen in response to T3. Membrane resistance RI decreased, and the resting membrane potential VM hyperpolarized. The action of rT3 is a 1,000 times less potent than that of T3 and is unlikely to have a physiological significance. When a cell was beforehand superfused with rT3 (10 nM), the effect of T3 was prevented even in a concentration of 10 nM. The specificity of T3, the prevention of the effect of T3 by rT3, and the small dose needed suggest a binding site for T3. The short latency of its action implies an extranuclear binding site, probably in or near the plasma membrane of the GH3 cell.
journal_name
Neuroendocrinologyjournal_title
Neuroendocrinologyauthors
du Pont JSdoi
10.1159/000125873subject
Has Abstractpub_date
1991-08-01 00:00:00pages
146-50issue
2eissn
0028-3835issn
1423-0194journal_volume
54pub_type
杂志文章abstract：:Administration of the bovine pineal peptide threonylseryllysine (TSL) to unilaterally ovariectomized (UO) mice as a single intraperitoneal injection on the day of UO reduced the 5-day compensatory ovarian hypertrophy. The same dose of TSL (175 ng/animal) significantly (p less than 0.01) reduced serum follicle stimulat...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123056
更新日期：1980-08-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF) has been characterized on the basis of its intrinsic activity to release corticotropin from cultured rat anterior pituitary cells. Injected in intact rats, CRF increases adrenocorticotropic hormone (ACTH) release. Endogenous CRF-like immunoreactivity was detected in the cytoplasm a...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125186
更新日期：1989-06-01 00:00:00
abstract：:To assess the neuroendocrine correlates of menstrual status migrainosus (MSM) and menstrual migraine (MM), we evaluated the prolactin (PRL) and cortisol responses to the direct central serotoninergic (5-HT) agonist meta-chlorophenylpiperazine (m-CPP) administered orally (0.5 mg/kg) during the follicular (FP: +6, +8) a...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章
doi：10.1159/000071706
更新日期：2003-07-01 00:00:00
abstract：:Autoradiographic methods were used to study the location of estrogen-concentrating cells in the brain of the female hamster. In the hypothalamus, well-labelled cells were reliably found in the posterior medial preoptic area (MPOA), the anterior hypothalamus (AHA), and the ventromedial (VM), arcuate (ARC) and ventral p...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122626
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND/AIMS:Tryptophan is the precursor of serotonin and niacin (vitamin B3). The latter is critical for normal cellular metabolism. Tryptophan and niacin can be deficient in patients with serotonin-producing neuroendocrine tumors (NETs). Niacin deficiency may lead to severe symptoms including pellagra. In patients...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000440621
更新日期：2016-01-01 00:00:00
abstract：:The anterior pituitary is permanently regulated by processes of apoptosis and proliferation in order to maintain tissue homeostasis. Several factors have been implicated in this regulation and lately, prolactin (PRL) has been included into that list. However, since PRL is secreted by anterior pituitary lactotropes, th...
journal_title：Neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1159/000354701
更新日期：2013-01-01 00:00:00
abstract：:We have attempted to elucidate the effect of glucose concentrations on the release of thyrotropin-releasing hormone (TRH), a brain neuropeptide possessing glucoregulatory function, from rat hypothalamic slices in vitro. Rat hypothalamic slices were preincubated for 60 min at 37 degrees C in Krebs-Ringer bicarbonate (K...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125751
更新日期：1991-04-01 00:00:00
abstract：:Oxytocin (OT) binding sites are modulated by estrogens in several brain regions including the ventromedial hypothalamic nucleus (VMN) in both male and female rats. To further study steroid regulation of OT receptor binding, we examined the effect of androgen replacement in castrated male rats on OT binding with quanti...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125222
更新日期：1989-08-01 00:00:00
abstract：:The hypophysial portal vessels and anterior pituitary glands of adult male rats were surgically exposed, cannulated and infused for 1 min with saline, growth hormone-releasing factor (GH-RF), and dbcAMP. After cessation of infusion, anterior pituitary glands were collected at 1, 5, 15, 30 or 60 min for electron micros...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122421
更新日期：1975-01-01 00:00:00
abstract：:[125I]-neuropeptide Y receptors were characterized in the rat pituitary gland using quantitative autoradiography. Scatchard analysis of saturation isotherms showed high affinity (Kd 8.5 x 10(-11) M) and single class of binding sites (Bmax 0.22 pmol/mg of protein) in the posterior lobe of the pituitary gland, with no s...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125608
更新日期：1990-10-01 00:00:00
abstract：:Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (greater than or equal to 50 ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123499
更新日期：1983-06-01 00:00:00
abstract：:Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of ex...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125182
更新日期：1989-06-01 00:00:00
abstract：:Hypophyseal and ovarian receptors for the neurohormone LHRH (LHRH-R) have been measured in young (3-4 months), middle-aged (8-11 months), constant estrous (CE, 10-14 months) and pseudopregnant (PR, 16-18 months) rats in order to study whether changes in hypothalamic and/or peripheral LHRH-like peptide production might...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125018
更新日期：1988-09-01 00:00:00
abstract：:Prolactin (PRL) secretion in the female rat is regulated by an endogenous stimulatory rhythm (ESR), which is normally under the tonic inhibition of dopamine (DA). The ESR consists of a nocturnal (N) component which peaks at approximately 03.00 h, and a diurnal (D) component which peaks at approximately 17.00 h. This E...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125694
更新日期：1991-01-01 00:00:00
abstract：:Met-enkephalin concentrations in the anterior pituitary gland were shown to decline dramatically within the first 24 h after reserpine treatment, with effects apparent as early as 6 h. This was followed by subsequent repletion and late augmentation of Met-enkephalin levels 3 weeks following reserpine. Treatment with t...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124905
更新日期：1988-02-01 00:00:00
abstract：:The effect of catecholamines on plasma levels of immunoreactive ACTH (ACTHi), alpha-MSH (alpha-MSHi), beta-endorphin (beta-ENDi), arginine-vasopressin (AVPi) and of corticosterone (B) was studied in female rats. Intravenous infusion of the specific beta-adrenoceptor-stimulating agent l-isoproterenol in Wistar rats und...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123529
更新日期：1983-08-01 00:00:00
abstract：:There is extensive evidence that serotonin (5-HT) is implicated in the neuroendocrine control regulating the secretion of several anterior pituitary hormones. It has also been reported that the posterior pituitary is necessary for prolactin (PRL) response to 5-HT as well as to suckling, in which 5-HT implication has b...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000054381
更新日期：1998-11-01 00:00:00
abstract：:Circadian rhythms occur in hypothalamic serotonin content in the turkey. Inhibition of serotonin (5-HT) synthesis by parachlorophenylalanine (PCPA) blocks circadian variation in hypothalamic serotonin levels suggesting that the major cause of diurnal fluctuations is differing rates of synthesis of the amine. PCPA trea...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000123299
更新日期：1982-03-01 00:00:00
abstract：:Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126225
更新日期：1992-08-01 00:00:00
abstract：:Somatostatin (ST) inhibits gastrointestinal motility and exocrine and endocrine secretions. In animals, ST has been demonstrated to decrease food intake. We investigated, in a randomized double-blind investigation in 10 healthy humans, the effects of an intravenous ST infusion compared to saline on subjective hunger f...
journal_title：Neuroendocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000126831
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Cortisol is thought to be involved in the pathophysiology of affective disorders. Less attention has been given to other neuroendocrine factors. The aim of the present study was to test the hypothesis that adrenocortical steroids aldosterone and cortisol show different dynamic changes in the course...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000505921
更新日期：2020-01-01 00:00:00
abstract：:Leptin, the product of the obese gene, is a protein that is secreted primarily from adipocytes. Leptin can influence the function of the pituitary gland through its action on the hypothalamus, but it can also directly act at the level of the pituitary gland. The ability of leptin to induce an increase in intracellular...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000081843
更新日期：2004-01-01 00:00:00
abstract：:In experiment I we studied the capacity of progesterone (P) and two nonsteroidal agents that activate lordosis, but do not bind to the progestin receptor (PR), i.e. luteinizing hormone-releasing hormone (LHRH) and prostaglandin E2 (PGE2) to induce sequential inhibition (SI) in ovariectomized estradiol-primed rats. The...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126457
更新日期：1993-05-01 00:00:00
abstract：:In the present paper the effects of estradiol and testosterone on the expression of the types 1 and 5 somatostatin receptors (sst1 and sst5) in the goldfish forebrain and pituitary were investigated. Estradiol increased the sst1 expression in both the forebrain and pituitary in a dose- and time-dependent manner. In ad...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000071963
更新日期：2003-08-01 00:00:00
abstract：:The possible role of prostaglandins (PGs) in the hypothalamic control of ovulation has been investigated by studying the effects of indomethacin (ID) and PGs on the release of luteinizing hormone-releasing hormone (LHRH) from hypothalamic synaptosomes. Female rats were chronically pretreated with ID on diestrus 2 (D2)...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000122888
更新日期：1979-01-01 00:00:00
abstract：:The present studies were undertaken to investigate the effect of gender on thyrotropin-releasing hormone (TRH) gene expression in cultured anterior pituitary (AP) cells. AP cells derived from 15-day-old male, female, or female pups that had been neonatally treated with testosterone propionate (TP), were cultured for u...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126815
更新日期：1995-01-01 00:00:00
abstract：:Specific lesions of different brain structures known to contain or to be coursed by LHRH neurons have been carried out in intact cycling female rats in order to investigate the role played by central LHRH and neuronal systems in the regulation of ovarian and hypophyseal LHRH receptor (LHRH-R) levels, using the stable ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000124196
更新日期：1985-10-01 00:00:00
abstract：:Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000126424
更新日期：1993-04-01 00:00:00
abstract：:Neurons in the adult rat ventromedial hypothalamic nucleus (VMN, 4-6 neurons per brain; 3-7 brains per group) were studied under various hormonal conditions using the single-section Golgi impregnation technique. Intact rats of both sexes and ovariectomized females treated with oil, estrogen or estrogen and progesteron...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000125387
更新日期：1990-05-01 00:00:00
abstract：:We have suggested that gamma-aminobutyric acid (GABA) in the hypothalamus plays a tonic inhibitory role in the control of the luteinizing hormone (LH) release in intact male rats. To assess whether feedback from the testis alters the inhibitory GABAergic tone in the medial preoptic area (MPO) of male rats, an in vivo ...
journal_title：Neuroendocrinology
pub_type： 杂志文章
doi：10.1159/000066625
更新日期：2002-11-01 00:00:00
